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GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) induces cytotoxicity effect on the WEHI-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The specific activity GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) is ≥ 2.00×10^7 IU/mg, which is calibrated against human TNF-alpha WHO International Standard (NIBSC code: 12/154) (QC tested).
Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) (Cat. No. TNA-BLM494) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 75.9 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Monoclonal Anti-TNF-alpha antibody, Human IgG1 (13B8) (Cat. No. TNA-AM493) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 0.133 nM as determined in a SPR assay (Biacore 8K) (Routly tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Etanercept biosimilar (Hanwha Chemical) | HD-203; MK-8953 | Approved | Hanwha Chemical | Davictrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | ||||
| Anti-tumour necrosis factor-alpha antibody | Approved | Materia Medica Holding Research And Production Company | Artrofoon, Arthrofoon | Arthritis, Rheumatoid; Osteoarthritis | Details | |||||
| Etanercept biosimilar (AryoGen Biopharma) | Approved | Aryogen Biopharma | Altebrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |||||
| Adalimumab biosimilar (Reliance Life Sciences) | R-TPR-021 | Approved | Reliance Life Sciences | Adfrar IB | India | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Psoriasis; Arthritis, Psoriatic | Torrent Pharma, Reliance Life Sciences | 2016-01-12 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic | Details |
| Certolizumab pegol | PHA-738144; CDP-870; CZP | Approved | Ucb | 希敏佳, Cimzia, Cimziat | United States | Crohn Disease | Ucb Inc | 2008-04-22 | Non-radiographic axial spondyloarthritis; Infertility, Male; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Spondylarthropathies; Spondylarthritis; Psoriasis; Arthritis, Psoriatic; Cystitis, Interstitial; Colitis, Ulcerative; Osteoarthritis, Spine; Crohn Disease; Plaque psoriasis | Details |
| Etanercept biosimilar (Nanogen Biopharmaceutical) | Approved | Nanogen Biopharmaceutical Co | Nanercept | Vietnam | Arthritis, Rheumatoid; Psoriasis | Nanogen Biopharmaceutical Co | 2019-01-01 | Arthritis, Rheumatoid; Psoriasis | Details | |
| Infliximab Biosimilar (Genor Biopharma) | GB-242 | Approved | Genor Biopharma Co Ltd | 佳佑健 | Mainland China | Arthritis, Rheumatoid; Colitis, Ulcerative; Spondylitis, Ankylosing; Crohn Disease; Psoriasis | Yuxi Genor Biotechnology Co Ltd | 2022-02-23 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Etanercept biosimilar (Mochida) | LBEC-0101 | Approved | Mochida Pharmaceutical Co Ltd | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid | null | 2018-01-19 | Arthritis, Rheumatoid; Arthritis, Juvenile | Details | |
| Adalimumab biosimilar (Amgen) | ABP-501 | Approved | Amgen Inc | Amjevita, Amgevita, Solymbic | United States | Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid | Amgen Inc | 2016-09-23 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Juvenile; Pediatric ulcerative colitis; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis; Crohn Disease | Details |
| Etanercept biosimilar (PROBIOMED) | Approved | Probiomed | Infinitam | Mexico | Arthritis, Rheumatoid | Probiomed | 2014-01-01 | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Fresenius Kabi) | MSB-11022 | Approved | Merck Serono, Fresenius Kabi Ag | Idacio, Kromeya | EU | Crohn Disease; Uveitis; Hidradenitis Suppurativa; Psoriasis; Arthritis, Psoriatic | Fresenius Kabi Deutschland Gmbh | 2019-04-02 | Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease | Details |
