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CD40

Brief Information

Name:Tumor necrosis factor receptor superfamily member 5
Target Synonym:Bp50,CD40 Antigens,CD40,B Cell Surface Antigen CD40,B-Cell Surface Antigen CD40,CDW40,CD40L Receptor,CD40 Molecule,Tumor Necrosis Factor Receptor Superfamily, Member 5,CD40 Molecule, TNF Receptor Superfamily Member 5,TNFRSF5,Tumor Necrosis Factor Receptor Superfamily Member 5,P50,CD40 Antigen,B Cell-Associated Molecule
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:42
Lastest Research Phase:Phase 2 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CD40 mAb Monospecific antibody Oncology/Cancer Advanced solid tumor Phase I Global

Product ListCompare or Buy

Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CD0-HA256 Human Alexa Fluor™ 647-Labeled Human CD40 Protein, Fc Tag (Site-specific conjugation)
CD0-HA256-structure
CD0-R52H8 Rat Rat CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-R52H8-structure
CD0-R52H8-sds
CD0-M82F3 Mouse Biotinylated Mouse CD40 / TNFRSF5 Protein, Fc,Avitag™ (MALS verified)
CD0-M82F3-structure
CD0-M82F3-sds
CD0-R52H9 Rabbit Rabbit CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-R52H9-structure
CD0-R52H9-sds
CD0-H525a Human Human CD40 / TNFRSF5 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
CD0-H525a-structure
CD0-H525a-sds
TN5-H82F9 Human Biotinylated Human CD40 / TNFRSF5 Protein, Fc,Avitag™ (MALS verified)
TN5-H82F9-structure
TN5-H82F9-sds
CD0-H82E8 Human Biotinylated Human CD40 / TNFRSF5 Protein, Avitag™,His Tag (MALS verified)
CD0-H82E8-structure
CD0-H82E8-sds
CD0-C52H6 Cynomolgus Cynomolgus CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-C52H6-structure
CD0-C52H6-sds
TN5-M52H8 Mouse Mouse CD40 / TNFRSF5 Protein, His Tag (MALS verified)
TN5-M52H8-structure
TN5-M52H8-sds
TN5-M5259 Mouse Mouse CD40 / TNFRSF5 Protein, Fc Tag
TN5-M5259-structure
TN5-M5259-sds
CD0-C5259 Rhesus macaque Rhesus macaque CD40 / TNFRSF5 Protein, Fc Tag (MALS verified)
CD0-C5259-structure
CD0-C5259-sds
CD0-C52H7 Rhesus macaque Rhesus macaque CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-C52H7-structure
CD0-C52H7-sds
CD0-H5228 Human Human CD40 / TNFRSF5 Protein, His Tag (MALS verified)
CD0-H5228-structure
CD0-H5228-sds
CD0-H5253 Human Human CD40 / TNFRSF5 Protein, Fc Tag (MALS verified)
CD0-H5253-structure
CD0-H5253-sds
ACRO Quality

