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Galectin-9

Brief Information

Name:Galactoside-binding lectin Galectin 9
Target Synonym:Ecalectin,Tumor antigen HOM-HD-21,Galectin-9,Lectin, Galactoside-Binding, Soluble, 9,LGALS9
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
LG9-H82H3 Human Biotinylated Human Galectin-9 / LGALS9 Protein, His,Avitag™
LG9-H82H3-structure
LG9-H82H3-sds
LG9-H5244 Human Human Galectin-9 / LGALS9 Protein, His Tag
LG9-H5244-structure
LG9-H5244-sds
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Synonym Name

Galectin-9,LGALS9,Ecalectin

Background

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LYT-200 LYT-200 Phase 2 Clinical Puretech Health Solid tumours; Head and Neck Neoplasms; Myelodysplastic Syndromes; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details
LYT-200 LYT-200 Phase 2 Clinical Puretech Health Solid tumours; Head and Neck Neoplasms; Myelodysplastic Syndromes; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details

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