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CD27 Ligand

Brief Information

Name:CD70 antigen
Target Synonym:CD70 antigen,Surface Antigen CD70,LPFS3,CD27L,Tumor necrosis factor ligand superfamily member 7,CD27LG,CD27-L,CD70,CD70 Molecule,TNFSF7,Tumor Necrosis Factor (Ligand) Superfamily, Member 7,Tumor Necrosis Factor Ligand 8A,Ki-24 Antigen,TNLG8A,CD27 Ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD70 VHH - 01 Lead Hematological Malignancy Non-hodgkin lymphoma

Product ListCompare or Buy

Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CDL-HA245 Human Alexa Fluor™ 555-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HF249 Human FITC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA247 Human Alexa Fluor™ 488-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA246 Human Alexa Fluor™ 647-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HA248 Human APC-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-HP246 Human PE-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
CDL-H5255 Human Human CD27 Ligand / CD70 Protein, Llama IgG2b Fc Tag, low endotoxin
CDL-H5255-sds
CDD-HF2D4 Human FITC-Labeled Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
CDD-HF2D4-sds
CDL-H82D7 Human Biotinylated Human CD27 Ligand / CD70 Protein, His,Avitag™,Flag Tag, active trimer (MALS verified)
CDL-H82D7-sds
CDL-H52Da Human Human CD27 Ligand / CD70 Protein, His,Flag Tag, active trimer (MALS verified)
CDL-H52Da-sds
CDL-H5266 Human Human CD27 Ligand / CD70 Protein, Fc Tag, active trimer (MALS verified)
CDL-H5266-sds
CDL-M82Qb Mouse Biotinylated Mouse CD27 Ligand / CD70 Protein, His,Avitag™
CDL-M82Qb-structure
CDL-M82Qb-sds
CDL-M5245 Mouse Mouse CD27 Ligand / CD70 Protein, His Tag, active trimer (MALS verified)
CDL-M5245-structure
CDL-M5245-sds
CDL-H525a Human Human CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-H525a-structure
CDL-H525a-sds
CDL-M5251 Mouse Mouse CD27 Ligand / CD70 Protein, Mouse IgG2a Fc Tag, low endotoxin
CDL-M5251-structure
CDL-M5251-sds
ACRO Quality

Part of Bioactivity data

CDL-HA245-Cell-based assay
 CD27 Ligand CAR_T

5e5 of 293 CAR cells transfected with anti-CD27 Ligand-scFv were stained with 100 μL of 3 μg/mL of Alexa Fluor 555-Labeled Human CD27 Ligand Protein, His Tag (Cat. No. CDL-HA245) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A), Alexa 555 signal was used to evaluate the binding activity (QC tested).

CDD-HF2D4-ELISA
 CD27 Ligand ELISA

Immobilized Anti-CD27 Ligand Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) with a linear range of 0.039-0.156 μg/mL (QC tested).

CDD-HF2D4-MALS-HPLC
CD27 Ligand MALS images

The purity of FITC-Labeled Human CD27 Ligand, His,Flag Tag (Cat. No. CDD-HF2D4) is more than 85% and the molecular weight of this protein is around 55-74 kDa verified by SEC-MALS.

