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Syndecan-1

Brief Information

Name:Syndecan-1
Target Synonym:Syndecan Proteoglycan 1,CD138 Antigen,SYND1,SDC,Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor,Syndecan,CD138,Syndecan-1,SDC1,Syndecan 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

SY1-HA2H9-Cell-based assay
 Syndecan-1 FACS

5e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Syndecan-1 Protein, His Tag (Cat. No. SY1-HA2H9) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

SY1-H5225-Cell-based assay
 Syndecan-1 FACS

2e5 of anti-Syndecan-1 CAR-293 cells were stained with 100 μL of 3 μg/mL of Human Syndecan-1, His Tag (Cat. No. SY1-H5225) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

SY1-H5253-ELISA
 Syndecan-1 ELISA

Immobilized Human Syndecan-1, Fc Tag (Cat. No. SY1-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

SY1-H5225-ELISA
 Syndecan-1 ELISA

Immobilized Human Syndecan-1, His Tag (Cat. No. SY1-H5225) at 1 μg/mL (100 μL/well) can bind Anti-Syndecan-1 antibody, Mouse IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

Synonym Name

SDC1,Syndecan-1,CD138,SYND1,SDC

Background

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CART-138 (Chinese PLA General Hospital) Phase 2 Clinical Pla General Hospital Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Brain Neoplasms; Colorectal Neoplasms Details
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Multiple Myeloma; Immune System Diseases Details
CART-138 (Chinese PLA General Hospital) Phase 2 Clinical Pla General Hospital Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Brain Neoplasms; Colorectal Neoplasms Details
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Multiple Myeloma; Immune System Diseases Details

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