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uPAR

Brief Information

Name:Urokinase plasminogen activator surface receptor
Target Synonym:Monocyte activation antigen Mo3,U-PAR,uPAR,CD87,Urokinase-Type Plasminogen Activator (UPA) Receptor,URKR,U-Plasminogen Activator Receptor Form 2,CD87 Antigen,Plasminogen Activator, Urokinase Receptor,MO3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATP151-Cell-based assay
 uPAR FACS

Expression analysis of human uPAR on HEK293/Human uPAR Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human uPAR Stable Cell Line or negative control cell using PE-labeled anti-human uPAR antibody.

SCCHO-ATP152-Cell-based assay
 uPAR FACS

Expression analysis of human uPAR on CHO/Human uPAR Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human uPAR Stable Cell Line or negative control cell using PE-labeled anti-human uPAR antibody.

UPR-M5253-SPR
 uPAR SPR

Human PLAU, His Tag (Cat. No. PLU-H5229) capture on NTA-Series S sensor chip can bind Mouse uPAR Protein, Fc Tag (Cat. No. UPR-M5253) with an affinity constant of 182 nM as determined in a SPR assay (Biacore 8K) (QC tested).

UPR-C5253-SPR
 uPAR SPR

Cynomolgus uPAR Protein, Fc Tag (Cat. No. UPR-C5253) immobilized on CM5 Chip can bind Human PLAU, His Tag (Cat. No. PLU-H5229) with an affinity constant of 44.1 pM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

uPAR,PLAUR,CD87,MO3

Background

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
FG-001 FG001; FG-001 Phase 2 Clinical FluoGuide AS Head and Neck Neoplasms; Brain Neoplasms; Glioma; Lung Neoplasms; Meningioma Details
Gallium-68 NOTA AE105 (Curasight) CS-001; 68Ga-NOTA-AE105 Phase 2 Clinical Rigshospitalet, Curasight Aps Bone metastases; Head and Neck Neoplasms; Neoplasms; Glioblastoma; Urinary Bladder Neoplasms; Neuroendocrine Tumors; Mesothelioma; Prostatic Neoplasms; Breast Neoplasms; Oropharyngeal Neoplasms; Genital Neoplasms, Female; Mouth Neoplasms; Carcinoma, Non-Small-Cell Lung Details
WAL-0921 WAL0921; WAL-0921 Phase 1 Clinical Walden Biosciences Inc Renal Insufficiency, Chronic Details
MNPR-101-Zr MNPR-101-Zr; MNPR-101-DFO*-89Zr Phase 1 Clinical Monopar Therapeutics Inc, Northstar Medical Radioisotopes Llc Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
KMHH-03 KMHH-03; KMHH03 Phase 1 Clinical Beijing Kangming Haihui Biological Technology Co Ltd Breast Neoplasms Details
FG-001 FG001; FG-001 Phase 2 Clinical FluoGuide AS Head and Neck Neoplasms; Brain Neoplasms; Glioma; Lung Neoplasms; Meningioma Details
Gallium-68 NOTA AE105 (Curasight) CS-001; 68Ga-NOTA-AE105 Phase 2 Clinical Rigshospitalet, Curasight Aps Bone metastases; Head and Neck Neoplasms; Neoplasms; Glioblastoma; Urinary Bladder Neoplasms; Neuroendocrine Tumors; Mesothelioma; Prostatic Neoplasms; Breast Neoplasms; Oropharyngeal Neoplasms; Genital Neoplasms, Female; Mouth Neoplasms; Carcinoma, Non-Small-Cell Lung Details
WAL-0921 WAL0921; WAL-0921 Phase 1 Clinical Walden Biosciences Inc Renal Insufficiency, Chronic Details
MNPR-101-Zr MNPR-101-Zr; MNPR-101-DFO*-89Zr Phase 1 Clinical Monopar Therapeutics Inc, Northstar Medical Radioisotopes Llc Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
KMHH-03 KMHH-03; KMHH03 Phase 1 Clinical Beijing Kangming Haihui Biological Technology Co Ltd Breast Neoplasms Details

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