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CD96

Brief Information

Name:T-cell surface protein tactile
Target Synonym:Cell surface antigen CD96,TACTILE,T Cell Activation, Increased Late Expression,CD96 Antigen,CD96 Molecule,T cell-activated increased late expression protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

TAE-H82E3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

FACS analysis of Biotinylated Human CD96, His,Avitag binding to CD155 cells overexpressing CD155.
2e5 of CD155 cells overexpressing CD155 were stained with 100 μL of 1 μg/mL of Biotinylated Human CD96, His,Avitag (Cat. No. TAE-H82E3) and negative control protein respectively, washed and then followed by PE-SA antibody and analyzed with FACS (Routinely tested).

TAE-H52H0-Cell-based assay
 CD96 CELL

FACS analysis of Human CD96, His Tag binding to CD155 cells overexpressing CD155.

2e5 of CD155 cells overexpressing CD155 were stained with 100 μL of 1 μg/mL of Human CD96 (C110S), His Tag (Cat. No. TAE-H52H0) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

TAE-H52H0-BLI
 CD96 BLI

Loaded Human CD155, Fc Tag (Cat. No. CD5-H5251) on Protein A Biosensor, can bind Human CD96 (C110S), His Tag (Cat. No. TAE-H52H0) with an affinity constant of 625 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

TAE-H5252-ELISA
 CD96 ELISA

Immobilized Human CD96 Protein, Mouse IgG2a Fc Tag (Cat. No. TAE-H5252) at 2 μg/mL (100 μL/well) can bind Human CD155, Fc Tag (Cat. No. CD5-H5251) with a linear range of 20-312 ng/mL (QC tested).

Synonym Name

TACTILE

Background

The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AGEN-1777 AGEN-1777; BMS-986442 Phase 2 Clinical Agenus Inc Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Nelistotug GSK-6097608; GSK-608; GSK’608 CD96; GSK’608 Phase 2 Clinical Glaxosmithkline Plc Head and Neck Neoplasms; Neoplasms Details
AGEN-1777 AGEN-1777; BMS-986442 Phase 2 Clinical Agenus Inc Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Nelistotug GSK-6097608; GSK-608; GSK’608 CD96; GSK’608 Phase 2 Clinical Glaxosmithkline Plc Head and Neck Neoplasms; Neoplasms Details

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