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Your Position: Accueil > Endoglin

Endoglin

Brief Information

Name:Endoglin
Target Synonym:CD105 Antigen,CD105,END,ENG,Osler-Rendu-Weber Syndrome 1,HHT1,ORW1,Endoglin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
ENN-H52H9 Human Human Endoglin / CD105 Protein, His Tag
ENN-H52H9-structure
ENN-H52H9-sds
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Synonym Name

Endoglin,CD105,ENG,END

Background

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Carotuximab DE-122; TRC-105; Chimeric Antibody TRC-105; NSC#754227 Phase 3 Clinical Roswell Park Cancer Institute Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Neoplasm Metastasis; Carcinoma, Hepatocellular; Lung Neoplasms; Trophoblastic Tumor, Placental Site; Choriocarcinoma; Fallopian Tube Neoplasms; Glioma; Adenoma, Liver Cell; Peritoneal Neoplasms; Gliosarcoma; Ureteral Neoplasms; Astrocytoma; Sarcoma; Ovarian Neoplasms; Brain Neoplasms; Breast Neoplasms; Gestational Trophoblastic Disease; Liver Neoplasms, Experimental; Prostatic Neoplasms, Castration-Resistant; Oligodendroglioma; Small Cell Lung Carcinoma; Neoplasms; Carcinoma, Transitional Cell; Glioblastoma; Hemangiosarcoma; Trophoblastic Neoplasms; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details
STEMVAC EP-101 Phase 2 Clinical Epithany Triple Negative Breast Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ENV-105 ENV-105 Phase 2 Clinical Kairos Pharma Ltd Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Carotuximab DE-122; TRC-105; Chimeric Antibody TRC-105; NSC#754227 Phase 3 Clinical Roswell Park Cancer Institute Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Neoplasm Metastasis; Carcinoma, Hepatocellular; Lung Neoplasms; Trophoblastic Tumor, Placental Site; Choriocarcinoma; Fallopian Tube Neoplasms; Glioma; Adenoma, Liver Cell; Peritoneal Neoplasms; Gliosarcoma; Ureteral Neoplasms; Astrocytoma; Sarcoma; Ovarian Neoplasms; Brain Neoplasms; Breast Neoplasms; Gestational Trophoblastic Disease; Liver Neoplasms, Experimental; Prostatic Neoplasms, Castration-Resistant; Oligodendroglioma; Small Cell Lung Carcinoma; Neoplasms; Carcinoma, Transitional Cell; Glioblastoma; Hemangiosarcoma; Trophoblastic Neoplasms; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details
STEMVAC EP-101 Phase 2 Clinical Epithany Triple Negative Breast Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ENV-105 ENV-105 Phase 2 Clinical Kairos Pharma Ltd Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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