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Your Position: Accueil > Vitronectin

Vitronectin

Brief Information

Name:Vitronectin
Target Synonym:Vitronectin,V75,VN,Serum-spreading factor,Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein),Somatomedin B,Epibolin,Serum Spreading Factor,VNT,S-protein,Complement S-Protein,Protein S
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
GMP-VINH19 Human GMP Human Truncated Vitronectin / VTN-N Protein
GMP-VINH19-structure
GMP-VINH19-sds
VIN-H5214 Human Human Vitronectin / VTN Protein, Tag Free, low endotoxin
VIN-H5214-structure
VIN-H5214-sds
VIN-H5117 Human Human Truncated Vitronectin / VTN-N Protein, premium grade
VIN-H5117-structure
VIN-H5117-sds
ACRO Quality

Part of Bioactivity data

VIN-H5117-Cell-based assay
Vitronectin CELL

Human Vitronectin, premium grade (Cat. No. VIN-H5117) supported the adhesion of iPSC. The typical EC50 for this effect is 1414 ng/mL (Routinely tested).

Protocol
VIN-H5117-SPR
Vitronectin SPR

Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-H52E3) immobilized on CM5 Chip can bind Human Truncated Vitronectin Protein, premium grade (Cat. No. VIN-H5117) with an affinity constant of 11.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
VIN-H5214-ELISA
Vitronectin ELISA

Immobilized Human Vitronectin Protein, Tag Free (Cat. No. VIN-H5214) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse ITGAV&ITGB3 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT3-H82W3) with a linear range of 0.002-0.156 μg/mL (QC tested).

Protocol

Synonym Name

VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

Background

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Clinical and Translational Updates

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