| Etanercept biosimial (Sandoz) | GP-2015 | Approved | Clariant Produkte (Schweiz) Ag | Erelzi | United States | Psoriasis; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile | Sandoz | 2016-08-30 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Adalimumab biosimilar (Sinocelltech) | SCT-630 | Approved | SinoCelltech Ltd | 安佳润 | Mainland China | Arthritis, Juvenile; Crohn Disease; Pediatric Crohn's disease; Arthritis, Rheumatoid; Uveitis; Psoriasis; Spondylitis, Ankylosing | SinoCelltech Ltd | 2023-06-07 | Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease; Plaque psoriasis | Details |
| Lenalidomide | IMID-5013; CDC-5013; CDC-501; CC-5013; IMiD-3; ENMD-0997; STAR-LLD | Approved | Celgene Corp | Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo | United States | Myelodysplastic Syndromes | Bristol Myers Squibb Srlcompany | 2005-12-27 | Lymphoma, T-Cell, Peripheral; Optic Nerve Glioma; Intestinal Neoplasms; Immunoproliferative Small Intestinal Disease; Solid tumours; Bone Marrow Neoplasms; Lymphoma, B-Cell, Marginal Zone; Kidney Neoplasms; Leukemia; Liver Neoplasms; Hematologic Diseases; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid; Ependymoma; HIV Infections; Ovarian Neoplasms; Medulloblastoma; Leukemia, Hairy Cell; Anemia; Paraproteinemias; Pain; Polycythemia Vera; Plaque, Amyloid; Rhabdoid Tumor; Anemia, Refractory, with Excess of Blasts; Glioblastoma; Smoldering Multiple Myeloma; Anemia, Refractory; Lymphoma, Large B-Cell, Diffuse; Hodgkin Disease; Myelodysplastic Syndromes; Hypothalamic Neoplasms; Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Blood Protein Disorders; Graft vs Host Disease; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Acute; Nerve Degeneration; Lymphomatoid Granulomatosis; Pancreatic Neoplasms; Multiple Myeloma; Leukemia, Megakaryoblastic, Acute; Oligodend | Details |
| Etanercept biosimilar (Amega Biotech) | Approved | Amega Biotech | Enerceptan | Argentina | Arthritis, Rheumatoid | Amega Biotech | 2012-01-01 | Arthritis, Rheumatoid | Details | |
| Infliximab biosimilar (Reliance Life Sciences) | BOW-015; R-TPR-015 | Approved | Epirus Biopharmaceuticals Inc | Infimab | Arthritis, Rheumatoid | Details | ||||
| Adalimumab biosimilar (Celltrion) | CT-P17 | Approved | Celltrion Inc | Yuflyma | EU | Arthritis, Psoriatic; Psoriasis; Arthritis, Juvenile; Plaque psoriasis; Pediatric Crohn's disease; Spondylitis, Ankylosing; Pediatric ulcerative colitis; Crohn Disease; Uveitis; Arthritis, Rheumatoid; Hidradenitis Suppurativa; Colitis, Ulcerative | Celltrion Healthcare Hungary Kft | 2021-02-11 | Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis; Crohn Disease | Details |
| Etanercept biosimilar (Intas Biopharmaceuticals) | Approved | Intas Biopharmaceuticals | Intacept | India | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Intas Biopharmaceuticals | 2015-03-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |
| Infliximab biosimilar (Amgen) | ABP-710 | Approved | Amgen Inc | Avsola | United States | Pediatric ulcerative colitis; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Pediatric Crohn's disease; Plaque psoriasis | Amgen Inc | 2019-12-06 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (LG Life Sciences) | LBAL | Approved | Lg Chemical Ltd, Mochida Pharmaceutical Co Ltd | Japan | Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis, Juvenile; Colitis, Ulcerative; Spondylitis, Ankylosing; Behcet Syndrome; Uveitis, Intermediate; Uveitis, Posterior; Panuveitis; Crohn Disease | Mochida Pharmaceutical Co Ltd | 2021-03-23 | Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis, Posterior; Behcet Syndrome; Panuveitis; Crohn Disease | Details | |
