Anlotinib Dihydrochloride |
AL-3818 |
Approved |
Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd |
福可维 |
Mainland China |
Carcinoma, Non-Small-Cell Lung |
Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd |
2018-05-08 |
Sarcoma, Alveolar Soft Part; Bile Duct Diseases; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Hepatic Insufficiency; Bone Neoplasms; Urologic Neoplasms; Fallopian Tube Neoplasms; Thyroid Neoplasms; Endometrial Neoplasms; Medullary thyroid cancer (MTC); Gallbladder Neoplasms; Glioma; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Osteoma; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Leiomyosarcoma; Solid tumours; Drug-Related Side Effects and Adverse Reactions; Biliary Tract Neoplasms; Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Thoracic Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Lung Diseases, Interstitial; Liver Diseases; Sarcoma; Nasopharyngeal Carcinoma |
Details
|
Imatinib mesylate |
CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201 |
Approved |
Novartis Pharma Ag |
glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec |
EU |
Leukemia, Myelogenous, Chronic |
Novartis Europharm Ltd |
2001-05-10 |
Leukemia, Myelogenous, Chronic; Hypereosinophilic Syndrome; Ovarian Neoplasms; Leukemia; Ovarian germ cell tumor; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Hematopoietic stem cell transplantation (HSCT); Fibrosarcoma; Head and Neck Neoplasms; Hypertension, Pulmonary; Neoplasm, Residual; Genital Diseases, Male; Diabetes Mellitus, Type 1; Loiasis; Lymphoma, B-Cell, Marginal Zone; Abdominal Neoplasms; Leukemia, Hairy Cell; Desmoplastic Small Round Cell Tumor; Polycythemia Vera; Rhinitis, Allergic, Seasonal; Histiocytoma, Malignant Fibrous; Genital Neoplasms, Male; Macular Edema; Rectal Neoplasms; Stomach Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Colonic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; Mastocytosis, Systemic; Myelodysplastic Syndromes; Dermatofibrosarcoma; Scleroderma, Systemic; Plasmacytoma; Skin Neoplasms; Leukem |
Details
|
Lenvatinib Mesylate |
MK-7902; ER-203492-00; E-7080 |
Approved |
Eisai Co Ltd |
Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 |
United States |
Thyroid Neoplasms |
Eisai Inc |
2015-02-13 |
Carcinoma, Adenoid Cystic; Paraganglioma; Melanoma; Thyroid Cancer, Papillary; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Glioma; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Breast Neoplasms; Cholangiocarcinoma; Osteosarcoma; Solid tumours; Neuroendocrine Tumors; Adenocarcinoma, Follicular; Liver Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Kidney Diseases; Neoplasms; Pheochromocytoma; Esophageal Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms |
Details
|
Regorafenib |
DAST; BAY-73-4506 |
Approved |
Bayer AG |
Stivarga, Resihance |
United States |
Colorectal Neoplasms |
Bayer Healthcare Pharmaceuticals Inc |
2012-09-27 |
Fallopian Tube Neoplasms; Osteosarcoma; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Bone Neoplasms; Bile Duct Neoplasms; Thymoma; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Gastrinoma; Lung Neoplasms; Esophageal adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Gastrointestinal Neoplasms; Somatostatinoma; Adenocarcinoma; Neoplasm Metastasis; Meningioma; Neoplasms; Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Carcinoid Tumor; Insulinoma; Carcinoma, Islet Cell; Stomach Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Pancreatic Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Sarcoma |
Details
|
Avapritinib |
BLU-285; CS-3007 |
Approved |
Blueprint Medicines Corp |
Ayvakyt, Ayvakit, 泰吉华 |
United States |
Gastrointestinal Stromal Tumors |
Blueprint Medicines Corp |
2020-01-09 |
Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma |
Details
|
Vorolanib |
X-82; EYP-1901; CM-082 |
Approved |
Tyrogenex Inc |
伏美纳 |
Mainland China |
Carcinoma, Renal Cell |
Betta Pharmaceuticals Co Ltd |
2023-06-07 |