Customer Reviews

Synonym Name

CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and  p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CD40L-GVAX GM.CD40L; CD40L-GVAX; GM-CSF/CD40L; hCD40L/hGM-CSF Phase 2 Clinical University Of South Florida Leukemia; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Adenocarcinoma of Lung; Lung Neoplasms; Adenocarcinoma; Melanoma Details
Giloralimab ABBV-927 Phase 2 Clinical Abbvie Inc Solid tumours; Head and Neck Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BI-655064 BI-655064 Phase 2 Clinical C.H. Boehringer Sohn Ag & Co. Kg Purpura, Thrombocytopenic, Idiopathic; Arthritis, Rheumatoid; Lupus Nephritis Details
Mitazalimab ADC-1013; JNJ-7107; JNJ-64457107 Phase 2 Clinical Alligator Bioscience Ab Solid tumours; Pancreatic Neoplasms; Neoplasms; Carcinoma, Pancreatic Ductal Details
Sotigalimab APX-005M; EPI-0050; APX-005 Phase 2 Clinical Epitomics Inc Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Skin Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Microsatellite Instability; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Iscalimab CFZ-533; NVP-CFZ533; OM11-62-MF Phase 2 Clinical Novartis Pharma Ag Rejection of renal transplantation; Myasthenia Gravis; Diabetes Mellitus, Type 1; Rejection of liver transplantation; Sjogren's Syndrome; Arthritis, Rheumatoid; Lupus Nephritis; Graves Disease; Lupus Erythematosus, Systemic; Sjogren-Larsson Syndrome; Hidradenitis Suppurativa Details
Anti-CD40 ChiLob7/4 (BioNTech) Phase 2 Clinical Biontech Se Head and Neck Neoplasms; Pancreatic Neoplasms Details
CDX-1140 CDX-1140 Phase 2 Clinical Celldex Therapeutics Colorectal Neoplasms; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Sarcoma; Breast Neoplasms; Osteosarcoma; Cholangiocarcinoma; Bile Duct Neoplasms; Peritoneal Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Squamous Cell; Waldenstrom Macroglobulinemia; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Merkel Cell; Liver Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Solid tumours; Carcinoma, Renal Cell; Carcinoma; Biliary Tract Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Uveal melanoma Details
Bleselumab 4D-11; ASKP-1240 Phase 2 Clinical Kyowa Hakko Kogyo Co Ltd Rejection of renal transplantation; Rejection of organ transplantation; Psoriasis; Glomerulosclerosis, Focal Segmental Details
Tecaginlimab BNT-312; GEN-1042 Phase 2 Clinical Genmab A/S Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Peripheral Nervous System Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Ravagalimab ABBV-323; PR-1629977 Phase 2 Clinical Abbvie Inc Sjogren's Syndrome; Colitis, Ulcerative Details
CD40.RBDv vaccin(LinKinVax) Phase 2 Clinical LinKinVax, ANRS, Emerging Infectious Diseases, Vaccine Research Institute (VRI), France Coronavirus Disease 2019 (COVID-19) Details
DFI-105 DFI105; DFI-105 Phase 2 Clinical Diabetes Free Inc Diabetes Mellitus, Type 2 Details
HPV CD40 HVac Phase 2 Clinical LinKinVax Head and Neck Neoplasms; Oropharyngeal Neoplasms Details
Cifurtilimab SEA-CD40 Phase 2 Clinical Head and Neck Neoplasms; Lymphoma, B-Cell; Squamous Cell Carcinoma of Head and Neck; Neoplasms, Squamous Cell; Pancreatic Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Lymphoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Melanoma Details
MIL-97 MIL-97 Phase 2 Clinical Beijing Mabworks Biotech Co Ltd Solid tumours; Pancreatic Neoplasms Details
Dalnicastobart LVGN7409; LVGN-7409 Phase 2 Clinical Lyvgen Biopharma(HK)Ltd Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Papillomavirus Infections; Neoplasms; Uveal melanoma; Sarcoma; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
2141-V11 2141-V11 Phase 2 Clinical The Rockefeller University Solid tumours; Ganglioglioma; Neoplasms; Skin Neoplasms; Glioblastoma; Urinary Bladder Neoplasms; Glioma Details
YH-003 YH-003; YH003 Phase 2 Clinical Eucure Pharmaceutical Technology (Beijing) Co Ltd Solid tumours; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma Details
Abiprubart KPL-404 Phase 2 Clinical Primatope Therapeutics Inc Arthritis, Rheumatoid Details
NJA-730 NJA-730; NJA-730a; NJA-730b Phase 1 Clinical Napajen Pharma Autoimmune Diseases Details
Selicrelumab RG-7876; RO-7009789 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms; Pancreatic Neoplasms; Lymphoma, Non-Hodgkin Details
Autologous IL2 and CD40 ligand-expressing tumor cells (Baylor College of Medicine) Phase 1 Clinical Baylor College Of Medicine Leukemia, Lymphocytic, Chronic, B-Cell Details
ABBV-428 ABBV-428; ABBV428 Phase 1 Clinical Abbvie Inc Solid tumours Details
MEDI-5083 MEDI-5083 Phase 1 Clinical Astrazeneca Plc, Medimmune Solid tumours Details
NG-350A NG-350A Phase 1 Clinical Akamis Bio Ltd Neoplasms, Glandular and Epithelial; Neoplasm Metastasis Details
SL-172154 SL-172154 Phase 1 Clinical Shattuck Labs Inc Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Myelodysplastic Syndromes; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute Details
LNF-1901 LNF-1901; LNF1901 Phase 1 Clinical Lunan Pharmaceutical Group Co Neoplasms Details
B-901 B-901; B901 Phase 1 Clinical FutureGen Biopharm (Beijing) Co Ltd Solid tumours Details
SHR-7367 SHR7367; SHR-7367 Phase 1 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
SHR-1704 SHR-1704 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms Details
IMB-071703 IMB-071703; IMB071703 Phase 1 Clinical Beijng Immunoah Pharma Tech Co Ltd Solid tumours Details
ILB-2101 ILB-2101 Phase 1 Clinical Innolake Biopharm (Hangzhou) Co Ltd Neoplasms Details
HBM-9027 HBM-9027; HBM9027 Phase 1 Clinical Harbour Biomed Solid tumours; Neoplasms Details
BSI-038 BSI-038 Phase 1 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Solid tumours Details
TQB-2916 TQB2916; TQB-2916 Phase 1 Clinical Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group Neoplasms Details
RO-7300490 RO-7300490; RG-6189 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details
CD40.HIVRI.Env Vaccine Phase 1 Clinical Anrs, LinKinVax HIV Infections Details
Inezetamab AMG-994 Phase 1 Clinical Amgen Inc Solid tumours Details
BMS-986325 Y 12XX-hz28-P238K Phase 1 Clinical Bristol-Myers Squibb Company Sjogren's Syndrome Details
OPT-101 Phase 1 Clinical Op-T LLC Diabetes Mellitus, Type 1 Details
NWY-001(Biocytogen Pharmaceuticals) NWY001(Biocytogen Pharmaceuticals); YH008; YH-008; NWY-001(Biocytogen Pharmaceuticals) Phase 1 Clinical Eucure Pharmaceutical Technology (Beijing) Co Ltd, Biocytogen Pharmaceuticals (Beijing) Co Ltd Solid tumours; Hematologic Neoplasms; Neoplasms Details

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