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Cynomolgus Complement C1s Protein, His Tag (MALS verified)

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Numéro de produit/spécification
Prix
Qté
COS-C52H3-100ug
$395.00
COS-C52H3-1mg (500ug X 2)
$2500.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    EDSPD2

  • Source

    Cynomolgus Complement C1s Protein, His Tag (COS-C52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 16 - Asp 688 (Accession # A0A2K5VQX9).

    Predicted N-terminus: Glu 16

    Request for sequence
  • Molecular Characterization

    Complement C1s Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 76.7 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Complement C1s SDS-PAGE

    Cynomolgus Complement C1s Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Complement C1s SEC-MALS

    The purity of Cynomolgus Complement C1s Protein, His Tag (Cat. No. COS-C52H3) is more than 90% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Complement C1s ELISA

    Immobilized Claseprubart at 5 μg/mL (100 μL/well) can bind Cynomolgus Complement C1s Protein, His Tag (Cat. No. COS-C52H3) with a linear range of 0.01-0.156 μg/mL (QC tested).

    Protocol

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Introduction de fond

Complement C1s is a serine protease and a key component of the C1 complex in the classical complement pathway. One C1q molecule binds to a tetramer composed of two C1r and two C1s proteases to form the intact C1 complex. C1s circulates as a zymogen until activated by proteolytic cleavage from activated C1r. Its essential function is to cleave complement components C4 and C2, thereby initiating the formation of the C3 convertase (C4b2a). This step is critical for triggering downstream immune effector functions, including opsonization, inflammation, and membrane attack complex formation.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    Complement C1s

  • Catégorie:

  • Nombre de médicaments répertoriés:

    4 Détails

  • Nombre de médicaments cliniques:

    5 Détails

  • Étape de développement la plus élevée:

    Approved

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