Diabetic macular oedema; Carcinoma, Non-Small-Cell Lung; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Diabetic Retinopathy; Choroidal Neovascularization; Adenocarcinoma; Retinal Degeneration; Leukemia, Myeloid, Acute; Eye Diseases; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms |
Details
|
Ripretinib |
DCC-2618 |
Approved |
Deciphera |
Qinlock, 擎乐 |
United States |
Gastrointestinal Stromal Tumors |
Deciphera Pharmaceuticals Llc |
2020-05-15 |
Neoplasms; Mastocytosis, Systemic; Gastrointestinal Stromal Tumors |
Details
|
Olverembatinib |
GZD-824; APG-1351; GIBH-824; HQP-1351; D-824 |
Approved |
Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences |
耐立克 |
Mainland China |
Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase |
Guangzhou Shunjian Biomedical Technology Co Ltd |
2021-11-25 |
Solid tumours; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors |
Details
|
Ponatinib Hydrochloride |
AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 |
Approved |
Ariad |
Iclusig |
United States |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic |
Ariad Pharmaceuticals Inc |
2012-12-14 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms |
Details
|
Sunitinib Malate |
PNU-290940AD; PHA-290940AD; SCAI-003; GB-102; PNU-290940; SU-011248-L-malate salt; PHA-290940; SU-010398; SU-11248 |
Approved |
Pfizer Inc |
索坦, Sutent |
United States |
Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors |
Cppi Cv |
2006-01-26 |
Solid tumours; Fibromatosis, Aggressive; Ovarian Neoplasms; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Leukemia, Myeloid, Accelerated Phase; Leukemia; Fibrosarcoma; Teratoma; Liver Neoplasms; Ependymoma; Lymphoma, T-Cell, Peripheral; Intestinal Neoplasms; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Hemangioblastoma; Carcinoma, Islet Cell; Carcinoma; Pheochromocytoma; Stomach Neoplasms; Pelvic Neoplasms; Esophageal Neoplasms; Leukemia, Hairy Cell; Polycythemia Vera; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatoses; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Carcinoma, Papil |
Details
|
Dasatinib Hydrate |
NSC-732517; BMS-354825; XS-004 |
Approved |
Bristol-Myers Squibb Company |
施达赛, Dasynoc, Spricel, Sprycel, Spraysel |
United States |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic |
Bristol-Myers Squibb Company |
2006-06-28 |
Primary Myelofibrosis; Hemangiopericytoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia; Laryngeal Neoplasms; Lymphoma; Gliosarcoma; Peritoneal Neoplasms; Astrocytoma; Giant Cell Tumor of Bone; Gastrointestinal Stromal Tumors; Sarcoma, Alveolar Soft Part; Leukemia, Myeloid, Chronic-Phase; Sarcoma, Ewing; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Sarcoma; Neurofibrosarcoma; Breast Neoplasms; Brain Neoplasms; Melanoma; Leukemia, T-Cell; Carcinoma, Hepatocellular; Leukemia, Large Granular Lymphocytic; Adenocarcinoma; Mycosis Fungoides; Heart Arrest; Mastocytosis; Tongue Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Leukemia, Lymphocytic, Chronic, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Fallopian Tube Neoplasms; Lymphoma, T-Cell, Cutaneous; Uterine Neoplasms; Burkitt Lymphoma; Neoplasms, Gonadal Tissue; Intraocular Lymphoma; Lymphoma, Large-Cell, Anaplas |
Details
|
Pexidartinib |
PLX-3397 |
Approved |
Daiichi Sankyo Co Ltd |
Turalio |
United States |
Giant Cell Tumor of Tendon Sheath |
Daiichi Sankyo Inc |
2019-08-02 |
Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neurofibrosarcoma; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath |
Details
|
Pazopanib Hydrochloride |
GSK-786034; GW-786034B; SB-786034; GW-786034 |
Approved |
Glaxosmithkline Plc, Novartis Pharma Ag |
维全特, Armala, Votrient, Patorma |
United States |
Carcinoma, Renal Cell; Sarcoma |
Novartis Pharma Ag |
2009-10-19 |
Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a |
Details
|
Cabozantinib S-malate |
XL-184; BMS-907351 |
Approved |
Exelixis Inc |
Cometriq, Cabometyx |
United States |
Carcinoma, Neuroendocrine; Thyroid Neoplasms |
Exelixis Inc |
2012-11-29 |
