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| Cat . Non | Espèces | Description du produit | Structure | Pureté | Caractéristique |
|---|---|---|---|---|---|
| SMO-H52P3 | Human | Human SMO Full Length Protein (VLP) |
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Sonidegib Diphosphate | LDE-225; NVP-LDE-225 | Approved | Novartis Pharma Ag | Odomzo, 奥昔朵 | United States | Carcinoma, Basal Cell | Sun Pharmaceutical Industries Ltd | 2015-07-24 | Colorectal Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Myeloproliferative Disorders; Blood Platelet Disorders; Multiple Myeloma; Basal Cell Nevus Syndrome; Prostatic Neoplasms; Breast Neoplasms; Neuroblastoma; Thrombocytosis; Primary Myelofibrosis; Pancreatic Neoplasms; Astrocytoma; Hepatic Insufficiency; Bone Marrow Diseases; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Lung Neoplasms; Glioma; Carcinoma, Hepatocellular; Thrombocythemia, Essential; Adenocarcinoma; Carcinoma, Basal Cell; Ovarian Neoplasms; Solid tumours; Hematologic Neoplasms; Rhabdomyosarcoma; Leukemia; Medulloblastoma; Blood Coagulation Disorders; Hemorrhagic Disorders; Hematologic Diseases; Leukemia, Myelogenous, Chronic; Bone Marrow Neoplasms; Esophageal Neoplasms; Polycythemia Vera; Hepatoblastoma; Stomach Neoplasms; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Fibrosis; Skin Neoplasms | Details |
| Glasdegib | PF-04; PF-4449913; PF-04449913 | Approved | Pfizer Inc | Daurismo | United States | Leukemia, Myeloid, Acute | Pfizer Inc | 2018-11-21 | Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Kidney Diseases; Neoplasms; Hepatic Insufficiency; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Fasciitis | Details |
| Vismodegib | R-3616; RG-3616; GDC-0449 | Approved | Genentech Inc, F. Hoffmann-La Roche Ltd | Erivedge | United States | Carcinoma, Basal Cell | Genentech Inc | 2012-01-30 | Gastrointestinal Stromal Tumors; Liposarcoma; Chondrosarcoma, Clear Cell; Basal Cell Nevus Syndrome; Neurofibrosarcoma; Sarcoma; Breast Neoplasms; Osteosarcoma; Sarcoma, Ewing; Prostatic Neoplasms; Brain Neoplasms; Chondrosarcoma, Extraskeletal Myxoid; Gliosarcoma; Colorectal Neoplasms; Sarcoma, Synovial; Lymphoma, Non-Hodgkin; Lymphoma; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Uterine Neoplasms; Chondrosarcoma, Mesenchymal; Leukemia, Lymphocytic, Chronic, B-Cell; Central Nervous System Lymphoma; Sarcoma, Kaposi; Neuroectodermal Tumors, Primitive, Peripheral; Adenocarcinoma; Hemangioendothelioma, Epithelioid; Stomach Neoplasms; Leiomyosarcoma; Rhabdomyosarcoma; Medulloblastoma; Ovarian Neoplasms; Chondrosarcoma; Fibrosarcoma; Hematologic Neoplasms; Carcinoma, Basal Cell; Hemangiosarcoma; Desmoplastic Small Round Cell Tumor; Mesenchymoma; Carcinoma, Renal Cell; Esophageal Neoplasms; Solid tumours; Odontogenic Cyst, Calcifying; Graft vs Host Disease; Skin Neoplasms; Lymphoma, Large B-Cell, Diffus | Details |
| Sonidegib Diphosphate | LDE-225; NVP-LDE-225 | Approved | Novartis Pharma Ag | Odomzo, 奥昔朵 | United States | Carcinoma, Basal Cell | Sun Pharmaceutical Industries Ltd | 2015-07-24 | Colorectal Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Myeloproliferative Disorders; Blood Platelet Disorders; Multiple Myeloma; Basal Cell Nevus Syndrome; Prostatic Neoplasms; Breast Neoplasms; Neuroblastoma; Thrombocytosis; Primary Myelofibrosis; Pancreatic Neoplasms; Astrocytoma; Hepatic Insufficiency; Bone Marrow Diseases; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Lung Neoplasms; Glioma; Carcinoma, Hepatocellular; Thrombocythemia, Essential; Adenocarcinoma; Carcinoma, Basal Cell; Ovarian Neoplasms; Solid tumours; Hematologic Neoplasms; Rhabdomyosarcoma; Leukemia; Medulloblastoma; Blood Coagulation Disorders; Hemorrhagic Disorders; Hematologic Diseases; Leukemia, Myelogenous, Chronic; Bone Marrow Neoplasms; Esophageal Neoplasms; Polycythemia Vera; Hepatoblastoma; Stomach Neoplasms; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Fibrosis; Skin Neoplasms | Details |
