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Your Position: Accueil > Siglec-7

Siglec-7

Brief Information

Name:Sialic acid-binding Ig-like lectin 7
Target Synonym:CDw328,AIRM-1,Adhesion inhibitory receptor molecule 1,D-siglec,QA79 membrane protein,CD328
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
SI7-H5258 Human Human Siglec-7 / CD328 Protein, Fc (L117A, L118A) Tag (MALS verified)
SI7-H5258-structure
SI7-H5258-sds
SI7-H5257 Human Human Siglec-7 / CD328 Protein, Fc (L118A, G120A, E201A) Tag (MALS verified)
SI7-H5257-structure
SI7-H5257-sds
SG7-H82E7 Human Biotinylated Human Siglec-7 / CD328 Protein, His,Avitag™ (MALS & SPR verified)
SG7-H82E7-structure
SG7-H82E7-sds
SG7-H5225 Human Human Siglec-7 / CD328 Protein, His Tag (MALS verified)
SG7-H5225-structure
SG7-H5225-sds
ACRO Quality

Part of Bioactivity data

SG7-H82E7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human Siglec-7, His,Avitag (Cat. No. SG7-H82E7) immobilized on CM5 Chip can bind Neu5Aca2-6GalNAca-PAA-biotin with an affinity constant of 29.2 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
SI7-H5257-ELISA
Siglec-7 ELISA

Immobilized Human Siglec-7, Fc (L118A, G120A, E201A) Tag (Cat. No. SI7-H5257) at 5 μg/mL (100 μL/well) can bind Neu5Aca2-6GalNAca-PAA-biotin with a linear range of 0.02-0.313 ng/mL (QC tested).

Protocol

Synonym Name

CDw328, D-siglec, A79 membrane protein, p75,Adhesion inhibitory receptor molecule 1, AIRM-1

Background

Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.

Clinical and Translational Updates

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