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Limited Edition Golden Llama is here! Check out how you can get one. 
Limited Edition Golden Llama is here! Check out how you can get one.
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Designed under ISO 9001:2015 and ISO 13485:2016
Manufactured and QC tested under a GMP compliance factory
Animal-Free materials
Beta-lactam materials free
Batch-to-batch consistency
Stringent quality control tests
This protein carries no "tag".
The protein has a calculated MW of 15.4 kDa. The protein migrates as 16 kDa±2 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in phosphate with protectants.
Contact us for customized product form or formulation.
This product is supplied and shipped with blue ice, please inquire the shipping cost.
Upon receipt, store it immediately at -20°C or lower for long term storage.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
GMP Human IL-2 Protein on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
GMP Human IL-2 Protein (Cat. No. GMP-L02H14) stimulates proliferation of CTLL-2 cells. The specific activity of GMP Human IL-2 Protein is ≥ 1.20×10^7 IU/mg, which is calibrated against human Interleukin-2 China National Standard (NIFDC code: 270008) (QC tested). China National Institutes for Food and Drug Control (NIFDC) Standard was prepared and calibrated against human IL-2 WHO International Standard (NIBSC code: 86/500) by NIFDC.
3 × 10^6 Human PBMCs were cultured with various concentrations of GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) or IL-2 Protein (Competitor N) for a week. For the negative control group (w/o IL-2), the CD3+ ratio was 47.6%, and the CD3+ cell number was 4.8 × 10^5. The result shows that GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) has a similar activity to IL-2 Protein (Competitor N).
3 × 10^6 Human PBMCs were cultured with various concentrations of GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) or IL-2 Protein (Competitor N) for a week. For negative control group (w/o IL-2), the CD3+ CD4- CD8+ ratio was 21.7%, and the CD3+ CD4- CD8+ cell number was 1.0 × 10^5. The result shows that GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) has a similar activity to IL-2 Protein (Competitor N).
3 × 10^6 Human PBMCs were cultured with various concentrations of GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) or IL-2 Protein (Competitor N) for a week. For negative control group (w/o IL-2), the CD3+ CD4+ CD8- ratio was 72.4%, and the CD3+ CD4+ CD8- cell number was 3.5 × 10^5. The result shows that GMP Human IL-2 Protein (ACROBiosystems, Cat. No. GMP-L02H14) has a similar activity to IL-2 Protein (Competitor N).
The Cell based assay shows that GMP Human IL-2 Protein (Cat. No. GMP-L02H14) is stable at 37°C for 8 hours.
The Cell based assay shows that GMP Human IL-2 Protein (Cat. No. GMP-L02H14) is stable in the quality of different batches.
The Cell based assay shows that GMP Human IL-2 (Cat. No. GMP-L02H14) is stable after freezing and thawing 3 times.
ACROBiosystems GMP grade products are produced under a quality management system and in compliance with relevant guidelines: Ph. Eur General Chapter 5.2.12 Raw materials of biological origin for the production of cell-based and gene therapy medicinal products; USP<92>Growth Factors and Cytokines Used in Cell Therapy Manufacturing; USP<1043>Ancillary Materials for Cell, Gene, and Tissue-Engineered Products; ISO/TS 20399-1:2018, Biotechnology - Ancillary Materials Present During the Production of Cellular Therapeutic Products.
ACROBiosystems Quality Management System Contents：
Designed under ISO 9001:2015 and ISO 13485:2016, Manufactured and QC tested under a GMP compliance factory.
Animal-Free materials
Materials purchased from the approved suppliers by QA
ISO 5 clean rooms and automatic filling equipment
Qualified personnel
Quality-related documents review and approve by QA
Fully batch production and control records
Equipment maintenance and calibration
Validation of analytical procedures
Stability studies conducted
Comprehensive regulatory support files
Request For Regulatory Support Files（RSF）
ACROBiosystems provide rigorous quality control tests (fully validated equipment, processes and test methods) on our GMP grade products to ensure that they meet stringent standards in terms of purity, safety, activity and inter-batch stability, and each bulk QC lot mainly contains the following specific information:
SDS-PAGE
Protein content
Endotoxin level
Residual Host Cell DNA content
Residual Host Cell Protein content
Biological activity analysis
Microbial testing
Mycoplasma testing
In vitro virus assay
Batch-to-batch consistency
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