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Your Position: Accueil > Protein > CLEC4C > CLC-H5245

Human CLEC4C / BDCA2 Protein, His Tag

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  • Synonym
    DLEC,CLEC4C,BDCA-2,CD303,CLECSF11,CLECSF7, HECL
  • Source
    Human CLEC4C, His Tag(CLC-H5245) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).
    Predicted N-terminus: His
  • Molecular Characterization
    CLEC4C Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 26.6 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
CLEC4C SDS-PAGE

Human CLEC4C, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 CLEC4C ELISA

Immobilized Human CLEC4C, His Tag (Cat. No. CLC-H5245) at 1 μg/mL (100 μL/well) can bind Litifilimab with a linear range of 0.06-2 ng/mL (QC tested).

  • Background
    CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
  • Clinical and Translational Updates

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Price(EUR) : €350.00

Price(EUR) : €2570.00

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  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 3 Clinical

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