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Cynomolgus PVRIG Protein, His Tag (MALS verified)

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  • Synonym
    C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor
  • Source
    Cynomolgus PVRIG Protein, His Tag(PVG-C52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 41 - Asp 171 (Accession # A0A2K5WVV8-1).
    Predicted N-terminus: Thr 41
  • Molecular Characterization
    PVRIG Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 15.6 kDa. The protein migrates as 20-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
PVRIG SDS-PAGE

Cynomolgus PVRIG Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
PVRIG MALS images

The purity of Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) is more than 90% and the molecular weight of this protein is around 18-28 kDa verified by SEC-MALS.

Bioactivity-ELISA
 PVRIG ELISA

Immobilized Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Nectin-2, Mouse IgG2a Fc,Avitag (Cat. No. CD2-H82A3) with a linear range of 0.3-5 ng/mL (QC tested).

 PVRIG ELISA

Immobilized Human Nectin-2, Fc Tag (Cat. No. PV2-H5253) at 5 μg/mL (100 μL/well) can bind Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) with a linear range of 0.02-0.625 μg/mL (Routinely tested).

  • Background
    Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
  • Clinical and Translational Updates

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Price(EUR) : €2330.00

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