Urethral Neoplasms; Leukemia, Myeloid, Acute; Thyroid Neoplasms; Gliosarcoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Peritoneal Neoplasms; Bile Duct Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Adenocarcinoma, Clear Cell; Sarcoma, Ewing; Carcinoma, Adenosquamous; Breast Neoplasms; Neurofibroma, Plexiform; Osteosarcoma; Prostatic Neoplasms; Sarcoma; Medullary thyroid cancer (MTC); Carcinoma, Hepatocellular; Melanoma; Paraganglioma; Meningioma; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Brain Neoplasms; Carcinoma, Neuroendocrine; Sarcoma, Alveolar Soft Part; Lymphoma; Fallopian Tube Neoplasms; Brain metastases; Glioma; Endometrial Neoplasms; Carcinoma, Squamous Cell; Carcinoid Tumor; Glioblastoma; Skin Neoplasms; Neoplasms; Carcinoma, Papillary; Hepatoblastoma; Pheochromocytoma; Pain; Rejection of liver transplantation; Carcinoma, Renal Cell; Pancreatic neuroendocrine tumors |
Details
|
Sorafenib Tosylate |
NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 |
Approved |
Onyx Pharmaceuticals Inc |
Nexavar, 多吉美 |
United States |
Carcinoma, Renal Cell |
Bayer Healthcare Pharmaceuticals Inc |
2005-12-01 |
Liver Neoplasms; Kidney Neoplasms; Recurrence; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Rhabdomyosarcoma; Lymphoma, B-Cell, Marginal Zone; Fibromatosis, Aggressive; Head and Neck Neoplasms; Solid tumours; Leiomyosarcoma; Leukemia, Myeloid; Carcinoma, Renal Cell; Carcinoma; Vipoma; Esophageal Neoplasms; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Carcinoid Tumor; Histiocytoma, Malignant Fibrous; Carcinoma, Islet Cell; Insulinoma; Stomach Neoplasms; Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Thyroid Carcinoma, Anaplastic; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Wilms Tumor; Lymphomatoid Granulomatosis; Colonic Neoplasms; Hypertension, Portal; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Multiple Endo |
Details
|
Midostaurin |
PKC-412; PKC-412A; CGP-41231; CGP-41251 |
Approved |
Novartis Pharma Ag |
Rydapt |
United States |
Mastocytosis, Systemic; Leukemia, Mast-Cell; Hematologic Neoplasms; Leukemia, Myeloid, Acute |
Novartis Pharmaceuticals Corp |
2017-04-28 |
Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis |
Details
|
Anlotinib Dihydrochloride |
AL-3818 |
Approved |
Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd |
福可维 |
Mainland China |
Carcinoma, Non-Small-Cell Lung |
Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd |
2018-05-08 |
Sarcoma, Alveolar Soft Part; Bile Duct Diseases; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Hepatic Insufficiency; Bone Neoplasms; Urologic Neoplasms; Fallopian Tube Neoplasms; Thyroid Neoplasms; Endometrial Neoplasms; Medullary thyroid cancer (MTC); Gallbladder Neoplasms; Glioma; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Osteoma; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Leiomyosarcoma; Solid tumours; Drug-Related Side Effects and Adverse Reactions; Biliary Tract Neoplasms; Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Thoracic Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Lung Diseases, Interstitial; Liver Diseases; Sarcoma; Nasopharyngeal Carcinoma |
Details
|
Imatinib mesylate |
CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201 |
Approved |
Novartis Pharma Ag |
glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec |
EU |
Leukemia, Myelogenous, Chronic |
Novartis Europharm Ltd |
2001-05-10 |
Leukemia, Myelogenous, Chronic; Hypereosinophilic Syndrome; Ovarian Neoplasms; Leukemia; Ovarian germ cell tumor; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Hematopoietic stem cell transplantation (HSCT); Fibrosarcoma; Head and Neck Neoplasms; Hypertension, Pulmonary; Neoplasm, Residual; Genital Diseases, Male; Diabetes Mellitus, Type 1; Loiasis; Lymphoma, B-Cell, Marginal Zone; Abdominal Neoplasms; Leukemia, Hairy Cell; Desmoplastic Small Round Cell Tumor; Polycythemia Vera; Rhinitis, Allergic, Seasonal; Histiocytoma, Malignant Fibrous; Genital Neoplasms, Male; Macular Edema; Rectal Neoplasms; Stomach Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Colonic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; Mastocytosis, Systemic; Myelodysplastic Syndromes; Dermatofibrosarcoma; Scleroderma, Systemic; Plasmacytoma; Skin Neoplasms; Leukem |
