Acrobiosystems for English
icon_bulk_orderAchat groupé/Commande rapide
user
  1. Tableau de bord
  2. Mon profil
  3. Mon adresse
  4. Mes commandes
  5. Adhésion à Acro
Connexion Inscription
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP IL-2 Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
Il n'y a pas de produit dans le panier !
Mon panier|Check Out
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Accueil > CD28

CD28

Brief Information

Name:T-cell-specific surface glycoprotein CD28
Target Synonym:CD28,CD28 Antigen,T-Cell-Specific Surface Glycoprotein CD28,CD28 Antigen (Tp44),Tp44,CD28 Antigens,CD28 Molecule,T-Cell-Specific Surface Glycoprotein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:25
Lastest Research Phase:Phase 3 Clinical

Product ListCompare or Buy

Product> Filter Results
Par statut du produit :
Par catégorie de produit :
Par espèce :
Par étiquette :
Par conjugaison :
Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CD8-AHFC1 Mouse APC-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (0.03% Proclin)
CD8-PCFC1 Mouse PE-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (0.03% Proclin)
CD8-H52H3 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag, active dimer (MALS verified)
CD8-H52H3-structure
CD8-H52H3-sds
CRS-A014 Mouse resDetect™ Anti-CD28 Antibody ELISA Kit
CD8-R52H9 Rat Rat CD28 Protein, His Tag (BLI verified)
CD8-R52H9-structure
CD8-R52H9-sds
CD8-M5258 Mouse Mouse CD28 Protein, Fc Tag (MALS verified)
CD8-M5258-structure
CD8-M5258-sds
CD8-M82E3 Mouse Biotinylated Mouse CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-M82E3-structure
CD8-M82E3-sds
CD8-H82E5 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, His,Avitag™, active dimer (MALS verified)
CD8-H82E5-structure
CD8-H82E5-sds
CD8-H525a Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc Tag, active dimer (MALS verified)
CD8-H525a-structure
CD8-H525a-sds
CD8-H52A5 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag (MALS verified)
CD8-H52A5-structure
CD8-H52A5-sds
CD8-H82F2 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc,Avitag™, active dimer (MALS verified)
CD8-H82F2-structure
CD8-H82F2-sds
CD8-M52H6 Mouse Mouse CD28 Protein, His Tag, active dimer (MALS verified)
CD8-M52H6-structure
CD8-M52H6-sds
ACRO Quality

Part of Bioactivity data

CD8-AHFC1-Cell-based assay
CD28 FACS

Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with APC-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (Cat. No. CD8-AHFC1) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. APC signal was used to evaluate the binding activity (QC tested).

Protocol
CD8-AHFC1-Cell-based assay
CD28 FACS

Non-specificity of APC-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (Cat. No. CD8-AHFC1) binding to CD3- cells present in human PBMC. Human PBMCs were simultaneously stained with FITC anti-human CD3 Antibody and APC-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (2 μL of the antibody stock solution corresponds to labeling of 5e5 cells in a final volume of 100 µL), washed and then analyzed with FACS. FITC negative signals and APC positive signals were used to evaluate the non-specific binding activity to human CD3- cells (Routinely tested).

Protocol
CD8-H525a-SPR
CD28 SPR

Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, His Tag (Cat. No. B71-H5228) with an affinity constant of 5.29 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
CD8-H525a-SPR
CD28 SPR

Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. B71-H52A4) with an affinity constant of 2.72 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CD28,Tp44

