0
Il n'y a pas de produit dans le panier !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Accueil > IL-17A

IL-17A

Brief Information

Name:Interleukin 17A
Target Synonym:Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8),CTLA8,IL17A,Interleukin 17A,Cytotoxic T-Lymphocyte-Associated Antigen 8,Cytotoxic T-Lymphocyte-Associated Protein 8,CTLA-8,IL-17A,IL-17,IL17,Interleukin-17A
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:29
Lastest Research Phase:Approved

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
IL17A mAb Monospecific antibody Immunological disease Psoriasis,Axial spondyloarthritis SpA Phase III Global  (except China)

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

ILA-H5219-Cell-based assay
 IL-17A CELL

Human IL-17A, premium grade (Cat. No. ILA-H5219) stimulates proliferation of 293F-NFKB/luc-IL17-30 cell line. The specific activity of Human IL-17A, premium grade is > 1.00ⅹ10^7 IU/mg, which is calibrated against human IL-17 WHO International Standard (NIBSC code: 01/420) (QC tested).

CT8-M5240-Cell-based assay
 IL-17A CELL

Mouse IL-17A, His Tag (Cat. No. CT8-M5240) stimulates secretion of IL-6 by NIH-3T3 cells. The ED50 for this effect is 2.132-5.005 ng/mL.

ILA-H5243-SPR
 IL-17A SPR

Human IL-17 RA Protein, Fc Tag (Cat. No. ILA-H525f) captured on Protein A Chip can bind Human IL-17A Protein, His Tag (Cat. No. ILA-H5243) with an affinity constant of 0.360 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILA-H82Q1-BLI
 IL-17A BLI

Loaded Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) on SA Biosensor, can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with an affinity constant of 18.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-17A,Interleukin-17A,CTLA-8,IL-17

Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ixekizumab LY-2439821 Approved Eli Lilly And Company 拓咨, Taltz United States Psoriasis Eli Lilly And Company 2016-03-22 Diabetes Mellitus, Type 1; Non-radiographic axial spondyloarthritis; Depressive Disorder, Major; Pyoderma Gangrenosum; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Lichen Planus; Pemphigoid, Bullous; Pityriasis Rubra Pilaris; Plaque psoriasis Details
Virulizin Approved Aptose Virulizin, Virulizin-2 gamma Mexico Sarcoma, Kaposi; Melanoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms null 1997-01-01 Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Sarcoma, Kaposi; Melanoma; Uterine Cervical Neoplasms Details
Secukinumab NVP-AIN-457; AIN-457; KB-03303A Approved Novartis Pharma Ag 可善挺, Scapho, Cosentyx Japan Arthritis, Psoriatic; Psoriasis Novartis Pharma Ag 2014-12-26 Hidradenitis Suppurativa; Polymyalgia Rheumatica; Ichthyosis, Lamellar; Psoriasis; Tendinopathy; Hyperkeratosis, Epidermolytic; Arthritis, Psoriatic; Tendon Injuries; Asthma; Lichen Planus; Arthritis, Juvenile; Uveitis; Arthritis; Inflammation; Plaque psoriasis; Behcet Syndrome; Crohn Disease; Gastroenteritis; Dermatitis, Atopic; Ichthyosiform Erythroderma, Congenital; Spondylitis, Ankylosing; Non-radiographic axial spondyloarthritis; Necrobiosis Lipoidica; Diabetes Mellitus, Type 1; Giant Cell Arteritis; Alopecia Areata; Pyoderma Gangrenosum; Lupus Erythematosus, Discoid; Metabolic Dysfunction-Associated Steatotic Liver Disease; Inflammatory Bowel Diseases; Multiple Sclerosis, Relapsing-Remitting; Rotator Cuff Injuries; Spondylarthritis; Arthritis, Rheumatoid; Spondylarthropathies; Netherton Syndrome; Ichthyosis; Lupus Nephritis; Graves Ophthalmopathy; Multiple Sclerosis Details
Ixekizumab LY-2439821 Approved Eli Lilly And Company 拓咨, Taltz United States Psoriasis Eli Lilly And Company 2016-03-22 Diabetes Mellitus, Type 1; Non-radiographic axial spondyloarthritis; Depressive Disorder, Major; Pyoderma Gangrenosum; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Lichen Planus; Pemphigoid, Bullous; Pityriasis Rubra Pilaris; Plaque psoriasis Details
Virulizin Approved Aptose Virulizin, Virulizin-2 gamma Mexico Sarcoma, Kaposi; Melanoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms null 1997-01-01 Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Sarcoma, Kaposi; Melanoma; Uterine Cervical Neoplasms Details
Secukinumab NVP-AIN-457; AIN-457; KB-03303A Approved Novartis Pharma Ag 可善挺, Scapho, Cosentyx Japan Arthritis, Psoriatic; Psoriasis Novartis Pharma Ag 2014-12-26 Hidradenitis Suppurativa; Polymyalgia Rheumatica; Ichthyosis, Lamellar; Psoriasis; Tendinopathy; Hyperkeratosis, Epidermolytic; Arthritis, Psoriatic; Tendon Injuries; Asthma; Lichen Planus; Arthritis, Juvenile; Uveitis; Arthritis; Inflammation; Plaque psoriasis; Behcet Syndrome; Crohn Disease; Gastroenteritis; Dermatitis, Atopic; Ichthyosiform Erythroderma, Congenital; Spondylitis, Ankylosing; Non-radiographic axial spondyloarthritis; Necrobiosis Lipoidica; Diabetes Mellitus, Type 1; Giant Cell Arteritis; Alopecia Areata; Pyoderma Gangrenosum; Lupus Erythematosus, Discoid; Metabolic Dysfunction-Associated Steatotic Liver Disease; Inflammatory Bowel Diseases; Multiple Sclerosis, Relapsing-Remitting; Rotator Cuff Injuries; Spondylarthritis; Arthritis, Rheumatoid; Spondylarthropathies; Netherton Syndrome; Ichthyosis; Lupus Nephritis; Graves Ophthalmopathy; Multiple Sclerosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SSGJ-608 608; SSGJ-608 Phase 3 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Spondylarthritis; Psoriasis; Plaque psoriasis Details
QX002N QX-002N Phase 3 Clinical Qyuns Therapeutics Co Ltd Spondylitis, Ankylosing; Asthma Details
Roconkibart JS005 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Gumokimab AK-111 Phase 3 Clinical Zhongshan Akeso Biopharma Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Skin Diseases; Psoriasis; Plaque psoriasis Details
Izokibep IMG-020; IMG020; ABY-035; AFB-035 Phase 3 Clinical Affibody Ab Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Secukinumab biosimilar (Bio-Thera Solutions) BAT-2306 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
CJM-112 CJM-112 Phase 2 Clinical Novartis Pharma Ag Acne Vulgaris; Triple Negative Breast Neoplasms; Multiple Sclerosis; Multiple Myeloma; Psoriasis; Asthma; Colorectal Neoplasms; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
SIM-0335 SIM-0335; SIM-335 Phase 2 Clinical BCY Pharm Co Ltd Plaque psoriasis Details