| Glasdegib | PF-04; PF-4449913; PF-04449913 | Approved | Pfizer Inc | Daurismo | United States | Leukemia, Myeloid, Acute | Pfizer Inc | 2018-11-21 | Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Kidney Diseases; Neoplasms; Hepatic Insufficiency; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Fasciitis | Details |
| Vismodegib | R-3616; RG-3616; GDC-0449 | Approved | Genentech Inc, F. Hoffmann-La Roche Ltd | Erivedge | United States | Carcinoma, Basal Cell | Genentech Inc | 2012-01-30 | Gastrointestinal Stromal Tumors; Liposarcoma; Chondrosarcoma, Clear Cell; Basal Cell Nevus Syndrome; Neurofibrosarcoma; Sarcoma; Breast Neoplasms; Osteosarcoma; Sarcoma, Ewing; Prostatic Neoplasms; Brain Neoplasms; Chondrosarcoma, Extraskeletal Myxoid; Gliosarcoma; Colorectal Neoplasms; Sarcoma, Synovial; Lymphoma, Non-Hodgkin; Lymphoma; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Uterine Neoplasms; Chondrosarcoma, Mesenchymal; Leukemia, Lymphocytic, Chronic, B-Cell; Central Nervous System Lymphoma; Sarcoma, Kaposi; Neuroectodermal Tumors, Primitive, Peripheral; Adenocarcinoma; Hemangioendothelioma, Epithelioid; Stomach Neoplasms; Leiomyosarcoma; Rhabdomyosarcoma; Medulloblastoma; Ovarian Neoplasms; Chondrosarcoma; Fibrosarcoma; Hematologic Neoplasms; Carcinoma, Basal Cell; Hemangiosarcoma; Desmoplastic Small Round Cell Tumor; Mesenchymoma; Carcinoma, Renal Cell; Esophageal Neoplasms; Solid tumours; Odontogenic Cyst, Calcifying; Graft vs Host Disease; Skin Neoplasms; Lymphoma, Large B-Cell, Diffus | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Patidegib | SGT-610; BBP-009; FIN-5; IPI-926 | Phase 3 Clinical | Infinity Pharmaceuticals Inc | Chondrosarcoma; Head and Neck Neoplasms; Carcinoma, Basal Cell; Neoplasms; Pancreatic Neoplasms; Basal Cell Nevus Syndrome; Primary Myelofibrosis; Adenocarcinoma | Details |
| Taladegib | RXDX-109; ENV-IPF-101; ENV-ONC-101; LY-2940680; ENV-101 | Phase 2 Clinical | Eli Lilly And Company | Solid tumours; Medulloblastoma; Rhabdomyosarcoma; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Cholangiocarcinoma; Sarcoma; Breast Neoplasms; Neoplasm Metastasis | Details |
| GT-1708F | GT-1708; GT1708F; GT-1708F | Phase 2 Clinical | Suzhou Koshine Biomedica Inc | Hematologic Neoplasms; Solid tumours; Idiopathic Pulmonary Fibrosis | Details |
| Cipromedegib | SHR-1539 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Solid tumours | Details |
| ZSP-1602 | ZSP-1602 | Phase 1 Clinical | Guangdong Zhongsheng Pharmaceutical Co Ltd | Medulloblastoma; Carcinoma; Carcinoma, Basal Cell; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Neuroendocrine Tumors; Glioma; Adenocarcinoma | Details |
| Patidegib | SGT-610; BBP-009; FIN-5; IPI-926 | Phase 3 Clinical | Infinity Pharmaceuticals Inc | Chondrosarcoma; Head and Neck Neoplasms; Carcinoma, Basal Cell; Neoplasms; Pancreatic Neoplasms; Basal Cell Nevus Syndrome; Primary Myelofibrosis; Adenocarcinoma | Details |
| Taladegib | RXDX-109; ENV-IPF-101; ENV-ONC-101; LY-2940680; ENV-101 | Phase 2 Clinical | Eli Lilly And Company | Solid tumours; Medulloblastoma; Rhabdomyosarcoma; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Cholangiocarcinoma; Sarcoma; Breast Neoplasms; Neoplasm Metastasis | Details |
| GT-1708F | GT-1708; GT1708F; GT-1708F | Phase 2 Clinical | Suzhou Koshine Biomedica Inc | Hematologic Neoplasms; Solid tumours; Idiopathic Pulmonary Fibrosis | Details |
| Cipromedegib | SHR-1539 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Solid tumours | Details |
| ZSP-1602 | ZSP-1602 | Phase 1 Clinical | Guangdong Zhongsheng Pharmaceutical Co Ltd | Medulloblastoma; Carcinoma; Carcinoma, Basal Cell; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Neuroendocrine Tumors; Glioma; Adenocarcinoma | Details |
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