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Elongin B & Elongin C & VHL

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
ELL-H5595 Human Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag (MALS&SPR verified)
ELL-H5595-sds
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Part of Bioactivity data

ELL-H5595-SPR
 Elongin B & Elongin C & VHL SPR

Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag (Cat. No. ELL-H5595) immobilized on CM5 Chip can bind MZ1 with an affinity constant of 275 μM as determined in a SPR assay (Biacore 8K) (QC tested).

ELL-H5595-MALS-HPLC
Elongin B & Elongin C & VHL MALS images

The purity of Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag (Cat. No. ELL-H5595) is more than 85% and the molecular weight of this protein is around 51-63 kDa verified by SEC-MALS.

Synonym Name

Elongin B & Elongin C & VHL, ELOB & ELOC & VHL Complex, Elongin B & Elongin C & VHL Complex

Background

Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complex--a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites.  The ELOB/ELOC complex also binds to the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families.  In this function, ELOB/ELOC serves as an adapter between substrate recognition proteins and either Cullin-2/Rbx1 (in VHL-box E3 Ubiquitin ligases) or Cullin-5/Rbx2 (in SOCS-box E3 Ubiquitin ligases). VHL is involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.

Clinical and Translational Updates

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