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Mouse Cadherin-6 / KCAD / CDH6 Protein, His Tag

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  • Synonym
    CDH6,CAD6,KCAD,K-cadherin,Cadherin-6
  • Source
    Mouse Cadherin-6, His Tag(CA6-M52H8) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Ala 615 (Accession # P97326-1).
    Predicted N-terminus: Thr 19
  • Molecular Characterization
    Cadherin-6 Structure

    This protein carries a polyhistidine tag at the C-terminus. The Human Cadherin-6 will be further processed into mature form (Ser 54 - Ala 615).

    The protein has a calculated MW of 68.3 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cadherin-6 SDS-PAGE

Mouse Cadherin-6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
 Cadherin-6 ELISA

Immobilized Mouse Cadherin-6, His Tag (Cat. No. CA6-M52H8) at 1 μg/mL (100 μL/well) can bind Human Cadherin-6 Antibody, Mouse IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

 Cadherin-6 ELISA

Immobilized Mouse Cadherin-6, His Tag (Cat. No. CA6-M52H8) at 1 μg/mL (100 μL/well) can bind Raludotatug with a linear range of 0.005-0.313 μg/mL (Routinely tested).

  • Background
    Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.
  • Clinical and Translational Updates

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ETA des produits en stock: 2 jours ouvrables

Price(EUR) : €350.00

Price(EUR) : €2570.00

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  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:2 Details
  • Latest Research Phase:Phase 3 Clinical

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