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Découvrez notre série de protéines de haute qualité couvrant des indicateurs diagnostiques complets afin de faciliter la recherche diagnostique in vitro des maladies neurologiques.
Les fibrilles préformées constituent un modèle préclinique inestimable pour explorer la pathogenèse des maladies neurologiques par l'agrégation de protéines mal repliées. Découvrez nos PFF pré-ensemencées à utiliser dans le cadre de vos recherches.
Les facteurs neuronaux sont une classe de molécules protéiques dotées d'une activité neurotrophique qui peut favoriser la survie et la régénération des cellules nerveuses. Découvrez notre série de facteurs neuronaux recombinants destinés à favoriser la culture et la différenciation des cellules nerveuses.
En partenariat avec Diagnostic Biochips, nous proposons désormais des solutions pour les enregistrements électrophysiologiques in vivo, notamment des électrodes multicanaux de haute qualité et d'autres produits destinés à faciliter l'analyse efficace et de haute qualité de la structure et de la fonction des circuits neuronaux.
Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Covering iPSC neural cells, brain organoids, and microelectrode array services, our tools support neural development, disease modeling, and drug screening with high quality and reliable performance to meet diverse research needs.
Les marqueurs protéiques sont un élément essentiel de la recherche biologique et du développement de médicaments. Que ce soit pour l'électrophorèse des protéines ou le western blot, nos marqueurs protéiques pré-colorés vous aident à déterminer rapidement le poids moléculaire de la protéine cible ou à évaluer l'efficacité du transfert.
La streptavidine est une protéine tétramérique offrant 4 sites de liaison à la biotine de haute affinité. Nous proposons une large gamme de produits préconjugués à la streptavidine pour soutenir votre recherche ainsi que des protéines biotinylées.
L'utilisation de l'anticorps de contrôle isotype correspondant pour détecter la liaison non spécifique permet de réduire la production de résultats faussement positifs et d'évaluer avec précision les facteurs d'influence possibles au cours du processus de développement du médicament. Découvrez nos contrôles d'isotypes pour votre recherche.
Vous souhaitez développer votre propre test de chimiluminescence ? Explorez nos produits pour assembler votre propre MPCLIA en fonction de vos besoins !
L'efficacité d'un anticorps thérapeutique dépend du fragment Fab et de son activité de liaison à l'antigène cible, mais aussi du fragment Fc et de son interaction avec les principaux récepteurs Fc. Par conséquent, les candidats doivent être testés sur un ensemble de récepteurs durant l’ingénierie de l’anticorps. Explorez notre collection complète de protéines recombinantes du récepteur Fc !
Nous nous sommes engagés à accélérer la recherche, le développement, l'approbation et la commercialisation de vaccins contre les maladies infectieuses. Avec cette idée, ViruStop est spécialement conçu pour la recherche sur les virus !
Des anticorps spécifiques à l'antigène ou neutralisants sont disponibles pour votre recherche ! Que vous cherchiez à réaliser des tests de neutralisation ou à évaluer les titres d'anticorps, explorez notre catalogue d'anticorps !
Au lieu de développer vos propres tests, découvrez nos kits et tests conçus pour quantifier rapidement la présence d'antigènes ou le titre d'anticorps !
Fig 1. Schematic
diagram of IL-4/IL-4R signaling pathway.
Interleukin-4Rα (IL-4Rα), the key receptor of IL-4, has
emerged as an ‘inspiring’ target for innovative therapies aimed at treating various inflammatory and
oncological diseases. IL-4Rα is a type I transmembrane protein that plays a key role in the molecular
pathway that drives a specific immune pattern called type II inflammations.
This pathway is driven
by two cytokines: interleukin-4 (IL-4) and interleukin-13 (IL-13). Both cytokines have diverse biological and
immunological effects on lymphocytes, dendritic cells and fibroblasts adjustment function. Specifically,
these cytokines bind to IL-4Rα to initiate the type II inflammation pathway that includes differentiation of
Th2 cells, airway inflammation and mucus production.
Clinical Application
IL-4R and cytokines IL-4 and IL-13 are key regulators in humoral and adaptive immunity.
This means that an imbalance in either receptor expression or circulating signaling cytokines can be clinically
observed. The resultant immune overreaction is initiated by an initial imbalance of TH1 and TH2 differentiation
that drives an abnormal secretion of cytokines. Activated Th2 cells release cytokines including IL-4, 13, and
31, which activate downstream B cells to transform and produce immunoglobulin E (IgE) antibodies. In turn, mast
cells and basophils are recruited to degranulate and produce inflammatory factors. Simultaneously, the secreted
IL-4 and 13 continue to bind to its respective receptors (e. g. IL-4R) that repeatedly promotes TH2
differentiation and subsequent inflammation. This effect is observed through several autoimmune diseases
including asthma, eczema, and hay fever, as well as in metastatic tumors.
Asthma
Asthma is a complex, persistent, and lifelong inflammatory disease. Dupilumab
is a human monoclonal antibody targeting IL-4Rα. Its mechanism of action is to specifically block the
type II IL-4R/IL-13R signaling pathway while inhibiting the intracellular activity of IL-4 and IL-13
with STAT6. By preventing cytokine signaling at the source, the Th2 inflammatory response is minimized.
