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Your Position: Accueil > VCAM-1

VCAM-1

Brief Information

Name:Vascular cell adhesion molecule 1
Target Synonym:VCAM1,Vascular cell adhesion protein 1,V-CAM 1,CD106,Vascular Cell Adhesion Molecule 1,CD106 Antigen,INCAM-100,VCAM-1,Vascular Cell Adhesion Molecule-1
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
MBS-C019 Human ActiveMax® Human VCAM-1 / CD106 μBeads, premium grade (for cells)
GMP-VC1H25 Human GMP Human VCAM-1 Protein, Fc Tag
GMP-VC1H25-structure
GMP-VC1H25-sds
VC1-H82F6 Human Biotinylated Human VCAM-1 / CD106 Protein, Fc,Avitag™, premium grade
VC1-H82F6-structure
VC1-H82F6-sds
VC1-H5253 Human Human VCAM-1 / CD106 Protein, Fc Tag, premium grade
VC1-H5253-structure
VC1-H5253-sds
VC1-H5224 Human Human VCAM-1 / CD106 Protein, His Tag (MALS verified)
VC1-H5224-structure
VC1-H5224-sds
ACRO Quality

Part of Bioactivity data

GMP-VC1H25-SPR
VCAM-1 SPR

GMP Human VCAM-1 Protein, Fc Tag (Cat. No. GMP-VC1H25) captured on Protein A Chip can bind Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W1) with an affinity constant between 1.00 nM - 50.0 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
VC1-H5253-SPR
VCAM-1 SPR

Human VCAM-1 Protein, Fc Tag, premium grade (Cat. No. VC1-H5253) captured on Protein A Chip can bind Human ITGA4&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W1) with an affinity constant between 1.00 nM - 50.0 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1

Background

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tocopherol acetate DSE-9912 Approved National Institute Of Diabetes And Digestive And Kidney Diseases Ephynal, Aquasol E Japan Vitamin E Deficiency; Atherosclerosis; Venous Thromboembolism; Thrombosis; Intermittent Claudication; Diabetic Retinopathy Eisai Co Ltd 1951-09-01 Atherosclerosis; Venous Thromboembolism; Intermittent Claudication; Metabolic Dysfunction-Associated Steatotic Liver Disease; Vitamin E Deficiency; Thrombosis; Diabetic Retinopathy Details
Ascorbic Acid/Biotin/Cholecalciferol/Cyanocobalamin/Dexpanthenol/Folic acid/Niacinamide/Pyridoxine/Riboflavin/Thiamine/Tocopherol Acetate/Vitamin A/Vitamin K Approved Sandoz Canada Inc Infuvite Pediatric United States Avitaminosis Sandoz Canada Inc 2001-02-21 Avitaminosis Details
Tocopherol acetate DSE-9912 Approved National Institute Of Diabetes And Digestive And Kidney Diseases Ephynal, Aquasol E Japan Vitamin E Deficiency; Atherosclerosis; Venous Thromboembolism; Thrombosis; Intermittent Claudication; Diabetic Retinopathy Eisai Co Ltd 1951-09-01 Atherosclerosis; Venous Thromboembolism; Intermittent Claudication; Metabolic Dysfunction-Associated Steatotic Liver Disease; Vitamin E Deficiency; Thrombosis; Diabetic Retinopathy Details
Ascorbic Acid/Biotin/Cholecalciferol/Cyanocobalamin/Dexpanthenol/Folic acid/Niacinamide/Pyridoxine/Riboflavin/Thiamine/Tocopherol Acetate/Vitamin A/Vitamin K Approved Sandoz Canada Inc Infuvite Pediatric United States Avitaminosis Sandoz Canada Inc 2001-02-21 Avitaminosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
99mTccAbVCAM1‐5 99mTccAbVCAM1‐5 Phase 1 Clinical Medico-Economic Evaluation Unit , University Hospital, Grenoble Atherosclerosis Details
99mTccAbVCAM1‐5 99mTccAbVCAM1‐5 Phase 1 Clinical Medico-Economic Evaluation Unit , University Hospital, Grenoble Atherosclerosis Details

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