Details
|
Lenvatinib Mesylate |
MK-7902; ER-203492-00; E-7080 |
Approved |
Eisai Co Ltd |
Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 |
United States |
Thyroid Neoplasms |
Eisai Inc |
2015-02-13 |
Carcinoma, Adenoid Cystic; Paraganglioma; Melanoma; Thyroid Cancer, Papillary; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Glioma; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Breast Neoplasms; Cholangiocarcinoma; Osteosarcoma; Solid tumours; Neuroendocrine Tumors; Adenocarcinoma, Follicular; Liver Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Kidney Diseases; Neoplasms; Pheochromocytoma; Esophageal Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms |
Details
|
Regorafenib |
DAST; BAY-73-4506 |
Approved |
Bayer AG |
Stivarga, Resihance |
United States |
Colorectal Neoplasms |
Bayer Healthcare Pharmaceuticals Inc |
2012-09-27 |
Fallopian Tube Neoplasms; Osteosarcoma; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Bone Neoplasms; Bile Duct Neoplasms; Thymoma; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Gastrinoma; Lung Neoplasms; Esophageal adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Gastrointestinal Neoplasms; Somatostatinoma; Adenocarcinoma; Neoplasm Metastasis; Meningioma; Neoplasms; Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Carcinoid Tumor; Insulinoma; Carcinoma, Islet Cell; Stomach Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Pancreatic Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Sarcoma |
Details
|
Avapritinib |
BLU-285; CS-3007 |
Approved |
Blueprint Medicines Corp |
Ayvakyt, Ayvakit, 泰吉华 |
United States |
Gastrointestinal Stromal Tumors |
Blueprint Medicines Corp |
2020-01-09 |
Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma |
Details
|
Vorolanib |
X-82; EYP-1901; CM-082 |
Approved |
Tyrogenex Inc |
伏美纳 |
Mainland China |
Carcinoma, Renal Cell |
Betta Pharmaceuticals Co Ltd |
2023-06-07 |
Diabetic macular oedema; Carcinoma, Non-Small-Cell Lung; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Diabetic Retinopathy; Choroidal Neovascularization; Adenocarcinoma; Retinal Degeneration; Leukemia, Myeloid, Acute; Eye Diseases; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms |
Details
|
Ripretinib |
DCC-2618 |
Approved |
Deciphera |
Qinlock, 擎乐 |
United States |
Gastrointestinal Stromal Tumors |
Deciphera Pharmaceuticals Llc |
2020-05-15 |
Neoplasms; Mastocytosis, Systemic; Gastrointestinal Stromal Tumors |
Details
|
Olverembatinib |
GZD-824; APG-1351; GIBH-824; HQP-1351; D-824 |
Approved |
Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences |
耐立克 |
Mainland China |
Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase |
Guangzhou Shunjian Biomedical Technology Co Ltd |
2021-11-25 |
Solid tumours; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors |
Details
|
Ponatinib Hydrochloride |
AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 |
Approved |
Ariad |
Iclusig |
United States |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic |
Ariad Pharmaceuticals Inc |
2012-12-14 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms |
Details
|
Sunitinib Malate |
PNU-290940AD; PHA-290940AD; SCAI-003; GB-102; PNU-290940; SU-011248-L-malate salt; PHA-290940; SU-010398; SU-11248 |
Approved |
Pfizer Inc |
索坦, Sutent |
United States |
Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors |
Cppi Cv |
2006-01-26 |
Solid tumours; Fibromatosis, Aggressive; Ovarian Neoplasms; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Leukemia, Myeloid, Accelerated Phase; Leukemia; Fibrosarcoma; Teratoma; Liver Neoplasms; Ependymoma; Lymphoma, T-Cell, Peripheral; Intestinal Neoplasms; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Hemangioblastoma; Carcinoma, Islet Cell; Carcinoma; Pheochromocytoma; Stomach Neoplasms; Pelvic Neoplasms; Esophageal Neoplasms; Leukemia, Hairy Cell; Polycythemia Vera; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatoses; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Carcinoma, Papil |
Details
|
Dasatinib Hydrate |
NSC-732517; BMS-354825; XS-004 |
Approved |
Bristol-Myers Squibb Company |
