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Claudin-6

Brief Information

Name:Claudin 6
Target Synonym:UNQ757/PRO1488,Claudin-6,CLDN6,Claudin 6,Skullin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CLDN6 mAb - 01 PCC Solid Tumor Ovarian cancer,Lung adenocarcinoma

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Part of Bioactivity data

CL6-HF2M9-Cell-based assay
 Claudin-6 CAR_T

2e5 of anti-Claudin-6 CAR-293 cells were stained with 100 μL of 1 μg/mL of Fluorescent Human Claudin-6 Protein, Flag,His,GFP Tag (Cat. No.CL6-HF2M9) and negative control protein respectively (Fig. A and B), FITC signal was used to evaluate the binding activity (QC tested).

CL6-H52P7-SPR
 Claudin-6 SPR

Human Claudin-6 Full Length Protein (VLP) (Cat. No. CL6-H52P7) captured on L1 Chip can bind Anti-Claudin-6 Antibody, Human IgG1 with an affinity constant of 57.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CL6-HF2G8-SPR
 Claudin-6 SPR

Fluorescent Human Claudin-6 Full Length Protein (VLP) (Cat. No. CL6-HF2G8) captured on L1 Chip can bind Anti-Claudin-6 Antibody, Human IgG1 with an affinity constant of 68.7 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

Claudin-6/CLDN6

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IMAB-027 ASP-1650; IMAB-027 Phase 2 Clinical Ganymed Ovarian Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal Details
BNT-142 BNT-142 Phase 2 Clinical Biontech Se Solid tumours Details
NBL-028 NBL028; NBL-028 Phase 1 Clinical Shanghai Xinshi Biological Medicine Co Ltd, Novarock Biotherapeutics Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Testicular Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XmAb-541 XmAb541; XmAb-541 Phase 1 Clinical Xencor Inc Ovarian Neoplasms; Ovarian germ cell tumor; Germinoma; Endometrial Neoplasms; Neoplasms, Germ Cell and Embryonal Details
CLDN6-CAR-NK Cell Therapy Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Ovarian Neoplasms; Testicular Neoplasms; Endometrial Neoplasms Details
DS-9606a DS-9606a; DS-9606-a Phase 1 Clinical Daiichi Sankyo Inc Ovarian Neoplasms; Neoplasms; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal Details
AMG-794 AMG-794 Phase 1 Clinical Amgen Inc Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung Details
TORL-1-23 TORL-1-23 Phase 1 Clinical Torl Biotherapeutics LLC Solid tumours; Ovarian Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
CLDN6 CAR-T cell therapy (BioNTech) BNT-211 Phase 1 Clinical Biontech Se Solid tumours Details
IMAB-027 ASP-1650; IMAB-027 Phase 2 Clinical Ganymed Ovarian Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal Details
BNT-142 BNT-142 Phase 2 Clinical Biontech Se Solid tumours Details
NBL-028 NBL028; NBL-028 Phase 1 Clinical Shanghai Xinshi Biological Medicine Co Ltd, Novarock Biotherapeutics Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Testicular Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XmAb-541 XmAb541; XmAb-541 Phase 1 Clinical Xencor Inc Ovarian Neoplasms; Ovarian germ cell tumor; Germinoma; Endometrial Neoplasms; Neoplasms, Germ Cell and Embryonal Details
CLDN6-CAR-NK Cell Therapy Phase 1 Clinical Second Affiliated Hospital Of Guangzhou Medical University Ovarian Neoplasms; Testicular Neoplasms; Endometrial Neoplasms Details
DS-9606a DS-9606a; DS-9606-a Phase 1 Clinical Daiichi Sankyo Inc Ovarian Neoplasms; Neoplasms; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal Details
AMG-794 AMG-794 Phase 1 Clinical Amgen Inc Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung Details
TORL-1-23 TORL-1-23 Phase 1 Clinical Torl Biotherapeutics LLC Solid tumours; Ovarian Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
CLDN6 CAR-T cell therapy (BioNTech) BNT-211 Phase 1 Clinical Biontech Se Solid tumours Details

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