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Human Tau-441 / 2N4R (P301S) Protein, His Tag, low endotoxin (MALS verified)

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Numéro de produit/spécification
Prix
Qté
TAU-H5145-100ug
$360.00
TAU-H5145-1mg
$2380.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

  • Source

    Human Tau-441 (P301S), His Tag (TAU-H5145) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8 (P301S)).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    Tau Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 47.7 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Tau SDS-PAGE

    Human Tau-441 (P301S), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    Tau SEC-MALS

    The purity of Human Tau-441 (P301S), His Tag (Cat. No. TAU-H5145) is more than 85% and the molecular weight of this protein is around 45-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Tau ELISA

    Immobilized Human Tau-441 (P301S), His Tag (Cat. No. TAU-H5145) at 1 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.4-13 ng/mL (QC tested).

    Protocol

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Introduction de fond

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Microtubule-associated protein tau

  • Catégorie:

  • Nombre de médicaments répertoriés:

    1 Détails

  • Nombre de médicaments cliniques:

    46 Détails

  • Étape de développement la plus élevée:

    Approved

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