0
Il n'y a pas de produit dans le panier !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Accueil > Protein > MICA > MIA-C52H5

Cynomolgus MICA Protein, His Tag (HPLC verified)

Order Now

  • Synonym
    MIC-A
  • Source
    Cynomolgus MICA Protein, His Tag(MIA-C52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Trp 304 (Accession # A0A7N9D4J5).
    Predicted N-terminus: Leu 25
  • Molecular Characterization
    MICA Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 33.9 kDa. The protein migrates as 48-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
MICA SDS-PAGE

Cynomolgus MICA Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-HPLC
MICA SEC-HPLC

The purity of Cynomolgus MICA Protein, His Tag (Cat. No. MIA-C52H5) was greater than 85% as determined by SEC-HPLC.

Bioactivity-ELISA
 MICA ELISA

Immobilized Human NKG2D, Mouse IgG2a Fc Tag (Cat. No. NKD-H5259) at 2 μg/mL (100 μL/well) can bind Cynomolgus MICA Protein, His Tag (Cat. No. MIA-C52H5) with a linear range of 0.02-0.313 μg/mL (QC tested).

 MICA ELISA

Immobilized Human NKG2D Protein, Fc Tag (Cat. No. NKD-H5265) at 5 μg/mL (100 μL/well) can bind Cynomolgus MICA Protein, His Tag (Cat. No. MIA-C52H5) with a linear range of 0.008-0.25 μg/mL (Routinely tested).

 MICA ELISA

Immobilized Cynomolgus MICA Protein, His Tag (Cat. No. MIA-C52H5) at 5 μg/mL (100 μL/well) can bind Human NKG2D Protein, Fc Tag (Cat. No. NKD-H5265) with a linear range of 0.039-1.25 μg/mL (Routinely tested).

  • Background
    MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
  • Clinical and Translational Updates

Comments (0)


ETA des produits en stock: 2 jours ouvrables

Price(EUR) : €350.00

Price(EUR) : €2570.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 1 Clinical

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop

Laisser un message