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Your Position: Accueil > SLC1A5

SLC1A5

Brief Information

Name:Neutral amino acid transporter B(0)
Target Synonym:ATB(0),Baboon M7 virus receptor,RD114/simian type D retrovirus receptor,Sodium-dependent neutral amino acid transporter type 2,Solute carrier family 1 member 5,ASCT2,M7V1,RDRC
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
SL5-H5149 Human Human SLC1A5 Protein, His Tag, TrxA Tag
SL5-H5149-structure
SL5-H5149-sds
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Synonym Name

ASCT2, M7V1, RDR, RDRC, ATB(0), AAAT, ASCT2M7VS1, M7V1ATBO, R16, RD114, RDRCFLJ31068

Background

Sodium-dependent amino acids transporter(SLC1A5) that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Idactamab MEDI-7247; INT-001 Phase 1 Clinical Astrazeneca Plc, Medimmune Llc Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
Idactamab MEDI-7247; INT-001 Phase 1 Clinical Astrazeneca Plc, Medimmune Llc Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details

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