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Your Position: Accueil > GAS6

GAS6

Brief Information

Name:Growth arrest-specific protein 6
Target Synonym:GAS6,AXLLG,Growth Arrest Specific 6,AXL Receptor Tyrosine Kinase Ligand,AXL Stimulatory Factor,Growth Arrest-Specific Protein 6,GAS-6,AXSF,FLJ34709,DKFZp666G247
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
GA6-H5246 Human Human GAS6 (49-678) Protein, His Tag
GA6-H5246-structure
GA6-H5246-sds
GA6-H5247 Human Human GAS6 (471-678) Protein, His Tag (MALS verified)
GA6-H5247-structure
GA6-H5247-sds
GA6-H5249 Human Human GAS6 (279-678) Protein, His Tag (MALS verified)
GA6-H5249-structure
GA6-H5249-sds
ACRO Quality

Part of Bioactivity data

GA6-H5246-SPR
GAS6 SPR

Human Axl, Fc Tag (Cat. No. AXL-H5253) captured on Protein A Chip can bind Human GAS6 Protein, His Tag (Cat. No. GA6-H5246) with an affinity constant of 38.6 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
GA6-H5249-SPR
GAS6 SPR

Human Axl, His Tag (Cat. No. AXL-H5226) immobilized on CM5 Chip can bind Human GAS6, His Tag (Cat. No. GA6-H5249) with an affinity constant of 3.4 nM as determined in SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

GAS6,GAS-6,AXLLG

Background

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Batiraxcept AVB-500; Aravive S-6; AVB-S6-500; Ruga-S6; 3D-229; 3D229 Phase 3 Clinical Aravive Inc Ovarian Neoplasms; Solid tumours; Glomerulonephritis, IGA; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Neoplasms; Fallopian Tube Neoplasms Details
Batiraxcept AVB-500; Aravive S-6; AVB-S6-500; Ruga-S6; 3D-229; 3D229 Phase 3 Clinical Aravive Inc Ovarian Neoplasms; Solid tumours; Glomerulonephritis, IGA; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Neoplasms; Fallopian Tube Neoplasms Details

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