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Your Position: Accueil > TGF-Beta 2

TGF-Beta 2

Brief Information

Name:Transforming growth factor beta 2
Target Synonym:TGF-beta-2,BSC-1 Cell Growth Inhibitor,Polyergin,Glioblastoma-Derived T-Cell Suppressor Factor,Cetermin,LDS4,TGFB2,Transforming Growth Factor, Beta 2,Transforming Growth Factor Beta-2 Proprotein,TGF-Beta2,Transforming Growth Factor Beta 2,G-TSF,Transforming Growth Factor beta2,LAP,Prepro-Transforming Growth Factor Beta-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
TG2-H4215 Human Human TGF-Beta 2 / TGFB2 Protein, Tag Free
TG2-H4215-structure
TG2-H4215-sds
ACRO Quality

Part of Bioactivity data

TG2-H4215-ELISA
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) on Protein A Biosensor, can bind Human TGF-Beta 2, Tag Free (Cat. No. TG2-H4215) with an affinity constant of 8.09 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol

Synonym Name

TGFB2,MGC116892,TGFβ2,TGF-beta2

Background

Transforming growth factor beta 2 ( TGFB2) is also known as TGF-β2, G-TSF, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB2 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB2 protein can inhibit the T cell growth by IL-2-dependent. and can inhibit immune surveillance during tumor development, the protein promoting tumor growth with an autocrine manner. TGF-β2 can affect the viability of killer cells and reduce the expression of IL-2, IL-6, IL-10, IFN-γ and other cytokines.TGFB2 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Trabedersen OT-101; AP-2/09; AP-2/09-DS; AP-12009; OT-201 Phase 3 Clinical Glioblastoma; Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Mesothelioma; Astrocytoma; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C Phase 3 Clinical Merck Serono Lung Neoplasms; Sarcoma; Cholangiocarcinoma; Breast Neoplasms; Microsatellite Instability; Vulvar Neoplasms; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Oropharyngeal Neoplasms; Thymus Neoplasms; Gallbladder Neoplasms; Adenomyoepithelioma; Lymphoma; Brain metastases; Urogenital Neoplasms; Thymoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Sarcoma, Kaposi; Triple Negative Breast Neoplasms; Solid tumours; Hematologic Neoplasms; Head and Neck Neoplasms; Intestinal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Anus Neoplasms; Stomach Neoplasms; Carcinoma; Carcinoma, Renal Cell; Esthesioneuroblastoma, Olfactory; Biliary Tract Neoplasms; Neoplasms; Colonic Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Carcinoma, Transitional Cell; Nose Neoplasms; Ganglioglioma; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms Details
Nisevokitug NIS-793 Phase 3 Clinical Xoma Corp Kidney Neoplasms; Liver Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Small Cell Lung Carcinoma; Breast Neoplasms; Colorectal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Adenocarcinoma Details
ENERGI-F701 ENERGI-F701 Phase 2 Clinical Energenesis Biomedical Co Ltd Alopecia Details
TU-2218 TU-2218 Phase 2 Clinical TiumBio Co Ltd Solid tumours Details
LP-008 LP-008 Phase 1 Clinical Solid tumours Details
Trabedersen OT-101; AP-2/09; AP-2/09-DS; AP-12009; OT-201 Phase 3 Clinical Glioblastoma; Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Mesothelioma; Astrocytoma; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C Phase 3 Clinical Merck Serono Lung Neoplasms; Sarcoma; Cholangiocarcinoma; Breast Neoplasms; Microsatellite Instability; Vulvar Neoplasms; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Oropharyngeal Neoplasms; Thymus Neoplasms; Gallbladder Neoplasms; Adenomyoepithelioma; Lymphoma; Brain metastases; Urogenital Neoplasms; Thymoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Sarcoma, Kaposi; Triple Negative Breast Neoplasms; Solid tumours; Hematologic Neoplasms; Head and Neck Neoplasms; Intestinal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Anus Neoplasms; Stomach Neoplasms; Carcinoma; Carcinoma, Renal Cell; Esthesioneuroblastoma, Olfactory; Biliary Tract Neoplasms; Neoplasms; Colonic Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Carcinoma, Transitional Cell; Nose Neoplasms; Ganglioglioma; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms Details
Nisevokitug NIS-793 Phase 3 Clinical Xoma Corp Kidney Neoplasms; Liver Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Small Cell Lung Carcinoma; Breast Neoplasms; Colorectal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Adenocarcinoma Details
ENERGI-F701 ENERGI-F701 Phase 2 Clinical Energenesis Biomedical Co Ltd Alopecia Details
TU-2218 TU-2218 Phase 2 Clinical TiumBio Co Ltd Solid tumours Details
LP-008 LP-008 Phase 1 Clinical Solid tumours Details

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