Eczema
Eczema, otherwise known as atopic dermatitis, is a disease characterized by
skin inflammation, dry skin, rashes, and blisters. Recent studies have begun to emphasize that eczema
may stem from overexpression of IL-13/IL-4 signaling in specific individuals. Thus, development of
therapies targeting the IL-13/IL-4 /IL-4R and its intracellular signaling pathway is a promising
innovative strategy.
Hay Fever
Hay fever, also known as allergic rhinitis, is a common chronic disease that
is driven by an IgE mediated inflammatory response in the nasal mucosa and cause a variety of
complications. In a recent study, inhibition of the IL-4/STAT6/GATA3 signaling pathway can reduce IL-4
secretion, serum IgE and airway mucus production, effectively improving symptoms due to hay fever.
Metastatic Tumors
Beyond autoimmune diseases, IL-4R is also overexpressed in many epithelial
cancers. Whereas the intracellular signaling of IL-4/ IL-4R in lymphocytes drives the type II
inflammation pathway. As such, overexpression of IL-4R drives metastasis and tumor growth, revealing
IL-4R inhibitory drugs as a potential therapeutic tool for metastatic tumors.
Product Features
Native conformation, free protocol
shared
High biological activity verified by
ELISA/SPR/ BLI
Authentic structure verified by
SEC-MALS
Comprehensive products with various
tags and species
HumanI IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253）on
SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of
the protein is greater than 95%
High structural homogeneity (>90%) verified by SEC-MALS
The purity of Cynomolgus IL-4, Fc Tag (Cat. No. IL4-C5259) is more than90%and the molecular weight of this protein is around85-115 kDaverified by SEC-MALS.
High biological activity verified by ELISA
Immobilized ActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218)at 5 μL/mL (100 μL/well) can
bind Biotinylated Human IL-4 R alpha, Avitag,His Tag (Cat. No.
ILR-H82E9) with a linear range of 2-78 ng/mL.
Immobilized ActiveMax® Human IL-4, Tag Free(Cat. No. IL4-H4218)at 5 μg/mL (100 μL/well) can
bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a
linear range of 1-20 ng/mL.
Affinity verified by SPR and BLI
Biotinylated Human IL-13 R alpha 1 Protein, His,Avitag (Cat. No. IL1-H82E8)
captured on Biotin CAP-Series S Sensor Chip can bind Human IL-13, His Tag (Cat. No.IL3-H52H4) with an affinity constant of 34.4 nM as
determined in a SPR assay (Biacore 8K)
Loaded Biotinylated Human IL-13, His,Avitag (Cat. No. IL3-H82E5) on SA Biosensor,
can bind Human IL-13 R alpha 2, His Tag (Cat. No.IL2-H52H5) with an
affinity constant of 6.31 nM as determined in BLI assay (ForteBio Octet Red96e).
[1] Weng, S. Y., Wang, X., Vijayan, S., Tang, Y., Kim, Y. O., Padberg, K., ... & Schuppan, D. (2018). IL-4
receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and
reversal. EBioMedicine, 29, 92-103.https://doi.org/10.1016/j.ebiom.2018.01.028.
[2] Husna, S. M. N., Shukri, N. M., Ashari, N. S. M., & Wong, K. K. (2022). IL-4/IL-13 axis as therapeutic
targets in allergic rhinitis and asthma. PeerJ, https://doi.org/10, e13444.10.7717/peerj.13444.
[3] Liang, K. L., Yu, S. J., Huang, W. C., & Yen, H. R. (2020). Luteolin attenuates allergic nasal
inflammation via inhibition of interleukin-4 in an allergic rhinitis mouse model and peripheral blood from
human subjects with allergic rhinitis. Frontiers in pharmacology, 11,
291.https://doi.org/10.3389/fphar.2020.00291.
[4] Bankaitis, K. V., & Fingleton, B. (2015). Targeting IL4/IL4R for the treatment of epithelial cancer
metastasis. Clinical & experimental metastasis, 32(8), 847-856.https://doi.org/10.1007/s10585-015-9747-9.
[5] Moran, A., & Pavord, I. D. (2020). Anti-IL-4/IL-13 for the treatment of asthma: The story so far.
Expert Opinion on Biological Therapy, 20(3), 283-294.
https://doi.org/10.1080/14712598.2020.1714027.
[6] Furue, M. (2020). Regulation of skin barrier function via competition between AHR axis versus
IL-13/IL-4‒JAK‒STAT6/STAT3 axis: pathogenic and therapeutic implications in atopic dermatitis. Journal of
Clinical Medicine, 9(11), 3741.https://doi.org/10.3390/jcm9113741.
[7] Pelaia, C., Pelaia, G., Crimi, C., Maglio, A., Armentaro, G., Calabrese, C., ... & Vatrella, A.
(2022). Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and
13. Vaccines, 10(6), 974.https://doi.org/10.3390/vaccines10060974.
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Limited Edition Golden Llama is here! Check out how you can get one. 
Limited Edition Golden Llama is here! Check out how you can get one. 
A-Z
Native conformation, free protocol
shared
