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Cat . Non | Espèces | Description du produit | Structure | Pureté | Caractéristique |
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B71-H82F3 | Human | Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™, premium grade |
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B71-R52H9 | Rat | Rat B7-1 / CD80 Protein, His Tag (MALS verified) |
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B71-H52A4 | Human | Human B7-1 / CD80 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified) |
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B71-H82E9 | Human | Biotinylated Human B7-1 / CD80 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified) |
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B71-H82F2 | Human | Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag™ (MALS verified) |
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CD0-M5228 | Mouse | Mouse B7-1 / CD80 Protein, His Tag (MALS verified) |
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CD0-C5252 | Cynomolgus / Rhesus macaque | Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, Fc Tag (MALS verified) |
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CD0-M5259 | Mouse | Mouse B7-1 / CD80 Protein, Fc Tag (MALS verified) |
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CD0-C52H3 | Cynomolgus / Rhesus macaque | Cynomolgus / Rhesus macaque B7-1 / CD80 Protein, His Tag (MALS verified) |
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B71-H5228 | Human | Human B7-1 / CD80 Protein, His Tag (MALS verified) |
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B71-H5259 | Human | Human B7-1 / CD80 Protein, Fc Tag (MALS verified) |
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Flow Cytometry assay shows that Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) can bind to 293 cell overexpressing human CTLA-4. The concentration of Human B7-1 is 1 μg/mL (Routinely tested).
FACS analysis shows that the binding of Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) to 293 overexpressing CTLA-4 was inhibited by increasing concentration of neutralizing Anti-human CTLA-4 antibody. The concentration of Human B7-1 is 1 μg /mL. The IC50 is 5.5 μg/mL (Routinely tested).
Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) with an affinity constant of 2.72 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
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Belatacept | LEA29Y; LEA-029; BMS-224818; L104EA29YIg | Approved | Bristol-Myers Squibb Company | Nulojix | United States | Rejection of renal transplantation | Bristol-Myers Squibb Company | 2011-06-15 | Rejection of renal transplantation; Diabetes Mellitus, Type 1; Proteinuria; Pancreatic neuroendocrine tumors (pNET); Arthritis, Rheumatoid; Delayed Graft Function; Rejection of organ transplantation; Rejection in heart transplantation; Kidney Failure, Chronic | Details |
Abatacept | ONO-4164SC; BMS-188667SC; ONO-4164; BMS-188667 | Approved | Bristol-Myers Squibb Company | Orencia, 恩瑞舒 | United States | Arthritis, Rheumatoid | Bristol-Myers Squibb Company | 2005-12-23 | Arthritis, Psoriatic; Uveitis; Inflammation; Granulomatous Disease, Chronic; Urticaria; Asthma; Sjogren-Larsson Syndrome; Cardiovascular Diseases; Colitis, Ulcerative; Muscular Diseases; Glomerulosclerosis, Focal Segmental; Takayasu Arteritis; Psoriasis; Lupus Erythematosus, Systemic; Anemia, Aplastic; Nephrosis, Lipoid; Mucopolysaccharidosis I; Shwachman-Diamond Syndrome; Scleroderma, Diffuse; Common Variable Immunodeficiency; Arthralgia; Arthritis; Myocarditis; Eye Diseases; Lymphohistiocytosis, Hemophagocytic; Leukocyte-Adhesion Deficiency Syndrome; Nephrotic Syndrome; Crohn Disease; Anemia, Sickle Cell; Thrombasthenia; Behcet Syndrome; Vitiligo; Kostmann Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Arthritis, Rheumatoid; Giant Cell Arteritis; Immunoglobulin G4-Related Disease; Alopecia Areata; Dermatomyositis; Myositis; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Anemia, Diamond-Blackfan; Granulomatosis with Polyangiitis; Hematologic Diseases; Polychondritis, Relap | Details |
