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IL-17F

Brief Information

Name:Interleukin-17F
Target Synonym:Cytokine ML-1,Interleukin-17F,IL17F,Interleukin 17F,IL-17F,CANDF6,ML-1,ML1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

ILF-M5249-SPR
 IL-17F SPR

Human IL-17 RA, Fc Tag captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Mouse IL-17F, His Tag (Cat. No. ILF-M5249) with an affinity constant of 2.99 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILF-H5244-BLI
 IL-17F BLI

Loaded Human IL-17 RA, Fc Tag on Protein A Biosensor, can bind Human IL-17F, His Tag (Cat. No. ILF-H5244) with an affinity constant of 219 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-17F,Interleukin-17F,Cytokine ML-1

Background

Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details

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