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Human CD39 / ENTPD1 Protein, His Tag (active enzyme, MALS verified)

COADS MS
DS

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Cat. No. / Size
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CD9-H52H4-100ug
$435.00
CD9-H52H4-1mg (200ug X 5)
$3095.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    CD39, ENTPD1, NTPDase 1, Entpd1, Ecto-ATPDase 1, Ecto-ATPase 1

  • Source

    Human CD39, His Tag (CD9-H52H4) is expressed from human 293 cells (HEK293). It contains AA Thr 38 - Val 478 (Accession # P49961-1).

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  • Molecular Characterization

    CD39 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 52.3 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris and NaCl, pH8.0 with trehalose as protectant.

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD39 SDS-PAGE

    Human CD39, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CD39 SEC-MALS

    The purity of Human CD39, His Tag (Cat. No. CD9-H52H4) is more than 95% and the molecular weight of this protein is around 60-80 kDa verified by SEC-MALS.

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  • Bioactivity-ELISA

    CD39 ELISA

    Immobilized Human CD39, His Tag (Cat. No. CD9-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (QC tested).

    Protocol

  • Bioactivity

    Measured by its ability to hydrolyze the 5’-phosphate group from the substrate adenosine-5’-triphosphate (ATP). The specific activity is > 6,000 pmol/min/μg (QC tested).

    Protocol

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Background

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

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Drug Development Progress
  • English Name：

    Ectonucleoside triphosphate diphosphohydrolase 1

  • Category：

  • Approved Drugs：

    0 Details

  • Drugs in Clinical Trials：

    10 Details

  • Highest Development Stage：

    Phase 2 Clinical

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