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Your Position: Accueil > LILRB4

LILRB4

Brief Information

Name:Leukocyte immunoglobulin-like receptor subfamily B member 4
Target Synonym:CD85k Antigen,Leukocyte immunoglobulin-like receptor 5,Immunoglobulin-like transcript 3,CD85k,CD85 antigen-like family member K,LIR-5,Monocyte inhibitory receptor HM18,ILT-3,Leucocyte Ig-Like Receptor B4,ILT3,LIR5,Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 4,HM18,Leukocyte Immunoglobulin Like Receptor B4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CDK-M82E3 Mouse Biotinylated Mouse LILRB4 / CD85k / ILT3 Protein, His,Avitag™ (MALS verified)
CDK-M82E3-structure
CDK-M82E3-sds
CHEK-ATP088 Human HEK293/Human LILRB4 Stable Cell Line
SCCHO-ATP087 Human CHO/Human LILRB4 Stable Cell Line Development Service
LI4-H82F6 Human Biotinylated Human LILRB4 / CD85k / ILT3 Protein, Fc,Avitag™ (MALS verified)
LI4-H82F6-structure
LI4-H82F6-sds
LI4-H5257 Human Human LILRB4 / CD85k / ILT3 Protein, Mouse IgG2a Fc Tag (MALS verified)
LI4-H5257-structure
LI4-H5257-sds
LI4-H5256 Human Human LILRB4 / CD85k / ILT3 Protein, Fc Tag (MALS verified)
LI4-H5256-structure
LI4-H5256-sds
LI4-HF254 Human FITC-Labeled Human LILRB4 / CD85k / ILT3 Protein, Fc Tag
LI4-HF254-structure
LI4-HF254-sds
LI4-H82E4 Human Biotinylated Human LILRB4 / CD85k / ILT3 Protein, His,Avitag™ (MALS verified)
LI4-H82E4-structure
LI4-H82E4-sds
LI4-HF2H3 Human FITC-Labeled Human LILRB4 / CD85k / ILT3 Protein, His Tag
LI4-HF2H3-structure
LI4-HF2H3-sds
LI4-H52H7 Human Human LILRB4 / CD85k / ILT3 Protein, His Tag (MALS verified)
LI4-H52H7-structure
LI4-H52H7-sds
LI4-C5250 Cynomolgus Cynomolgus LILRB4 / CD85k / ILT3 Protein, Mouse IgG2a Fc Tag
LI4-C5250-structure
LI4-C5250-sds
CDK-M5229 Mouse Mouse LILRB4 / CD85k / ILT3 Protein, His Tag (MALS verified)
CDK-M5229-structure
CDK-M5229-sds
CDK-C5227 Cynomolgus Cynomolgus LILRB4 / CD85k / ILT3 Protein, His Tag (MALS verified)
CDK-C5227-structure
CDK-C5227-sds
CDK-C5258 Cynomolgus Cynomolgus LILRB4 / CD85k / ILT3 Protein, Fc Tag
CDK-C5258-structure
CDK-C5258-sds
ACRO Quality

Part of Bioactivity data

LI4-H52H7-SPR
LILRB4 SPR

Human ANGPTL7, His Tag immobilized on CM5 Chip can bind Human LILRB4, His Tag (Cat. No. LI4-H52H7) with an affinity constant of 4.67 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
LI4-H5257-ELISA
LILRB4 ELISA

Immobilized Human LILRB4, Mouse IgG2a Fc Tag (Cat. No. LI4-H5257) at 1 μg/mL (100 μL/well) can bind Anti-LILRB4 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Protocol

Synonym Name

LILRB4,ILT3,LIR5,CD85K,HM18

Background

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Clinical and Translational Updates

Related Molecule

ANGPTL7

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MK-0482 MK-0482 Phase 2 Clinical Merck Sharp & Dohme Corp Solid tumours; Leukemia, Myelomonocytic, Chronic; Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
IO-202 IO-202 Phase 1 Clinical Yiming Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
YTS-104 LILRB4 STAR-T; YTS-104 Phase 1 Clinical Beijing Qingyi Taike Pharmaceutical Technology Co Ltd Leukemia, Myeloid; Leukemia, Myeloid, Acute Details
BND-35 BND-35; BND35 Phase 1 Clinical Biond Biologics Ltd Solid tumours; Neoplasms Details
NGM-831 NGM-831 Phase 1 Clinical Ngm Biopharmaceuticals Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
anti-ILT3 CAR-T Therapy(Carbiogene) Phase 1 Clinical Carbiogene Therapeutics Co Ltd Leukemia, Myeloid, Acute Details
MK-0482 MK-0482 Phase 2 Clinical Merck Sharp & Dohme Corp Solid tumours; Leukemia, Myelomonocytic, Chronic; Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
IO-202 IO-202 Phase 1 Clinical Yiming Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
YTS-104 LILRB4 STAR-T; YTS-104 Phase 1 Clinical Beijing Qingyi Taike Pharmaceutical Technology Co Ltd Leukemia, Myeloid; Leukemia, Myeloid, Acute Details
BND-35 BND-35; BND35 Phase 1 Clinical Biond Biologics Ltd Solid tumours; Neoplasms Details
NGM-831 NGM-831 Phase 1 Clinical Ngm Biopharmaceuticals Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
anti-ILT3 CAR-T Therapy(Carbiogene) Phase 1 Clinical Carbiogene Therapeutics Co Ltd Leukemia, Myeloid, Acute Details

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