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Your Position: Accueil > PDGF-BB

PDGF-BB

Brief Information

Name:Platelet-derived growth factor subunit B
Target Synonym:Epididymis Secretory Sperm Binding Protein,Becaplermin,PDGF-2,PDGFB,Platelet Derived Growth Factor Subunit B,Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog),Platelet-Derived Growth Factor B Chain,Proto-Oncogene C-Sis,PDGF Subunit B,PDGF2,SIS,Platelet-Derived Growth Factor Subunit B,Platelet-Derived Growth Factor 2,PDGF, B Chain,Oncogene SIS,IBGC5,C-Sis,SSV,Platelet-Derived Growth Factor Beta Polypeptide,Platelet-Derived Growth Factor, Beta Polypept
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
GMP-PDBH19 Human GMP Human PDGF-BB Protein
GMP-PDBH19-structure
GMP-PDBH19-sds
PDB-H4112 Human Human PDGF-BB Protein, premium grade
PDB-H4112-structure
PDB-H4112-sds
PDB-H5127 Human Unconjugated Human PDGF-BB Protein, His,Avitag™
PDB-H5127-structure
PDB-H5127-sds
ACRO Quality

Part of Bioactivity data

GMP-PDBH19-Cell-based assay
PDGF-BB CELL

GMP Human PDGF-BB Protein (Cat. No. GMP-PDBH19) stimulates proliferation of NIH/3T3 cells. The specific activity of GMP Human PDGF-BB Protein is >5.00 x 10^5 IU/mg, which is calibrated against human PDGF-BB WHO International Standard (NIBSC code: 94/728) (QC tested).

Protocol
PDB-H4112-Cell-based assay
PDGF-BB CELL

Human PDGF-BB, premium grade (Cat. No. PDB-H4112) stimulates proliferation of NIH/3T3 cells. The specific activity of Human PDGF-BB, premium grade is >5.00 x 10^5 IU/mg, which is calibrated against human PDGF-BB WHO International Standard (NIBSC code: 94/728) (QC tested).

Protocol
PDB-H5127-ELISA
PDGF-BB ELISA

Immobilized Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.5-16 ng/mL (QC tested).

Protocol
PDB-H4112-ELISA
PDGF-BB ELISA

Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 1-39 ng/mL (QC tested).

Protocol

Synonym Name

PDGF-BB,PDGF-B,FLJ12858,PDGF2,SIS,SSV,c-sis

Background

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Asengeprast SHP-627; FT-011; FT-11; FT-001 Phase 2 Clinical Fibrotech Therapeutics Pty Ltd, University Of Melbourne Scleroderma, Systemic; Scleroderma, Diffuse; Retinal Degeneration Details
Recombinant Human Platelet-derived Growth Factor B(Lynch Regenerative Medicine) rhPDGF-BB Phase 2 Clinical Lynch Regenerative Medicine LLC Rectal Fistula Details
HL-217 HL-217; KR-31831 Phase 1 Clinical Korea Research Institute Of Chemical Technology Macular Degeneration Details
REGN-13335 REGN13335; REGN-13335 Phase 1 Clinical Regeneron Pharmaceuticals Inc Details

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