Synonym Name

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

Background

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cusatuzumab ARGX-110; JNJ-4550 Phase 2 Clinical Argenx Se Myelodysplastic Syndromes; Neoplasms; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
PRO-1160 PRO-1160 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Carcinoma, Renal Cell; Nasopharyngeal Carcinoma; Lymphoma; Lymphoma, Non-Hodgkin Details
CD70 Targeted CAR-T Cells Therapy(UTC Therapeutics) Phase 2 Clinical UTC Therapeutics Inc Solid tumours; Urologic Neoplasms; Lymphoma Details
MP0533 MP0533 Phase 2 Clinical Molecular Partners Ag Leukemia, Myeloid, Acute Details
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR GD2/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Lymphoma, B-Cell; Leukemia, B-Cell Details
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR PSMA/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
SEA-CD70 SEA-CD70 Phase 1 Clinical Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
BR-108 BR-108 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Leukemia; Hematologic Neoplasms Details
ARX-305 ARX-305; NCB-002 Phase 1 Clinical Neoplasms Details
Chimeric Antigen Recertor Treatment Targeting CD70(Baylor College of Medicine) Phase 1 Clinical Baylor College Of Medicine Leukemia, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, T-Cell Details
CAR T-cell Therapy Directed to CD70(St Jude Children's Research Hospital) Phase 1 Clinical St Jude Children's Research Hospital Hematologic Neoplasms; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma; Leukemia, Myeloid, Acute Details
CD70-CART(Hrain) HR010; HR-010 Phase 1 Clinical Hrain Biotechnology Co Ltd Carcinoma, Renal Cell Details
Anti-CD19/CD70 NK cell therapy (Zhejiang University) Phase 1 Clinical Zhejiang University Lymphoma, Non-Hodgkin Details
CD70 CAR-T cell therapy (Chongqing Precision Biotech) Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Neoplasms; Genital Neoplasms, Female; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
CTX-130 CTX-130 Phase 1 Clinical Crispr Therapeutics Ag Carcinoma, Renal Cell; Lymphoma, T-Cell Details
IMM-40H IMM-40H; IMM40H Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
ALLO-316 ALLO-316 Phase 1 Clinical Cellectis Sa Carcinoma, Renal Cell Details
C-4-29 Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Carcinoma, Renal Cell; Multiple Myeloma Details
Cord Blood-derived CAR NK Cells Targeting CD19/CD70(Tongji University) Tongji University Details
Cusatuzumab ARGX-110; JNJ-4550 Phase 2 Clinical Argenx Se Myelodysplastic Syndromes; Neoplasms; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
PRO-1160 PRO-1160 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Carcinoma, Renal Cell; Nasopharyngeal Carcinoma; Lymphoma; Lymphoma, Non-Hodgkin Details
CD70 Targeted CAR-T Cells Therapy(UTC Therapeutics) Phase 2 Clinical UTC Therapeutics Inc Solid tumours; Urologic Neoplasms; Lymphoma Details
MP0533 MP0533 Phase 2 Clinical Molecular Partners Ag Leukemia, Myeloid, Acute Details
GD2/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR GD2/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
CD19/70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Lymphoma, B-Cell; Leukemia, B-Cell Details
PSMA/CD70 Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR PSMA/CD70 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
SEA-CD70 SEA-CD70 Phase 1 Clinical Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
BR-108 BR-108 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Leukemia; Hematologic Neoplasms Details
ARX-305 ARX-305; NCB-002 Phase 1 Clinical Neoplasms Details
Chimeric Antigen Recertor Treatment Targeting CD70(Baylor College of Medicine) Phase 1 Clinical Baylor College Of Medicine Leukemia, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, T-Cell Details
CAR T-cell Therapy Directed to CD70(St Jude Children's Research Hospital) Phase 1 Clinical St Jude Children's Research Hospital Hematologic Neoplasms; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma; Leukemia, Myeloid, Acute Details
CD70-CART(Hrain) HR010; HR-010 Phase 1 Clinical Hrain Biotechnology Co Ltd Carcinoma, Renal Cell Details
Anti-CD19/CD70 NK cell therapy (Zhejiang University) Phase 1 Clinical Zhejiang University Lymphoma, Non-Hodgkin Details
CD70 CAR-T cell therapy (Chongqing Precision Biotech) Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Neoplasms; Genital Neoplasms, Female; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
CTX-130 CTX-130 Phase 1 Clinical Crispr Therapeutics Ag Carcinoma, Renal Cell; Lymphoma, T-Cell Details
IMM-40H IMM-40H; IMM40H Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
ALLO-316 ALLO-316 Phase 1 Clinical Cellectis Sa Carcinoma, Renal Cell Details
C-4-29 Phase 1 Clinical Chongqing Precision Biotechnology Co Ltd Carcinoma, Renal Cell; Multiple Myeloma Details
Cord Blood-derived CAR NK Cells Targeting CD19/CD70(Tongji University) Tongji University Details

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