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Cadherin-6

Brief Information

Name:Cadherin-6
Target Synonym:Kidney cadherin,K-cadherin,Cadherin 6, Type 2, K-Cadherin (Fetal Kidney),K-Cadherin,Cadherin-6,Kidney Cadherin,CAD6,KCAD
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CDH6 mAb - 01 PCC Solid Tumor Ovarian cancer,Renal cell carcinoma

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ACRO Quality

Part of Bioactivity data

CHEK-ATP127-Cell-based assay
 Cadherin-6 FACS

Expression analysis of human Cadherin-6 on HEK293/Human Cadherin-6 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human Cadherin-6 Stable Cell Line or negative control cell using anti-human Cadherin-6 antibody followed by staining with PE anti-human IgG Fc antibody.

CA6-M52H8-ELISA
 Cadherin-6 ELISA

Immobilized Mouse Cadherin-6, His Tag (Cat. No. CA6-M52H8) at 1 μg/mL (100 μL/well) can bind Human Cadherin-6 Antibody, Mouse IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

CA6-H82E3-MALS-HPLC
Cadherin-6 MALS images

The purity of Biotinylated Human Cadherin-6 Protein, His,Avitag (Cat. No. CA6-H82E3) is more than 90% and the molecular weight of this protein is around 75-100 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name

CDH6,CAD6,KCAD,K-cadherin,Cadherin-6

Background

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a  a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Raludotatug deruxtecan DS-6000a; DS6000a; DS-6000; R-DXd Phase 3 Clinical Daiichi Sankyo Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
AMT-707 AMT-707; CUSP-06 Phase 1 Clinical Multitude Therapeutics Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Cholangiocarcinoma Details
Raludotatug deruxtecan DS-6000a; DS6000a; DS-6000; R-DXd Phase 3 Clinical Daiichi Sankyo Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
AMT-707 AMT-707; CUSP-06 Phase 1 Clinical Multitude Therapeutics Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Cholangiocarcinoma Details

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