Background

T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

Clinical and Translational Updates

Related Molecule

B7-1 B7-2

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Reltecimod P2-TA; AB-103 Phase 3 Clinical Atox Bio Ltd Peritonitis; Acute Kidney Injury; Fasciitis, Necrotizing; Fournier Gangrene; Soft Tissue Infections Details
Nezastomig REGN-5678 Phase 2 Clinical Carcinoma, Renal Cell; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
Abatacept (Orban Biotech) Phase 2 Clinical Orban Biotech, The National Institute Of Diabetes And Digestive And Kidney Diseases Diabetes Mellitus, Type 1 Details
Lulizumab pegol Lulizumab; BMS-931699 Phase 2 Clinical Bristol-Myers Squibb Company Lupus Vulgaris; Rejection of renal transplantation; Sjogren-Larsson Syndrome Details
Acazicolcept ALPN-101 Phase 2 Clinical Alpine Immune Sciences Inc Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation Details
FR-104 FR-104; JNJ-3133; VEL-101 Phase 2 Clinical Effimune Rejection of renal transplantation; Arthritis, Rheumatoid; Postoperative Complications Details
TC-510 TC-510 Phase 2 Clinical Tcr2 Therapeutics Inc Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Mesothelioma; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
REGN-7075 REGN-7075 Phase 2 Clinical Solid tumours Details
REGN-5668 REGN-5668 Phase 2 Clinical Ovarian Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms Details
ATLCAR.k.CD28 cells (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma Details
SAR-442257 SAR-442257 Phase 1 Clinical Sanofi Neoplasms Details
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) Phase 1 Clinical City Of Hope National Medical Center Lymphoma, Non-Hodgkin Details
JNJ-1493 JNJ-1493 Phase 1 Clinical Xencor Inc Hematologic Neoplasms; Lymphoma, B-Cell Details
JNJ-9401 JNJ-9401 Phase 1 Clinical Xencor Inc Prostatic Neoplasms Details
JNJ-87189401 JNJ-87189401 Phase 1 Clinical Janssen Research & Development Llc Prostatic Neoplasms Details
REGN5837 REGN5837; REGN-5837 Phase 1 Clinical Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
CC-312 CC-312 Phase 1 Clinical CytoCares (Shanghai) Inc Hematologic Neoplasms; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
RG-6333 RO-7443904 Phase 1 Clinical F. Hoffmann-La Roche Ag Lymphoma, Non-Hodgkin Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
SAR-443216 SAR-443216 Phase 1 Clinical Sanofi Solid tumours; Stomach Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms Details
CD19 PD-1/CD28 CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine) Phase 1 Clinical Second Affiliated Hospital Of Zhejiang University School Of Medicine Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Primary mediastinal B cell lymphoma Details
FPT-155 CD80-Fc; FPT-155 Phase 1 Clinical Five Prime Therapeutics Inc Solid tumours Details
Theralizumab TAB-08; TABO-8 Phase 1 Clinical Theramab Llc Solid tumours; Carcinoma, Merkel Cell; Arthritis, Rheumatoid; Psoriasis; Lupus Erythematosus, Systemic Details
B7-2/GM-CSF cancer gene therapy CIT Phase 1 Clinical Radient Neoplasms Details
InHeAb-01 InHeAb-01; bsAB Clinical University Hospital Tuebingen Neoplasms Details
Reltecimod P2-TA; AB-103 Phase 3 Clinical Atox Bio Ltd Peritonitis; Acute Kidney Injury; Fasciitis, Necrotizing; Fournier Gangrene; Soft Tissue Infections Details
Nezastomig REGN-5678 Phase 2 Clinical Carcinoma, Renal Cell; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
Abatacept (Orban Biotech) Phase 2 Clinical Orban Biotech, The National Institute Of Diabetes And Digestive And Kidney Diseases Diabetes Mellitus, Type 1 Details
Lulizumab pegol Lulizumab; BMS-931699 Phase 2 Clinical Bristol-Myers Squibb Company Lupus Vulgaris; Rejection of renal transplantation; Sjogren-Larsson Syndrome Details
Acazicolcept ALPN-101 Phase 2 Clinical Alpine Immune Sciences Inc Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation Details
FR-104 FR-104; JNJ-3133; VEL-101 Phase 2 Clinical Effimune Rejection of renal transplantation; Arthritis, Rheumatoid; Postoperative Complications Details
TC-510 TC-510 Phase 2 Clinical Tcr2 Therapeutics Inc Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Mesothelioma; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
REGN-7075 REGN-7075 Phase 2 Clinical Solid tumours Details
REGN-5668 REGN-5668 Phase 2 Clinical Ovarian Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms Details
ATLCAR.k.CD28 cells (UNC Lineberger Comprehensive Cancer Center) Phase 1 Clinical Unc Lineberger Comprehensive Cancer Center Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma Details
SAR-442257 SAR-442257 Phase 1 Clinical Sanofi Neoplasms Details
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) Phase 1 Clinical City Of Hope National Medical Center Lymphoma, Non-Hodgkin Details
JNJ-1493 JNJ-1493 Phase 1 Clinical Xencor Inc Hematologic Neoplasms; Lymphoma, B-Cell Details
JNJ-9401 JNJ-9401 Phase 1 Clinical Xencor Inc Prostatic Neoplasms Details
JNJ-87189401 JNJ-87189401 Phase 1 Clinical Janssen Research & Development Llc Prostatic Neoplasms Details
REGN5837 REGN5837; REGN-5837 Phase 1 Clinical Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
CC-312 CC-312 Phase 1 Clinical CytoCares (Shanghai) Inc Hematologic Neoplasms; Lymphoma, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
RG-6333 RO-7443904 Phase 1 Clinical F. Hoffmann-La Roche Ag Lymphoma, Non-Hodgkin Details
XmAb-808 XmAb808 Phase 1 Clinical Xencor Inc Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
SAR-443216 SAR-443216 Phase 1 Clinical Sanofi Solid tumours; Stomach Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms Details
CD19 PD-1/CD28 CAR-T Cell Therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine) Phase 1 Clinical Second Affiliated Hospital Of Zhejiang University School Of Medicine Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Primary mediastinal B cell lymphoma Details
FPT-155 CD80-Fc; FPT-155 Phase 1 Clinical Five Prime Therapeutics Inc Solid tumours Details
Theralizumab TAB-08; TABO-8 Phase 1 Clinical Theramab Llc Solid tumours; Carcinoma, Merkel Cell; Arthritis, Rheumatoid; Psoriasis; Lupus Erythematosus, Systemic Details
B7-2/GM-CSF cancer gene therapy CIT Phase 1 Clinical Radient Neoplasms Details
InHeAb-01 InHeAb-01; bsAB Clinical University Hospital Tuebingen Neoplasms Details

This web search service is supported by Google Inc.

totop
Call us
Call us

Germany+49 800 0826645

United Kingdom+44 808 281 3436

Netherlands+31 800 0224992

Switzerland+41 800 040 012

France+33 800 90 78 85

Sweden+46 20 12 76 94

Denmark+45 80 83 07 62

Belgium+32 800 27 125

Email
E-Mail
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
Lichtstrasse 35,4056 Basel, Switzerland
linkedin twitter facebook youtube

Laisser un message

Copyright © 2017 ACROBiosystems. All Rights Reserved
Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap