0
Il n'y a pas de produit dans le panier !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Accueil > Protein > Fc gamma RI / CD64 > FCA-C52H6

Cynomolgus Fc gamma RI / CD64 Protein, His Tag (MALS & SPR verified)

Order Now

  • Synonym
    FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI
  • Source
    Cynomolgus CD64, His Tag (FCA-C52H6) is expressed from human 293 cells (HEK293). It contains AA Val 11 - Pro 288 (Accession # NP_001270969.1).
  • Molecular Characterization
    Online(Val 11 - Pro 288) NP_001270969.1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus CD64, His Tag (Cat. No. FCA-C52H6) SDS-PAGE gel

Cynomolgus CD64, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Cynomolgus CD64, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus CD64, His Tag (Cat. No. FCA-C52H6) is more than 90% and the molecular weight of this protein is around 35-52 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus CD64, His Tag (Cat. No. FCA-C52H6) captured on CM5 chip via anti-His antibody can bind Herceptin with an affinity constant of 2.34 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Comments (0)


ETA des produits en stock: 2 jours ouvrables

Price(EUR) : €220.00

Price(EUR) : €280.00

Price(EUR) : €2000.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Discontinued

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop

Laisser un message