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Mouse Fc epsilon RI alpha Protein, Fc Tag

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Numéro de produit/spécification
Prix
Qté
FCA-M5253-100ug
$300.00
FCA-M5253-1mg (500ug X 2)
$1980.00
ETA of in-stock products:2 business days
Total des articles Montant du produit$ 0

Détails du produit

  • Synonyms

    FCER1A, FCE1A, FcERI

  • Source

    Mouse Fc epsilon RI alpha Protein, Fc Tag (FCA-M5253) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Gln 204 (Accession # P20489).

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  • Molecular Characterization

    Fc epsilon RI alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 47.6 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 225 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Fc epsilon RI alpha SDS-PAGE

    Mouse Fc epsilon RI alpha Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Fc epsilon RI alpha ELISA

    Immobilized Mouse IgE Fc Protein, His Tag (Cat. No. IGE-M52H3) at 10 μg/mL (100 μL/well) can bind Mouse Fc epsilon RI alpha Protein, Fc Tag (Cat. No. FCA-M5253) with a linear range of 0.039-5 μg/mL (QC tested).

    Protocol

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Introduction de fond

Fc epsilon RI alpha (FcεRIα) is the α-chain of the high-affinity IgE receptor (FcεRI), a critical mediator of type I hypersensitivity. As a transmembrane glycoprotein in the immunoglobulin superfamily, its extracellular domain specifically binds the Fc region of IgE. Mainly expressed on mast cells and basophils, FcεRIα cross-linking (by IgE-allergen complexes) triggers cell degranulation, releasing histamine and proinflammatory mediators—driving allergies, asthma, and anaphylaxis. It also participates in immune surveillance. Owing to its central role in allergic responses, FcεRIα is a key therapeutic target for anti-allergy agents.

Progrès de frontière

 
Progrès du développement médicamenteux
  • Nom anglais:

    IgE Fc receptor, alpha-subunit

  • Catégorie:

  • Nombre de médicaments répertoriés:

    1 Détails

  • Nombre de médicaments cliniques:

    1 Détails

  • Étape de développement la plus élevée:

    Approved

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