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Your Position: Accueil > IL-10 R alpha

IL-10 R alpha

Brief Information

Name:Interleukin 10 receptor
Target Synonym:Receptors, Interleukin-10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
ILR-M5254 Mouse Mouse IL-10 R alpha / CD210 Protein, Fc Tag
ILR-M5254-structure
ILR-M5254-sds
ILR-H525a Human Human IL-10 R alpha / CD210 Protein, Fc Tag (MALS verified)
ILR-H525a-structure
ILR-H525a-sds
ILR-C5256 Cynomolgus Cynomolgus IL-10 R alpha / CD210 Protein, Fc Tag
ILR-C5256-structure
ILR-C5256-sds
ILR-H82F6 Human Biotinylated Human IL-10 R alpha / CD210 Protein, Fc,Avitag™ (MALS verified)
ILR-H82F6-structure
ILR-H82F6-sds
ACRO Quality

Part of Bioactivity data

ILR-M5254-BLI
IL-10 R alpha BLI

Loaded Mouse IL-10, His Tag (Cat. No. IL0-M4248) on HIS1K Biosensor, can bind Mouse IL-10 R alpha Protein, Fc Tag (Cat. No. ILR-M5254) with an affinity constant of 32.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
ILR-H525a-BLI
IL-10 R alpha BLI

Loaded Human IL-10 R alpha / CD210, Fc Tag (Cat. No. ILR-H525a) on Protein A Biosensor, can bind Human IL-10, His Tag (Cat. No. IL0-H4248) with an affinity constant of 1.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

Interleukin-10 receptor subunit alpha,IL-10 receptor subunit alpha,IL-10R subunit alpha,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1,CD210,IL10RA,IL10R

Background

Interleukin-10 receptor subunit alpha (IL-10 R alpha ) is a cell surface receptor for the cytokine IL-10 that participates in IL-10 mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PEG-ilodecakin AM-0010 Phase 3 Clinical Merck Sharp & Dohme Corp, Armo Biosciences Solid tumours; Ovarian Neoplasms; Granulomatosis with Polyangiitis; Carcinoma, Renal Cell; Pancreatic Neoplasms; Neoplasms; Vasculitis; Prostatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
AG-019 AG-019 Phase 2 Clinical Precigen Actobio Inc Diabetes Mellitus, Type 1 Details
IBB-0979 IBB0979; IBB-0979 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms Details
IAE-0972 IAE-0972 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
Vimekofusp AMT-101 (Applied Molecular Transport) Phase 2 Clinical Applied Molecular Transport Colitis, Ulcerative Details
Recombinant anti-human EGFR antibody/IL-10 bispecific Fc fusion protein(Dingfu Biotarget) CmAb-(IL10)2; DF203; DF-203 Phase 1 Clinical Dingfu Biotarget Co Ltd Solid tumours Details
Diakine-DK2 10 (EGFR) DK210; DK-2-10 Phase 1 Clinical Deka Biosciences Inc Kidney Neoplasms; Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Skin Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung Details
F8-IL10 F8-IL10; PF-06687234 Phase 1 Clinical Philogen Spa Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative Details
PEG-ilodecakin AM-0010 Phase 3 Clinical Merck Sharp & Dohme Corp, Armo Biosciences Solid tumours; Ovarian Neoplasms; Granulomatosis with Polyangiitis; Carcinoma, Renal Cell; Pancreatic Neoplasms; Neoplasms; Vasculitis; Prostatic Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
AG-019 AG-019 Phase 2 Clinical Precigen Actobio Inc Diabetes Mellitus, Type 1 Details
IBB-0979 IBB0979; IBB-0979 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms Details
IAE-0972 IAE-0972 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
Vimekofusp AMT-101 (Applied Molecular Transport) Phase 2 Clinical Applied Molecular Transport Colitis, Ulcerative Details
Recombinant anti-human EGFR antibody/IL-10 bispecific Fc fusion protein(Dingfu Biotarget) CmAb-(IL10)2; DF203; DF-203 Phase 1 Clinical Dingfu Biotarget Co Ltd Solid tumours Details
Diakine-DK2 10 (EGFR) DK210; DK-2-10 Phase 1 Clinical Deka Biosciences Inc Kidney Neoplasms; Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Skin Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung Details
F8-IL10 F8-IL10; PF-06687234 Phase 1 Clinical Philogen Spa Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative Details

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