Mon panier

Human Serpin G1 / C1 inhibitor Protein, His Tag, low endotoxin (active enzyme, MALS verified)

Avis des utilisateurs
Numéro de produit/spécification
Prix
Qté
SER-H52H5-200ug
$290.00
SER-H52H5-1mg (500ug X 2)
$1080.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    SERPING1, C1IN, C1-INH, C1IN, HAE1, HAE2

  • Source

    Human Serpin G1 Protein, His Tag (SER-H52H5) is expressed from human 293 cells (HEK293). It contains AA Asn 23 - Ala 500 (Accession # P05155-1).

    Predicted N-terminus: Asn 23

    Request for sequence
  • Molecular Characterization

    Serpin G1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 54.7 kDa. The protein migrates as 75-105 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

Les clients ont également consulté

Affichage des données

  • SDS-PAGE

    Serpin G1 SDS-PAGE

    Human Serpin G1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Serpin G1 SEC-MALS

    The purity of Human Serpin G1 Protein, His Tag (Cat. No. SER-H52H5) is more than 95% and the molecular weight of this protein is around 65-85 kDa verified by SEC-MALS.

    Report
  • Bioactivity

     Serpin G1 ENZYME

    Measured by its ability to inhibit Recombinant Human Complement Component C1s cleavage of a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-K-SBzl). The IC50 is <4 nM (QC tested).

    Protocol

Avis des utilisateurs
Publier un commentaire

Introduction de fond

Serpin G1/C1-inhibitor (C1-INH) is an important regulator of the complement, coagulation, fibrinolytic and contact systems. The quantity of protease/C1-INH complexes in the blood is proportional to the level of the in vivo activation of these four cascade-like plasma enzyme systems. It inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE).

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Plasma protease C1 inhibitor

  • Catégorie:

  • Nombre de médicaments répertoriés:

    0 Détails

  • Nombre de médicaments cliniques:

    1 Détails

  • Étape de développement la plus élevée:

    Phase 2 Clinical

Drug Candidate Licensing
More
  • Informations de base sur le produit
  • Détails du produit
  • Les clients ont également consulté
  • Affichage des données
  • Avis des utilisateurs
  • Contexte