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Your Position: Accueil > Protein > PVRIG > PVG-M5257

Mouse PVRIG Protein, Fc Tag (MALS verified)

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  • Synonym
    C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor
  • Source
    Mouse PVRIG, Fc Tag(PVG-M5257) is expressed from human 293 cells (HEK293). It contains AA Ser 35 - Asp 165 (Accession # A0A1B0GS01-1).
    Predicted N-terminus: Ser 35
  • Molecular Characterization
    PVRIG Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.6 kDa. The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
PVRIG SDS-PAGE

Mouse PVRIG, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
PVRIG MALS images

The purity of Mouse PVRIG, Fc Tag (Cat. No. PVG-M5257) is more than 90% and the molecular weight of this protein is around 85-110 kDa verified by SEC-MALS.

  • Background
    Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
  • Clinical and Translational Updates

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Price(EUR) : €380.00

Price(EUR) : €2670.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:7 Details
  • Latest Research Phase:Phase 2 Clinical

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