施达赛, Dasynoc, Spricel, Sprycel, Spraysel |
United States |
Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic |
Bristol-Myers Squibb Company |
2006-06-28 |
Primary Myelofibrosis; Hemangiopericytoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia; Laryngeal Neoplasms; Lymphoma; Gliosarcoma; Peritoneal Neoplasms; Astrocytoma; Giant Cell Tumor of Bone; Gastrointestinal Stromal Tumors; Sarcoma, Alveolar Soft Part; Leukemia, Myeloid, Chronic-Phase; Sarcoma, Ewing; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Sarcoma; Neurofibrosarcoma; Breast Neoplasms; Brain Neoplasms; Melanoma; Leukemia, T-Cell; Carcinoma, Hepatocellular; Leukemia, Large Granular Lymphocytic; Adenocarcinoma; Mycosis Fungoides; Heart Arrest; Mastocytosis; Tongue Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Leukemia, Lymphocytic, Chronic, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Fallopian Tube Neoplasms; Lymphoma, T-Cell, Cutaneous; Uterine Neoplasms; Burkitt Lymphoma; Neoplasms, Gonadal Tissue; Intraocular Lymphoma; Lymphoma, Large-Cell, Anaplas |
Details
|
Pexidartinib |
PLX-3397 |
Approved |
Daiichi Sankyo Co Ltd |
Turalio |
United States |
Giant Cell Tumor of Tendon Sheath |
Daiichi Sankyo Inc |
2019-08-02 |
Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neurofibrosarcoma; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath |
Details
|
Pazopanib Hydrochloride |
GSK-786034; GW-786034B; SB-786034; GW-786034 |
Approved |
Glaxosmithkline Plc, Novartis Pharma Ag |
维全特, Armala, Votrient, Patorma |
United States |
Carcinoma, Renal Cell; Sarcoma |
Novartis Pharma Ag |
2009-10-19 |
Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a |
Details
|
Cabozantinib S-malate |
XL-184; BMS-907351 |
Approved |
Exelixis Inc |
Cometriq, Cabometyx |
United States |
Carcinoma, Neuroendocrine; Thyroid Neoplasms |
Exelixis Inc |
2012-11-29 |
Urethral Neoplasms; Leukemia, Myeloid, Acute; Thyroid Neoplasms; Gliosarcoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Peritoneal Neoplasms; Bile Duct Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Adenocarcinoma, Clear Cell; Sarcoma, Ewing; Carcinoma, Adenosquamous; Breast Neoplasms; Neurofibroma, Plexiform; Osteosarcoma; Prostatic Neoplasms; Sarcoma; Medullary thyroid cancer (MTC); Carcinoma, Hepatocellular; Melanoma; Paraganglioma; Meningioma; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Brain Neoplasms; Carcinoma, Neuroendocrine; Sarcoma, Alveolar Soft Part; Lymphoma; Fallopian Tube Neoplasms; Brain metastases; Glioma; Endometrial Neoplasms; Carcinoma, Squamous Cell; Carcinoid Tumor; Glioblastoma; Skin Neoplasms; Neoplasms; Carcinoma, Papillary; Hepatoblastoma; Pheochromocytoma; Pain; Rejection of liver transplantation; Carcinoma, Renal Cell; Pancreatic neuroendocrine tumors |
Details
|
Sorafenib Tosylate |
NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 |
Approved |
Onyx Pharmaceuticals Inc |
Nexavar, 多吉美 |
United States |
Carcinoma, Renal Cell |
Bayer Healthcare Pharmaceuticals Inc |
2005-12-01 |
Liver Neoplasms; Kidney Neoplasms; Recurrence; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Rhabdomyosarcoma; Lymphoma, B-Cell, Marginal Zone; Fibromatosis, Aggressive; Head and Neck Neoplasms; Solid tumours; Leiomyosarcoma; Leukemia, Myeloid; Carcinoma, Renal Cell; Carcinoma; Vipoma; Esophageal Neoplasms; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Carcinoid Tumor; Histiocytoma, Malignant Fibrous; Carcinoma, Islet Cell; Insulinoma; Stomach Neoplasms; Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Thyroid Carcinoma, Anaplastic; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Wilms Tumor; Lymphomatoid Granulomatosis; Colonic Neoplasms; Hypertension, Portal; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Multiple Endo |
Details
|
Midostaurin |
PKC-412; PKC-412A; CGP-41231; CGP-41251 |
Approved |
Novartis Pharma Ag |
Rydapt |
United States |
Mastocytosis, Systemic; Leukemia, Mast-Cell; Hematologic Neoplasms; Leukemia, Myeloid, Acute |
Novartis Pharmaceuticals Corp |
2017-04-28 |
Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis |
Details
|