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Human BAFF Protein, His,Flag Tag (Cat. No. BAF-H52D4) stimulates proliferation of mouse spleen cells. The EC50 for this effect is 1.97-2.90 ng/mL (Routinely tested).
Human BAFFR Protein, Fc Tag (Cat. No. BAR-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human BAFF Protein, His,Flag Tag (Cat. No. BAF-H52D4) with an affinity constant of 5.54 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Telitacicept | RCT-18; RC-18; RCT18; RC18 | Approved | RemeGen Co Ltd | 泰爱 | Mainland China | Lupus Erythematosus, Systemic | RemeGen Co Ltd | 2021-03-09 | Myasthenia Gravis; Multiple Sclerosis, Relapsing-Remitting; Glomerulonephritis, IGA; Sjogren's Syndrome; Arthritis, Rheumatoid; Multiple Sclerosis; Lupus Nephritis; Neuromyelitis Optica; Lupus Erythematosus, Systemic | Details |
Belimumab | BmAb; GSK-1550188; HGS-1006 | Approved | Glaxosmithkline Plc | Benlysta, 倍力腾 | United States | Lupus Erythematosus, Systemic | Human Genome Sciences Inc | 2011-03-09 | Glomerulonephritis, Membranous; Leukemia, Lymphocytic, Chronic, B-Cell; Pulmonary Disease, Chronic Obstructive; Emphysema; Waldenstrom Macroglobulinemia; Sjogren-Larsson Syndrome; Lymphopenia; Rheumatic Diseases; systemic sclerosis-associated interstitial lung disease; Lupus Erythematosus, Systemic; Lung Diseases, Interstitial; Myasthenia Gravis; Antiphospholipid Syndrome; Lupus Nephritis; Scleroderma, Systemic; Graft vs Host Disease; Arthritis, Rheumatoid; Purpura; Myositis; Granulomatosis with Polyangiitis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Rejection of renal transplantation | Details |
Telitacicept | RCT-18; RC-18; RCT18; RC18 | Approved | RemeGen Co Ltd | 泰爱 | Mainland China | Lupus Erythematosus, Systemic | RemeGen Co Ltd | 2021-03-09 | Myasthenia Gravis; Multiple Sclerosis, Relapsing-Remitting; Glomerulonephritis, IGA; Sjogren's Syndrome; Arthritis, Rheumatoid; Multiple Sclerosis; Lupus Nephritis; Neuromyelitis Optica; Lupus Erythematosus, Systemic | Details |
Belimumab | BmAb; GSK-1550188; HGS-1006 | Approved | Glaxosmithkline Plc | Benlysta, 倍力腾 | United States | Lupus Erythematosus, Systemic | Human Genome Sciences Inc | 2011-03-09 | Glomerulonephritis, Membranous; Leukemia, Lymphocytic, Chronic, B-Cell; Pulmonary Disease, Chronic Obstructive; Emphysema; Waldenstrom Macroglobulinemia; Sjogren-Larsson Syndrome; Lymphopenia; Rheumatic Diseases; systemic sclerosis-associated interstitial lung disease; Lupus Erythematosus, Systemic; Lung Diseases, Interstitial; Myasthenia Gravis; Antiphospholipid Syndrome; Lupus Nephritis; Scleroderma, Systemic; Graft vs Host Disease; Arthritis, Rheumatoid; Purpura; Myositis; Granulomatosis with Polyangiitis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Rejection of renal transplantation | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Atacicept | TACI-Ig | Phase 3 Clinical | Zymogenetics Inc | Glomerulonephritis, IGA; Arthritis, Rheumatoid; Multiple Sclerosis; Lupus Nephritis; Optic Neuritis; Lupus Erythematosus, Systemic | Details |
Rozibafusp alfa | AMG-570; MEDI-0700 | Phase 2 Clinical | Amgen Inc | Arthritis, Rheumatoid; Lupus Erythematosus, Systemic | Details |
Tabalumab | LY-2127399 | Phase 2 Clinical | Eli Lilly And Company | Multiple Sclerosis, Relapsing-Remitting; Dermatomyositis; Arthritis, Rheumatoid; Autoimmune Diseases; Scleroderma, Systemic; Multiple Myeloma; Connective Tissue Diseases; Arthritis, Juvenile; Multiple Sclerosis; Lupus Erythematosus, Systemic; Kidney Failure, Chronic; Pemphigus | Details |
Povetacicept | ALPN-303; ALPN 30x | Phase 2 Clinical | Alpine Immune Sciences Inc | Purpura, Thrombocytopenic, Idiopathic; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Myasthenia Gravis; Glomerulonephritis, IGA; Sjogren's Syndrome; Lupus Nephritis; Glomerulonephritis, Membranous; Lupus Erythematosus, Systemic; Anemia, Hemolytic, Autoimmune; Inflammation; Cytopenia; Glomerulonephritis | Details |
UBP-1213 | UBP-1213 | Phase 1 Clinical | Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd | Lupus Erythematosus, Systemic | Details |
Autologous CAR-T cell therapy expressing the BAFF-ligand | LMY-920; LUMT1A22 | Phase 1 Clinical | Luminary Therapeutics Inc | Sjogren's Syndrome; Scleroderma, Systemic; Multiple Myeloma; Lupus Erythematosus, Systemic; Lymphoma, Mantle-Cell | Details |
UBP1213sc | UBP1213sc | Phase 1 Clinical | Lupus Nephritis; Lupus Erythematosus, Systemic | Details | |
Atacicept | TACI-Ig | Phase 3 Clinical | Zymogenetics Inc | Glomerulonephritis, IGA; Arthritis, Rheumatoid; Multiple Sclerosis; Lupus Nephritis; Optic Neuritis; Lupus Erythematosus, Systemic | Details |
Rozibafusp alfa | AMG-570; MEDI-0700 | Phase 2 Clinical | Amgen Inc | Arthritis, Rheumatoid; Lupus Erythematosus, Systemic | Details |
Tabalumab | LY-2127399 | Phase 2 Clinical | Eli Lilly And Company | Multiple Sclerosis, Relapsing-Remitting; Dermatomyositis; Arthritis, Rheumatoid; Autoimmune Diseases; Scleroderma, Systemic; Multiple Myeloma; Connective Tissue Diseases; Arthritis, Juvenile; Multiple Sclerosis; Lupus Erythematosus, Systemic; Kidney Failure, Chronic; Pemphigus | Details |
Povetacicept | ALPN-303; ALPN 30x | Phase 2 Clinical | Alpine Immune Sciences Inc | Purpura, Thrombocytopenic, Idiopathic; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Myasthenia Gravis; Glomerulonephritis, IGA; Sjogren's Syndrome; Lupus Nephritis; Glomerulonephritis, Membranous; Lupus Erythematosus, Systemic; Anemia, Hemolytic, Autoimmune; Inflammation; Cytopenia; Glomerulonephritis | Details |
UBP-1213 | UBP-1213 | Phase 1 Clinical | Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd | Lupus Erythematosus, Systemic | Details |
Autologous CAR-T cell therapy expressing the BAFF-ligand | LMY-920; LUMT1A22 | Phase 1 Clinical | Luminary Therapeutics Inc | Sjogren's Syndrome; Scleroderma, Systemic; Multiple Myeloma; Lupus Erythematosus, Systemic; Lymphoma, Mantle-Cell | Details |
UBP1213sc | UBP1213sc | Phase 1 Clinical | Lupus Nephritis; Lupus Erythematosus, Systemic | Details |
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