Belatacept | LEA29Y; LEA-029; BMS-224818; L104EA29YIg | Approved | Bristol-Myers Squibb Company | Nulojix | United States | Rejection of renal transplantation | Bristol-Myers Squibb Company | 2011-06-15 | Rejection of renal transplantation; Diabetes Mellitus, Type 1; Proteinuria; Pancreatic neuroendocrine tumors (pNET); Arthritis, Rheumatoid; Delayed Graft Function; Rejection of organ transplantation; Rejection in heart transplantation; Kidney Failure, Chronic | Details |
Abatacept | ONO-4164SC; BMS-188667SC; ONO-4164; BMS-188667 | Approved | Bristol-Myers Squibb Company | Orencia, 恩瑞舒 | United States | Arthritis, Rheumatoid | Bristol-Myers Squibb Company | 2005-12-23 | Arthritis, Psoriatic; Uveitis; Inflammation; Granulomatous Disease, Chronic; Urticaria; Asthma; Sjogren-Larsson Syndrome; Cardiovascular Diseases; Colitis, Ulcerative; Muscular Diseases; Glomerulosclerosis, Focal Segmental; Takayasu Arteritis; Psoriasis; Lupus Erythematosus, Systemic; Anemia, Aplastic; Nephrosis, Lipoid; Mucopolysaccharidosis I; Shwachman-Diamond Syndrome; Scleroderma, Diffuse; Common Variable Immunodeficiency; Arthralgia; Arthritis; Myocarditis; Eye Diseases; Lymphohistiocytosis, Hemophagocytic; Leukocyte-Adhesion Deficiency Syndrome; Nephrotic Syndrome; Crohn Disease; Anemia, Sickle Cell; Thrombasthenia; Behcet Syndrome; Vitiligo; Kostmann Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Arthritis, Rheumatoid; Giant Cell Arteritis; Immunoglobulin G4-Related Disease; Alopecia Areata; Dermatomyositis; Myositis; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Anemia, Diamond-Blackfan; Granulomatosis with Polyangiitis; Hematologic Diseases; Polychondritis, Relap | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
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Belatacept biosimilar (Alphamab) | KN-019 | Phase 2 Clinical | Suzhou Alphamab Co Ltd | Rejection of renal transplantation; Arthritis, Rheumatoid | Details |
ORCA-010 | ORCA-010 | Phase 2 Clinical | Orca Therapeutics Bv | Prostatic Neoplasms | Details |
Membrane bound ligand T-SIGn virus | NG-348 | Phase 1 Clinical | Akamis Bio Ltd | Neoplasms | Details |
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech) | Z-CTLs | Phase 1 Clinical | Hunan Zhaotai Yongren Biotech Co Ltd | Carcinoma, Non-Small-Cell Lung | Details |
Abatacept biosimilar (Dr. Reddy's Laboratories) | DRL-AB | Phase 1 Clinical | Dr.Reddy's Laboratories Ltd | Arthritis, Rheumatoid | Details |
Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio) | Phase 1 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid | Details | |
Belatacept biosimilar (Alphamab) | KN-019 | Phase 2 Clinical | Suzhou Alphamab Co Ltd | Rejection of renal transplantation; Arthritis, Rheumatoid | Details |
ORCA-010 | ORCA-010 | Phase 2 Clinical | Orca Therapeutics Bv | Prostatic Neoplasms | Details |
Membrane bound ligand T-SIGn virus | NG-348 | Phase 1 Clinical | Akamis Bio Ltd | Neoplasms | Details |
Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech) | Z-CTLs | Phase 1 Clinical | Hunan Zhaotai Yongren Biotech Co Ltd | Carcinoma, Non-Small-Cell Lung | Details |
Abatacept biosimilar (Dr. Reddy's Laboratories) | DRL-AB | Phase 1 Clinical | Dr.Reddy's Laboratories Ltd | Arthritis, Rheumatoid | Details |
Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio) | Phase 1 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid | Details |
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