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Your Position: Accueil > FGF-4

FGF-4

Brief Information

Name:Fibroblast growth factor 4
Target Synonym:Fibroblast Growth Factor 4 Splice Isoform,Oncogene HST,K-FGF,KFGF,KS3,HBGF-4,Heparin-binding growth factor 4,HST,HSTF1,Fibroblast growth factor 4,FGF4,FGF-4,Transforming Protein KS3,Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene,Heparin Secretory Transforming Protein 1,Kaposi Sarcoma Oncogene,HSTF-1,HST-1,Heparin Secretory-Transforming Protein 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
FG4-H51H3 Human Human FGF-4 Protein, His Tag
FG4-H51H3-structure
FG4-H51H3-sds
ACRO Quality

Part of Bioactivity data

FG4-H51H3-SPR
FGF-4 SPR

Human FGF R4, Fc Tag (Cat. No. FG4-H5253) immobilized on CM5 Chip can bind Human FGF-4 Protein, His Tag (Cat. No. FG4-H51H3) with an affinity constant of 1.48 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
FG4-H51H3-ELISA
FGF-4 ELISA

Immobilized Human FGF-4 Protein, His Tag (Cat. No. FG4-H51H3) at 5 μg/mL (100 μL/well) can bind Human FGF R3 (IIIb), Fc Tag (Cat. No. FGB-H5259) with a linear range of 1-39 ng/mL (QC tested).

Protocol

Synonym Name

FGF-4, Fibroblast growth factor 4, HST, HST-1

Background

Fibroblast growth factor-4 (FGF4) is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions. Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. In lung adenocarcinoma (ADC) cell lines, FGF4 could alter cell morphology, promote epithelial-mesenchymal transition-associated protein expression, and enhance cell proliferation, migration/invasion and colony initiation. In B-cell lymphoma, FGF4 secretion by cancer cells induces Jag1 expression in neighbor Endothelial cell that in turn activates Notch2 in lymphoma cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Alferminogene tadenovec AGT-MI; AdFGF-4; mdFGF-4; Ad5-FGF4 Phase 3 Clinical Cardium Therapeutics Angina, Stable Details
Alferminogene tadenovec AGT-MI; AdFGF-4; mdFGF-4; Ad5-FGF4 Phase 3 Clinical Cardium Therapeutics Angina, Stable Details

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