| Adalimumab biosimilar (Boehringer Ingelheim) | BI-695501 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Cyltezo | United States | Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Boehringer Ingelheim Gmbh | 2017-08-25 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Golimumab | CNTO-148; rTNV148B | Approved | Johnson & Johnson Innovative Medicine | Simponi/Simponi aria, Simponi, Simponi aria | United States | Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Rheumatoid | Centocor Ortho Biotech Inc | 2009-04-24 | Non-radiographic axial spondyloarthritis; Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Colitis, Ulcerative; Arthritis, Psoriatic; Asthma; Labyrinth Diseases; Crohn Disease | Details |
| Adalimumab biosimilar (Mylan/Biocon) | BMO-2; MYL-1401-A | Approved | Biocon Ltd | United States | Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Arthritis, Psoriatic | Mylan Pharmaceuticals Inc | 2020-07-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details | |
| Luminol sodium | MP-1032 | Approved | Selvim, Metrio | Immune System Diseases; Psoriasis | null | 1997-01-01 | Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis | Details | ||
| Adalimumab biosimilar (Innovent Biologics) | IBI-303 | Approved | Innovent Biologics(Suzhou) Co Ltd | 苏立信 | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Innovent Biologics(Suzhou) Co Ltd | 2020-09-02 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease; Plaque psoriasis | Details |
| Infliximab biosimilar (Pfizer) | PF-6438179; GP-1111; PF-06438179 | Approved | Pfizer Inc | Ixifi, Zessly | EU | Pediatric Crohn's disease; Pediatric ulcerative colitis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Psoriatic | Pfizer Europe Ma Eeig | 2013-09-09 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Bio-Thera Solutions) | BAT-1406 | Approved | Bio-Thera Solutions Ltd | 格乐立 | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Uveitis; Psoriasis | Bio-Thera Solutions Ltd | 2019-11-04 | Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Alvotech) | AVT-02 (Alvotech) | Approved | Alvotech hf | SIMLANDI, Ardalicip, Ciptunec, HUKYNDRA, LIBMYRIS | EU | Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Psoriasis; Colitis, Ulcerative | Stada Arzneimittel Ag | 2021-11-12 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Colitis; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Inflammation; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Biocad) | BCD-057 | Approved | Biocad | Russian Federation | Psoriasis | Biocad | 2019-03-01 | Psoriasis | Details | |
| Adalimumab biosimilar (Shanghai Henlius Biotech) | HLX-03 | Approved | Shanghai Henlius Biotech Inc | 汉达远 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Shanghai Henlius Biotech Inc | 2020-12-02 | Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Immune System Diseases; Psoriasis; Uveitis, Posterior; Plaque psoriasis; Panuveitis | Details |
| Infliximab | TA-650 | Approved | Johnson & Johnson Innovative Medicine | Remicade, 类克, Avakine, CenTNF | United States | Crohn Disease | Centocor | 1998-08-24 | Uveitis; Vitreoretinopathy, Proliferative; Diabetic macular oedema; Visual Acuity; Pediatric ulcerative colitis; Glaucoma; Arthritis, Psoriatic; Colitis, Ulcerative; Retinal Detachment; Aneurysm; Parapsoriasis; Psoriasis; Hidradenitis Suppurativa; Granulomatous Disease, Chronic; Pulmonary Disease, Chronic Obstructive; Crohn Disease; Stevens-Johnson Syndrome; Behcet Syndrome; Diabetic Retinopathy; Melanoma; Plaque psoriasis; Pediatric Crohn's disease; Polymyositis; Inflammatory Bowel Diseases; Macular Edema; Scleritis; Dermatomyositis; Giant Cell Arteritis; Pancreatitis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Graft vs Host Disease; Non-radiographic axial spondyloarthritis; Vasculitis; Bipolar Disorder; Spondylarthropathies; Sarcoidosis; Coronavirus Disease 2019 (COVID-19); Mucocutaneous Lymph Node Syndrome; Polymyalgia Rheumatica; Stroke; Arthritis, Juvenile | Details |
