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Activin RIIA

Brief Information

Name:Activin receptor type-2A
Target Synonym:Activin receptor type IIA,ACTR-IIA,ACTRIIA,ACVR2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

ACA-H5243-SPR
 Activin RIIA SPR

Human Activin RIIA Protein, His Tag (Cat. No. ACA-H5243) immobilized on CM5 Chip can bind Human Activin A Protein, premium grade (Cat. No. ACA-H5314) with an affinity constant of 85.9 pM as determined in a SPR assay (Biacore 8K) (QC tested).

ACA-M52H3-SPR
 Activin RIIA SPR

Mouse Activin RIIA Protein, His Tag (Cat. No. ACA-M52H3) capture on NTA-Series S sensor chip can bind Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) with an affinity constant of 83.8 pM as determined in a SPR assay (Biacore 8K) (QC tested).

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Synonym Name

Activin receptor type IIA,ACTRIIA

Background

Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LAE-102 LAE-102 Phase 2 Clinical Laekna Therapeutics Shanghai Co Ltd Solid tumours; Metabolic Dysfunction-Associated Steatotic Liver Disease; Carcinoma, Non-Small-Cell Lung Details
LAE-123 LAE-123 Details
LAE-102 LAE-102 Phase 2 Clinical Laekna Therapeutics Shanghai Co Ltd Solid tumours; Metabolic Dysfunction-Associated Steatotic Liver Disease; Carcinoma, Non-Small-Cell Lung Details
LAE-123 LAE-123 Details

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