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DcR3

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
DC3-H52H3 Human Human DcR3 / TNFRSF6B Protein, His Tag (MALS verified)
DC3-H52H3-structure
DC3-H52H3-sds
TNB-H5255 Human Human DcR3 / TNFRSF6B Protein, Fc Tag
TNB-H5255-structure
TNB-H5255-sds
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Part of Bioactivity data

DC3-H52H3-SPR
DcR3 SPR

Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) captured on Protein A Chip can bind Human DcR3 Protein, His Tag (Cat. No. DC3-H52H3) with an affinity constant of 21.7 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
TNB-H5255-SPR
DcR3 SPR

Human DcR3, Fc Tag (Cat. No. TNB-H5255) captured on Protein A Chip can bind Human TL1A Protein, His Tag (Cat. No. TLA-H5246) with an affinity constant of 0.497 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

TNFRSF6B,DCR3,TR6,M68

Background

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

Clinical and Translational Updates

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