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Your Position: Accueil > Protein > LILRA6 > LI6-H52H3

Human LILRA6 / CD85b / ILT8 Protein, His Tag (MALS verified)

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  • Synonym
    LILRA6,CD85b,ILT8,ILT-8
  • Source
    Human LILRA6, His Tag(LI6-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asn 447 (Accession # Q6PI73-1).
    Predicted N-terminus: Gly 24
  • Molecular Characterization
    LILRA6 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 48.2 kDa. The protein migrates as 64-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
LILRA6 SDS-PAGE

Human LILRA6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
LILRA6 MALS images

The purity of Human LILRA6, His Tag (Cat. No. LI6-H52H3) is more than 85% and the molecular weight of this protein is around 49-66 kDa verified by SEC-MALS.

  • Background
    The LILRs are a family of receptors that regulate the activities of myelomonocytic cells. LILRB3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 (ILT5) and LILRA6 (ILT8) are highly polymorphic receptors with similar extracellular domains. LILRA6 can signal through association with an activating adaptor molecule, FcRγ, which bears a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif. Analysis of mR expression in the major fractions of PBMCs showed that LILRA6 is primarily expressed in monocytes, and its expression level correlates with copy number of the gene.
  • Clinical and Translational Updates

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Price(EUR) : €400.00

Price(EUR) : €2830.00

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