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Human uPAR / PLAUR Protein, His Tag (MALS verified)

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  • Synonym
    uPAR,PLAUR,CD87,MO3
  • Source
    Human uPAR, His Tag(UPR-H5226) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # AAH02788).
    Predicted N-terminus: Leu 23
  • Molecular Characterization
    uPAR Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
uPAR SDS-PAGE

Human uPAR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 92% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
uPAR MALS images

The purity of Human uPAR, His Tag (Cat. No. UPR-H5226) is more than 90% and the molecular weight of this protein is around 37-48 kDa verified by SEC-MALS.

Bioactivity-ELISA
 uPAR ELISA

Measured by its inhibitory ability in a competitive ELISA.

Serial dilutions of Human uPAR, His Tag (Cat. No. UPR-H5226) were added into Human PLAU, His Tag (Cat. No. PLU-H5229) : Biotinylated Human uPAR, His,Avitag (Cat. No. UPR-H82E7) binding reactions. The half maximal inhibitory concentration (IC50) is 2.96 μg/mL (QC tested).

  • Background
    Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.
  • Clinical and Translational Updates

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ETA des produits en stock: 2 jours ouvrables

Price(EUR) : €250.00

Price(EUR) : €1090.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:5 Details
  • Latest Research Phase:Phase 2 Clinical

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