SCT-650C SCT650C; SCT-650-C; SCT-650C Phase 2 Clinical SinoCelltech Ltd Non-radiographic axial spondyloarthritis; Autoimmune Diseases; Plaque psoriasis Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia Details
CNTO-6785 CNTO-6785; FTC-001 Phase 1 Clinical Morphosys Ag, Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Pulmonary Disease, Chronic Obstructive Details
JNJ-61178104 JNJ-61178104 Phase 1 Clinical Johnson & Johnson Innovative Medicine Autoimmune Diseases Details
Secukinumab biosimilar (BioRay Pharmaceutical) BR-201 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Autoimmune Diseases; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid Details
Secukinumab Biosimilar(Celltrion) CT-P55 Phase 1 Clinical Celltrion Inc Plaque psoriasis Details
Secukinumab biosimilar (CSPC Pharmaceutical Group) SYS6012; SYS-6012 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Plaque psoriasis Details
Secukinumab biosimilar (Gan & Lee) GLR1023; GLR-1023 Phase 1 Clinical Gan & Lee Pharmaceuticals Plaque psoriasis Details
anti-IL-17A humanized monoclonal antibody(Fontacea ) Phase 1 Clinical Shandong Fangtansi Biopharmaceutical Co Ltd Plaque psoriasis Details
CMAB-015 CMAB015; CMAB-015 Phase 1 Clinical Taizhou Mabtech Pharmaceutical Co Ltd Spondylitis, Ankylosing; Plaque psoriasis Details
DC-853 DC-853 Phase 1 Clinical Dice Therapeutics Inc Immune System Diseases Details
LEO-153339 LEO-153339 Phase 1 Clinical Leo Pharma Inc Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
ZL-1102 ZL-1102; CB-001 Phase 1 Clinical Crescendo Biologics Ltd, Zai Lab (Shanghai) Co Ltd Psoriasis Details
UCB-0159 UCB-0159 Phase 1 Clinical Ucb Sa Autoimmune Diseases Details
SSGJ-608 608; SSGJ-608 Phase 3 Clinical Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Spondylarthritis; Psoriasis; Plaque psoriasis Details
QX002N QX-002N Phase 3 Clinical Qyuns Therapeutics Co Ltd Spondylitis, Ankylosing; Asthma Details
Roconkibart JS005 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Gumokimab AK-111 Phase 3 Clinical Zhongshan Akeso Biopharma Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Skin Diseases; Psoriasis; Plaque psoriasis Details
Izokibep IMG-020; IMG020; ABY-035; AFB-035 Phase 3 Clinical Affibody Ab Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Secukinumab biosimilar (Bio-Thera Solutions) BAT-2306 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
CJM-112 CJM-112 Phase 2 Clinical Novartis Pharma Ag Acne Vulgaris; Triple Negative Breast Neoplasms; Multiple Sclerosis; Multiple Myeloma; Psoriasis; Asthma; Colorectal Neoplasms; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
SIM-0335 SIM-0335; SIM-335 Phase 2 Clinical BCY Pharm Co Ltd Plaque psoriasis Details
SCT-650C SCT650C; SCT-650-C; SCT-650C Phase 2 Clinical SinoCelltech Ltd Non-radiographic axial spondyloarthritis; Autoimmune Diseases; Plaque psoriasis Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia Details
CNTO-6785 CNTO-6785; FTC-001 Phase 1 Clinical Morphosys Ag, Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Pulmonary Disease, Chronic Obstructive Details
JNJ-61178104 JNJ-61178104 Phase 1 Clinical Johnson & Johnson Innovative Medicine Autoimmune Diseases Details
Secukinumab biosimilar (BioRay Pharmaceutical) BR-201 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Autoimmune Diseases; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Johnson & Johnson Innovative Medicine Arthritis, Rheumatoid Details
Secukinumab Biosimilar(Celltrion) CT-P55 Phase 1 Clinical Celltrion Inc Plaque psoriasis Details
Secukinumab biosimilar (CSPC Pharmaceutical Group) SYS6012; SYS-6012 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Plaque psoriasis Details
Secukinumab biosimilar (Gan & Lee) GLR1023; GLR-1023 Phase 1 Clinical Gan & Lee Pharmaceuticals Plaque psoriasis Details
anti-IL-17A humanized monoclonal antibody(Fontacea ) Phase 1 Clinical Shandong Fangtansi Biopharmaceutical Co Ltd Plaque psoriasis Details
CMAB-015 CMAB015; CMAB-015 Phase 1 Clinical Taizhou Mabtech Pharmaceutical Co Ltd Spondylitis, Ankylosing; Plaque psoriasis Details
DC-853 DC-853 Phase 1 Clinical Dice Therapeutics Inc Immune System Diseases Details
LEO-153339 LEO-153339 Phase 1 Clinical Leo Pharma Inc Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
ZL-1102 ZL-1102; CB-001 Phase 1 Clinical Crescendo Biologics Ltd, Zai Lab (Shanghai) Co Ltd Psoriasis Details
UCB-0159 UCB-0159 Phase 1 Clinical Ucb Sa Autoimmune Diseases Details

This web search service is supported by Google Inc.

totop

Laisser un message