| Infliximab biosimilar (Shanghai Biomabs) | CMAB-008; STI-002 | Approved | Shanghai Biomabs Pharmaceuticals Co Ltd | 百类停, 类停 | Mainland China | Arthritis, Rheumatoid; Pediatric Crohn's disease; Crohn Disease; Spondylitis, Ankylosing; Colitis, Ulcerative; Psoriasis | Taizhou Mabtech Pharmaceutical Co Ltd | 2021-07-12 | Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Infliximab biosimilar (Hisun Pharma) | HS-626 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | Mainland China | Psoriasis | Hisun Biopharmaceutical Co Ltd | 2021-09-24 | Psoriasis | Details | |
| Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) | Approved | Bionovis, The Instituto Vital Brazil | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | ||||||
| Etanercept biosimilar (Mylan) | YLB-113 | Approved | Lupin Ltd, Mylan Nv | Nepexto | EU | Plaque psoriasis; Arthritis, Juvenile; Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Psoriatic | Biosimilar Collaborations Ireland Ltd | 2020-05-20 | Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Pomalidomide | IMID-4047; CDC-394; CC-4047; IMiD-1 | Approved | Celgene Corp | Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 | United States | Multiple Myeloma | Bristol-Myers Squibb Company | 2013-02-08 | Pulmonary Fibrosis; Atypical Squamous Cells of the Cervix; Sarcoma, Kaposi; Anemia, Sickle Cell; Neurofibromatosis 1; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Waldenstrom Macroglobulinemia; Glioma; Primary Myelofibrosis; Sarcoma; Thrombocytosis; Prostatic Neoplasms; Lung Diseases, Interstitial; Medulloblastoma; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Plasmacytoma; Kidney Diseases; Pancreatic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Myeloproliferative Disorders; Graft vs Host Disease; Scleroderma, Systemic; Polycythemia Vera; Bone Marrow Neoplasms; Solid tumours | Details |
| Adalimumab biosimilar (Jiangsu Zhonghe/Shanghai Junshi/Jiangsu T-Mab) | 9MW-0113; 9MW0113; UBP-1211; 9-MW-0113; 9-MW0113 | Approved | Shanghai Junshi Biosciences Co Ltd, Jiangsu Zhonghe Pharmaceutical Technology Co Ltd, Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd, Mabwell (Shanghai) Bioscience Co Ltd | 君迈康 | Mainland China | Psoriasis; Arthritis, Rheumatoid; Spondylitis, Ankylosing | Shanghai Junshi Biosciences Co Ltd | 2022-03-01 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Samsung Bioepis) | SB-5 | Approved | Samsung Bioepis Co Ltd | Imraldi, Hadlima | EU | Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis | Samsung Bioepis Nl Bv | 2017-08-24 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) | FKB-327 | Approved | Fujifilm Kyowa Kirin Biologics Co Ltd | Hulio | EU | Colitis, Ulcerative; Crohn Disease; Uveitis; Arthritis, Psoriatic; Hidradenitis Suppurativa; Spondylitis, Ankylosing; Arthritis, Rheumatoid | Biosimilar Collaborations Ireland Ltd | 2018-09-16 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Etanercept biosimilar (Sunshine Guojian) | 301S | Approved | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd, Cipla Gmbh | Yisaipu, 益赛普, Etanar, Etacept | Mainland China | Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | 2005-06-20 | Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details |
| PG-201 | PG-201 | Approved | Viromed | Layla | South Korea | Osteoarthritis | Pmg Pharm Co Ltd | 2012-01-01 | Osteoarthritis, Knee; Osteoarthritis | Details |
