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Mesothelin

Brief Information

Name:Mesothelin
Target Synonym:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:41
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CEA-B030 Human ClinMax™ Human Soluble Mesothelin ELISA Kit, PRO
SCCHO-ATP120 Human CHO/Human Mesothelin Stable Cell Line
CHEK-ATP119 Human HEK293/Human Mesothelin Stable Cell Line
MBS-C003 Human ActiveMax® Human MSLN μBeads, premium grade (for cells)
MSN-M5254 Mouse Mouse Mesothelin / MSLN Protein, Fc Tag
MSN-M5254-structure
MSN-M5254-sds
MSN-H5267 Human Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
MSN-H5267-structure
MSN-H5267-sds
MSN-HA2H9 Human Alexa Fluor™ 488-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H9-structure
MSN-HA2H5 Human Alexa Fluor™ 647-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H5-structure
MSN-HA2H8 Human Alexa Fluor™ 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H8-structure
MSN-HA2H7 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H7-structure
MSN-HA2H6 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6-structure
MSN-HP2H8 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8-structure
MSN-HF2H3 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HF2H3-structure
MSN-HF2H3-sds
MSN-H82E7 Human Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-H82E7-structure
MSN-H82E7-sds
MSN-R52H4 Rat Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-R52H4-structure
MSN-R52H4-sds
MBS-K024 Human Human Mesothelin-coupled Magnetic Beads
MSN-M82E7 Mouse Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MSN-M82E7-structure
MSN-M82E7-sds
MSN-HP2H5 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-C52H6 Cynomolgus Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-C52H6-structure
MSN-C52H6-sds
MSN-M52H3 Mouse Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M52H3-structure
MSN-M52H3-sds
MSN-HF25x Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x-structure
MSN-HF25x-sds
MSN-HR2P4 Human RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4-structure
MSN-HR2P4-sds
MSN-HG2P4 Human GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4-structure
MSN-HG2P4-sds
MSN-HF223 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF223-structure
MSN-HF223-sds
MSN-HF253 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF253-structure
MSN-HF253-sds
MSN-H82F6 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™, premium grade
MSN-H82F6-structure
MSN-H82F6-sds
MSN-H522a Human Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
MSN-H522a-structure
MSN-H522a-sds
MSN-H5253 Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
MSN-H5253-structure
MSN-H5253-sds
MSN-H82E9 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
MSN-H82E9-structure
MSN-H82E9-sds
MSN-H826x Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H826x-structure
MSN-H826x-sds
MSN-H8223 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H8223-structure
MSN-H8223-sds
MSN-H526x Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H526x-structure
MSN-H526x-sds
MSN-H5222 Human Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5222-structure
MSN-H5222-sds
ACRO Quality

Part of Bioactivity data

MSN-HP2H8-Cell-based assay
Evaluation of CAR expression

5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Mesothelin (296-580), His Tag Star staining (Cat. No. MSN-HP2H8) and negative control protein respectively(Fig. C and B), and non- transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity (QC tested).

MSN-HR2P4-SPR
 Mesothelin SPR

Anti-human MSLN mAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind RFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HR2P4) with an affinity constant of 0.304 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

MSN-HG2P4-SPR
 Mesothelin SPR

Anti-human MSLN MAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind GFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HG2P4) with an affinity constant of 0.542 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Customer Reviews

Synonym Name

MSLN,Mesothelin,MPF

Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Clinical and Translational Updates

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