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Your Position: Accueil > IL-15 R alpha

IL-15 R alpha

Brief Information

Name:Interleukin-15 receptor subunit alpha
Target Synonym:Interleukin 15 Receptor Alpha Isoform IC2,Interleukin 15 Receptor Alpha Isoform IC8,Interleukin 15 Receptor Alpha Isoform EM2,Interleukin-15 Receptor Subunit Alpha,Interleukin 15 Receptor Alpha Isoform IC4,Interleukin 15 Receptor Alpha Isoform IC5,Interleukin 15 Receptor Alpha Isoform IC7,IL15RA,CD215,IL-15RA,IL-15 Receptor Subunit Alpha,CD215 Antigen,Interleukin 15 Receptor Subunit Alpha,Interleukin 15 Receptor Alpha Isoform IC6,Interleukin 15 Receptor, Alpha,Interleukin 15 Receptor Alpha Isofo
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Phase 3 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
ILA-H82E5 Human Biotinylated Human IL-15 R alpha Protein, His,Avitag™ (MALS verified)
ILA-H82E5-structure
ILA-H82E5-sds
ILA-HP2F6 Human PE-Labeled Human IL-15 R alpha / CD215 Protein, Fc Tag (Site-specific conjugation)
ILA-HP2F6-structure
ILA-HF255 Human FITC-Labeled Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified)
ILA-HF255-structure
ILA-HF255-sds
ILA-M5253 Mouse Mouse IL-15 R alpha / CD215 Protein, Fc Tag
ILA-M5253-structure
ILA-M5253-sds
ILA-H82F4 Human Biotinylated Human IL-15 R alpha / CD215 Protein, Fc,Avitag™ (MALS verified)
ILA-H82F4-structure
ILA-H82F4-sds
ILA-H5253 Human Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified)
ILA-H5253-structure
ILA-H5253-sds
ACRO Quality

Part of Bioactivity data

ILA-H5253-Cell-based assay
IL-15 R alpha CELL

Human IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) inhibits IL-15-dependent proliferation of CTLL-2 cells. The ED50 for this effect is 2.77-4.20 ng/mL (Routinely tested).

Protocol
ILA-HF255-ELISA
IL-15 R alpha ELISA

Immobilized Human IL-15, His Tag (Cat. No. IL5-H52H8) at 2 μg/mL (100 μL/well) can bind FITC-Labeled Human IL-15 R alpha, Fc Tag (Cat. No. ILA-HF255) with a linear range of 0.078-5 μg/mL (QC tested).

Protocol
ILA-H82E5-MALS-HPLC
IL-15 R alpha MALS images

The purity of Biotinylated Human IL-15 R alpha Protein, His,Avitag (Cat. No. ILA-H82E5) is more than 90% and the molecular weight of this protein is around 40-50 kDa verified by SEC-MALS.

Synonym Name

IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha

Background

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NKTR-255 NKTR-255 Phase 3 Clinical Nektar Therapeutics Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Large B-Cell, Diffuse; Small Cell Lung Carcinoma; Multiple Myeloma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Lung Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
SHR-1501 SHR-1501 Phase 2 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms; Urinary Bladder Neoplasms Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 Phase 1 Clinical Genentech Inc, Xencor Inc Solid tumours; Neoplasms; Multiple Myeloma Details
BJ-001(Boji Biomedical Technology) BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Communicable Diseases; Neoplasm Metastasis Details
ASKG-915 ASKG-915 Phase 1 Clinical Askgene Pharma Solid tumours; Neoplasms Details
ASKG-315 ASKG-315; ASKG-215b; ASKG-215β Phase 1 Clinical Askgene Pharma Solid tumours; Neoplasms Details
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
VG-203 VG-203; VG2062; VG-2062 Phase 1 Clinical ViroGin Biotech Ltd, Shanghai Funuojian Biotechnology Co Ltd, Virogin Biotech (Shenzhen) Ltd, Fenojian Biotechnology (Nantong) Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Breast Neoplasms Details
FL115 FL115; FL-115 Phase 1 Clinical Suzhou Forlongbiotech Co Ltd Solid tumours; Urinary Bladder Neoplasms Details
QL-415 QL-415 Phase 1 Clinical Qlsf Biotherapeutics Inc Neoplasms Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details
PF-07209960 PF-07209960 Phase 1 Clinical Pfizer Inc Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
NKTR-255 NKTR-255 Phase 3 Clinical Nektar Therapeutics Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Carcinoma, Transitional Cell; Lymphoma, Large B-Cell, Diffuse; Small Cell Lung Carcinoma; Multiple Myeloma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Lung Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
SHR-1501 SHR-1501 Phase 2 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms; Urinary Bladder Neoplasms Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 Phase 1 Clinical Genentech Inc, Xencor Inc Solid tumours; Neoplasms; Multiple Myeloma Details
BJ-001(Boji Biomedical Technology) BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Communicable Diseases; Neoplasm Metastasis Details
ASKG-915 ASKG-915 Phase 1 Clinical Askgene Pharma Solid tumours; Neoplasms Details
ASKG-315 ASKG-315; ASKG-215b; ASKG-215β Phase 1 Clinical Askgene Pharma Solid tumours; Neoplasms Details
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
VG-203 VG-203; VG2062; VG-2062 Phase 1 Clinical ViroGin Biotech Ltd, Shanghai Funuojian Biotechnology Co Ltd, Virogin Biotech (Shenzhen) Ltd, Fenojian Biotechnology (Nantong) Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Breast Neoplasms Details
FL115 FL115; FL-115 Phase 1 Clinical Suzhou Forlongbiotech Co Ltd Solid tumours; Urinary Bladder Neoplasms Details
QL-415 QL-415 Phase 1 Clinical Qlsf Biotherapeutics Inc Neoplasms Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details
PF-07209960 PF-07209960 Phase 1 Clinical Pfizer Inc Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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