| Adalimumab biosimilar (Sandoz) | GP-2017 | Approved | Sandoz | Hefiya, Hyrimoz, Halimatoz | EU | Sandoz Gmbh | 2018-07-26 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details | |
| Edaravone/(+)-2-Decanol | SIM-071201; Y-2 | Approved | Jiangsu Simcere Pharmaceutical Co Ltd | Sanbexin, 三贝心, 三贝欣 | Mainland China | Stroke | Nanjing Simcere Dongyuan Pharmaceutical Co Ltd | 2020-07-29 | Intracranial Hemorrhages; Brain Infarction; Cerebral Hemorrhage; Stroke; Alzheimer Disease; Cognitive Dysfunction; Amyotrophic Lateral Sclerosis; Cognition Disorders | Details |
| Adalimumab biosimilar (CTTQ Pharma) | TQZ-2301; TQZ2301 | Approved | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2022-01-18 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Details | |
| Infliximab biosimilar (AXXO) | Approved | Axxo | Russian Federation | Crohn Disease; Autoimmune Diseases | Axxo | 2013-01-01 | Autoimmune Diseases; Crohn Disease | Details | ||
| Infliximab biosimilar (Celltrion) | CT-P13 | Approved | Celltrion Inc | ZYMFENTRA, Remsima, Flammegis, Inflectra, Inflectra/Remsima | EU | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Psoriatic | Celltrion Healthcare Hungary Kft | 2013-09-10 | Non-radiographic axial spondyloarthritis; Inflammatory Bowel Diseases; Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Zydus Cadila) | ZRC-3197 | Approved | Zydus Cadila | Exemptia, Adaly | India | Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing | Zydus Cadila | 2014-12-09 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic | Details |
| Ozoralizumab | PF-5230896; ATN-103; PF-05230896; TS-152 | Approved | Ablynx Nv | ナノゾラ, Nanozora | Japan | Arthritis, Rheumatoid | Taisho Pharmaceutical Co Ltd | 2022-09-26 | Arthritis, Rheumatoid | Details |
| Opinercept | E-11; ENIA-11 | Approved | Tsh Biopharm, Mycenax Biotech Inc | TuNEX | Taiwan | Arthritis, Rheumatoid | null | 2017-01-01 | Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Hisun Pharma) | HS-016 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | 安健宁 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Hisun Biopharmaceutical Co Ltd | 2019-12-06 | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details |
| Infliximab biosimilar (Merck & Co/Samsung Bioepis) | SB-2 | Approved | Samsung Bioepis Co Ltd, Merck & Co Inc | Renflexis, Flixabi | EU | Crohn Disease; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Spondylitis, Ankylosing; Arthritis, Rheumatoid | Samsung Bioepis Nl Bv | 2016-05-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details |
| Andrographolide/Sodium Hydrogen Sulfite | Approved | Bacterial Infections | Details | |||||||
| Adalimumab biosimilar (Coherus BioSciences) | CHS-1420 | Approved | Coherus Biosciences Inc | Yusimry | United States | Colitis, Ulcerative; Spondylitis, Ankylosing; Crohn Disease; Plaque psoriasis; Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic | Coherus Biosciences Inc | 2021-12-17 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis | Details |
| Infliximab biosimilar (Nichiiko/Aprogen) | NI-071; GS-071; GS-07; AP-07 | Approved | Nichi-Iko Pharmaceutical Co Ltd, Aprogen | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Nichi-Iko Pharmaceutical Co Ltd | 2017-09-27 | Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | |
| Thalidomide | NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 | Approved | Celgene Corp | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Mainland China | Leprosy, Lepromatous; Multiple Myeloma | Changzhou Pharmaceutical Factory | 1982-01-01 | HIV Wasting Syndrome; Angiodysplasia; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Osteosarcoma; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Erythema Nodosum; Drug Resistant Epilepsy; Xerostomia; Sarcoma; Pancreatitis, Chronic; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Arachnoiditis; Carcinoma, Adenosquamous; Gastrointestinal Hemorrhage; Cholangitis, Sclerosing; Prostatic Neoplasms; Pelvic Pain; Neoplasm Metastasis; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Melanoma; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Tuberculosis; Appendiceal Neoplasms; Lymphoma, Non-Hodgkin; Uterine Neoplasms; Anemia, Sideroblastic; Glioma; Leprosy, Lepromatous; Endometrial Neoplasms; Lung Neoplasms; Waldenstrom Macroglobulinemia; Kidney Neoplasms; Thalassemia; Carcinoid Tumor; Lupus Erythematosus, Discoid | Details |
| Adalimumab biosimilar (Pfizer) | PF-06410293 | Approved | Pfizer Inc | Abrilada, Fyzoclad, Amsparity | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Psoriasis; Arthritis, Rheumatoid; Colitis, Ulcerative; Arthritis, Juvenile; Crohn Disease | Pfizer Inc | 2019-11-15 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) | Approved | Hisun-Pfizer | AnBaiNuo | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Wyeth Europa Ltd | 2010-02-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | |
| Adalimumab | ABT-D2E7; LU-200134; D2E7 | Approved | Abbvie Inc | Humira, Trudexa, 修美乐 | United States | Arthritis, Rheumatoid | Abbvie Inc | 2002-12-31 | Uveitis, Posterior; Glomerulosclerosis, Focal Segmental; Colitis, Ulcerative; Osteoarthritis, Knee; Cystitis, Interstitial; Arthritis, Psoriatic; Asthma; Arthritis; Uveitis; Hidradenitis Suppurativa; Mucopolysaccharidosis VI; Mucopolysaccharidosis II; Nephrotic Syndrome; Osteoarthritis; Crohn Disease; Diabetic Retinopathy; Choroidal Neovascularization; Plaque psoriasis; Panuveitis; Spondylarthritis; Pain; Prostatic Hyperplasia; Pyoderma Gangrenosum; Uveitis, Intermediate; Pouchitis; Arthritis, Rheumatoid; Pediatric Crohn's disease; Sarcoidosis; Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Dupuytren Contracture; Arthritis, Juvenile; Mucopolysaccharidosis I; Nephrosis, Lipoid; Psoriasis; Periarthritis | Details |
| Etanercept biosimilar (Qilu Pharmaceutical) | QL-0902 | Approved | Qilu Pharmaceutical Co Ltd | Mainland China | Qilu Pharmaceutical Co Ltd | 2023-12-19 | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | ||
| Etanercept biosimilar (Samsung Bioepis) | SB-4 | Approved | Samsung Bioepis Co Ltd | Eticovo, Benepali | EU | Arthritis, Psoriatic; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Plaque psoriasis | Samsung Bioepis Nl Bv | 2016-01-13 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Etanercept | TNR-001 | Approved | Amgen Inc, Pfizer Inc | Lifmior, 恩利, Enbrel | EU | Plaque psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Psoriatic; Arthritis, Juvenile | Pfizer Europe Ma Eeig | 2000-02-02 | Obesity; Pulmonary Fibrosis; Psoriasis; Myositis, Inclusion Body; Prostatic Neoplasms; Temporomandibular Joint Disorders; Arthritis, Psoriatic; Bone Neoplasms; Lichen Planus; Alzheimer Disease; Asthma; Hidradenitis Suppurativa; Respiratory Distress Syndrome, Adult; Inflammation; Cachexia; Arthritis; Lung Neoplasms; Uveitis; Plaque psoriasis; Vitiligo; Neoplasm Metastasis; Acute Lung Injury; Kidney Failure, Chronic; Stomatitis; Spondylitis, Ankylosing; Granulomatosis with Polyangiitis; Leukemia; Non-radiographic axial spondyloarthritis; Bronchiolitis Obliterans; Solid tumours; Tinnitus; HIV Infections; Lupus Erythematosus, Discoid; Rejection of lung transplantation; Arthritis, Rheumatoid; Fanconi Anemia; Diabetes Mellitus, Type 1; Vasculitis; Graft vs Host Disease; Lupus Erythematosus, Cutaneous; Synovitis; Sjogren's Syndrome; Anorexia; Metabolic Syndrome; Spondylarthritis; Chronic Urticaria; Small Cell Lung Carcinoma; Arthritis, Juvenile | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Adalimumab biosimilar (Danhong Pharma) | BC-002 | Phase 3 Clinical | Shandong Danhong Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Hetero Drugs) | Phase 3 Clinical | Hetero Drugs Ltd | Arthritis, Rheumatoid | Details | |
| Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 3 Clinical | Oncoimmune Inc | Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma | Details |
| Adalimumab biosimilar (CinnaGen) | Phase 3 Clinical | Cinnagen | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Hualan Biological Engineering) | Phase 3 Clinical | Hualan Genetic Engineering Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis | Details | |
| Etanercept biosimilar (Clover Biopharmaceuticals) | SCB-808 | Phase 3 Clinical | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Thrombocytopenia | Details | |
| Golimumab biosimilar (Bio-thera) | BAT-2506 | Phase 3 Clinical | Bio-Thera Solutions Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis | Details |
| Adalimumab biosimilar (Oncobiologics) | ONS-3010; HOT-3010; Onco-3010 | Phase 3 Clinical | Outlook Therapeutics Inc | Spondylitis, Ankylosing; Psoriasis; Arthritis; Plaque psoriasis | Details |
| Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) | Phase 3 Clinical | Wuhan Institute Of Biological Products Co Ltd | Plaque psoriasis | Details | |
| Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) | Phase 3 Clinical | Tonghua Dongbao Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Plaque psoriasis | Details | |
| Mufemilast | Hemay-005 | Phase 3 Clinical | Tianjin Hemay Pharmaceutical Co Ltd, Hainan Hailing Chemipharma Corporation Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Pulmonary Disease, Chronic Obstructive; Behcet Syndrome; Plaque psoriasis; Dermatitis, Atopic | Details |
| Tanfanercept | HBM-9036; HL-036 | Phase 3 Clinical | Hanall | Dry Eye Syndromes; Xerophthalmia | Details |
| Adalimumab biosimilar (Mabscale) | Phase 3 Clinical | Mabscale LLC | Psoriasis; Plaque psoriasis | Details | |
| Golimumab biosimilar( Alvotech) | AVT05; AV-T05 | Phase 3 Clinical | Alvotech Swiss Ag | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar(Incepta) | Phase 3 Clinical | Incepta Pharmaceuticals Ltd | Arthritis, Rheumatoid | Details | |
| Hemay007 | Hemay-007 | Phase 2 Clinical | Tianjin Hemay Bio-Tech Co Ltd | Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative | Details |
| Recombinant anti-TNFα monoclonal antibody (Livzon Group) | AT-132; LZM-001 | Phase 2 Clinical | Livzon Pharmaceutical Group Inc | Arthritis, Rheumatoid | Details |
| CC-10015 | CC-10015 | Phase 2 Clinical | Celgene Corp | Sarcoidosis; Multiple Myeloma; Lupus Erythematosus, Systemic | Details |
| EYS-606 | EYS-606 | Phase 2 Clinical | Eyevensys SAS | Uveitis | Details |
| Dovramilast | CC-11050; AMG-634 | Phase 2 Clinical | Celgene Corp | HIV Infections; Lupus Erythematosus, Cutaneous; Tuberculosis | Details |
| Licaminlimab | OCS-02; ESBA-1622; LME-636 | Phase 2 Clinical | Oculis Pharma, Alcon | Dry Eye Syndromes; Uveitis, Anterior | Details |
| XTMAB-16 | XTMAB-16 | Phase 2 Clinical | Xentria Inc | Sarcoidosis, Pulmonary | Details |
| SAR-442970 | SAR-442970 | Phase 2 Clinical | Sanofi | Inflammation; Hidradenitis Suppurativa | Details |
| Guselkumab/Golimumab | JNJ-78934804 | Phase 2 Clinical | Janssen Research & Development Llc | Colitis, Ulcerative; Crohn Disease | Details |
| Isomyosamine | MYMD-1 | Phase 2 Clinical | Mymd Pharmaceuticals Inc | Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia | Details |
| ME-3183 | ME-3183 | Phase 2 Clinical | Meiji Seika Pharma Co Ltd | Psoriasis; Plaque psoriasis | Details |
