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Détails du produit
Synonyms
MPL, C-MPL, CD110, MPLV, THCYT2, TPOR
Source
Mouse Thrombopoietin R Protein, His Tag (THR-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Trp 482 (Accession # Q08351-1).
Predicted N-terminus: Gln 26
Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 53.1 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Affichage des données
SDS-PAGE
Mouse Thrombopoietin R Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Mouse Thrombopoietin R Protein, His Tag (Cat. No. THR-M52H3) is more than 95% and the molecular weight of this protein is around 50-70 kDa verified by SEC-MALS.
Report
Bioactivity-SPR
Mouse Thrombopoietin R Protein, His Tag (Cat. No. THR-M52H3) capture on NTA-Series S sensor chip can bind Human Thrombopoietin Protein, Tag Free with an affinity constant of 5.67 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
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Introduction de fond
Progrès de frontière
Progrès du développement médicamenteux- Nom anglais：
Thrombopoietin receptor
- Catégorie：
- Nombre de médicaments répertoriés：
8 Détails
- Nombre de médicaments cliniques：
11 Détails
- Étape de développement la plus élevée：
Approved
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