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A-Z
> Solid Tumor CAR Targets
Nature reviews. Drug discovery vol. 20,7 (2021): 531-550.
More than 30 + solid tumor targets
Various species including human, mouse, monkey, rabbit, etc
High bioactivity verified by FACS/ELISA/SPR
Alexa Fluor 488/555/647, PE, APC, FITC-labels available
Some products have been filed with FDA DMF to support your IND, NDA and BLA
> Mesothelin，MSLN
> Highly expressed in mesothelial tumors, ovarian cancer and pancreatic cancer
> Mesothelin abnormal expression by activating P13K, ERK and MAPK signaling pathways cause cancer cell proliferation, invasion and metastasis.
> Glypican 3，GPC3
> Associated with hepatocellular carcinoma, ovarian carcinoma, and squamous cell carcinoma
> Interacts with various growth factors and signaling molecules in the tumor microenvironment that affect tumor cell proliferation, migration, invasion and development process.
> Human epidermal growth factor receptor 2，HER2
> Related to breast cancer, gastric cancer, lung cancer and non-small cell lung cancer
> Promotes cell division and the secretion of proteolytic enzymes, thereby promoting tumor invasion and metastasis.
> Fibroblast activation protein，FAP
> Selectively high expression on the surface of cancer associated fibroblasts (CAF)
> Degrades tumor stroma and promote cancer cell invasion and metastasis in a variety of tumors.
The purity of Human Mesothelin (296-580), His Tag, low endotoxin (Cat. No. MSN-H522a) is more than 90% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.
Immobilized Monoclonal Anti-Human GPC3 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human Glypican 3, His, Avitag (Cat. No. GP3-H82E5) with a linear range of 0.2-3 ng/mL (QC tested).
Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab with a linear range of 0.2-3 ng/mL (Routinely tested).
5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF488-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HA2H9) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF488 signal was used to evaluate the binding activity (QC tested).
5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).
5e5 of anti-GPC3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Glypican 3, His Tag (Cat. No. GP3-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
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