| OPS-2071 | OPS-2071 | Phase 2 Clinical | Otsuka Pharmaceutical Co Ltd | Enteritis; Irritable Bowel Syndrome; Crohn Disease | Details |
| Adalimumab biosimilar (Eastern Biotech) | JY-026 | Phase 1 Clinical | Beijing Eastern Biotech Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Crohn Disease | Details |
| Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) | Phase 1 Clinical | Qilu Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | |
| Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) | Phase 1 Clinical | North China Pharmaceutical Company Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Details | |
| Certolizumab (Intrexon) | AG-014 | Phase 1 Clinical | Intrexon Corporation | Inflammatory Bowel Diseases | Details |
| Adalimumab biosimilar (Weimingdamu Biotech) | Phase 1 Clinical | Anhui Weiming Damu Biomedicine Co Ltd | Arthritis, Rheumatoid | Details | |
| Anti-tumour necrosis factor alpha (Livzon) | Phase 1 Clinical | Livzon Pharmaceutical Group Inc | Autoimmune Diseases | Details | |
| Etanercept biosimilar (Suzhou Genemen Biotech) | BF-02; GM-02 | Phase 1 Clinical | Suzhou Genemen Biotech Co Ltd | Spondylitis, Ankylosing | Details |
| Infliximab biosimilar (Ospedale San Raffaele) | Phase 1 Clinical | Ospedale San Raffaele | Takayasu Arteritis | Details | |
| Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) | Phase 1 Clinical | Shanghai Harmony Pharmaceutical Technology Co Ltd | Details | ||
| JNJ-61178104 | JNJ-61178104 | Phase 1 Clinical | Johnson & Johnson Innovative Medicine | Autoimmune Diseases | Details |
| Adalimumab biobetter(Xencor/Zenas Biopharma) | XmAb-6755; ZB-002 | Phase 1 Clinical | Xencor Inc, Zenas BioPharma | Arthritis, Rheumatoid; Autoimmune Diseases of the Nervous System | Details |
| JNJ-63823539 | JNJ-63823539 | Phase 1 Clinical | Johnson & Johnson Innovative Medicine | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Laboratorios Richmond) | Phase 1 Clinical | Laboratorios Richmond | Details | ||
| NEX-20A | NEX-20A | Phase 1 Clinical | Nanexa AB | Multiple Myeloma | Details |
| IA-14069 | IA-14069 | Phase 1 Clinical | ILAb Co Ltd | Arthritis, Rheumatoid | Details |
| SOR-102 | SOR-102 | Phase 1 Clinical | Sorriso Pharmaceuticals Inc | Inflammatory Bowel Diseases; Colitis, Ulcerative | Details |
| Monoclonal Antibody (Mab) sB24M | Phase 1 Clinical | Swiss Biopharma Med GmbH | Pyoderma Gangrenosum; Pyoderma | Details | |
| ND-009 | ND-009 | Phase 1 Clinical | Numab Therapeutics Ag, Tillotts Pharma Ag | Inflammation | Details |
| Adalimumab biosimilar (DZM Biotech) | Phase 1 Clinical | Dzm Biotech Ltd | Arthritis, Rheumatoid | Details | |
| Igrelimogene litadenorepvec | PM-1016; PM1016; TILT-123 | Phase 1 Clinical | Tilt Biotherapeutics Ltd | Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Peritoneal Neoplasms; Lung Neoplasms; Fallopian Tube Neoplasms; Melanoma; Carcinoma, Hepatocellular | Details |
| Adalimumab biosimilar (Prestige BioPharma) | PBP-1502 | Phase 1 Clinical | Prestige BioPharma Ltd | Details | |
| Adalimumab biosimilar (AXXO) | Clinical | Axxo | Arthritis, Rheumatoid; Arthritis, Psoriatic | Details | |
| IBPM005IX (Inbiopro Solutions) | Clinical | Inbiopro Solutions | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic; Crohn Disease | Details | |
| Etanercept (Neurokine Pharmaceuticals) | NP-1; NK-001 | Clinical | Pivot Pharmaceuticals | Cognition Disorders | Details |
| Adalimumab biosimilar(BioXpress) | BX-2922; BXT-2922 | Clinical | Bioxpress Therapeutics Sa | Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Wogonin | Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University | Details |
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